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The Effect of ONO-2506 on Permanent Focal Ischemia in Rats

  • Conference paper
Book cover Maturation Phenomenon in Cerebral Ischemia III

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Abstract

A novel synthetic agent, ONO-2506, which inhibits the production of S-100 protein by cultured astrocytes, was shown to ameliorate the brain damage following transient focat ischemia in rats. In the present study, we aimed to further examine its effects in the permanent middle cerebral artery occlusion (MCAO) model in rats.

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Authors
  1. T. Asano
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  2. T. Matsui
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  3. E. Mori
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  4. A. Tamura
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  5. N. Tateishi
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  6. Y. Kagamiishi
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  7. S. Satoh
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  8. K. Kondo
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shi, Tokyo 180, Japan

    Umeo Ito

  2. Dipartimenti di Scienze Neurologiche, Università di Roma “La Sapienza”, Viale dell’University 30, 00185, Roma, Italy

    Cesare Fieschi

  3. Istituto Neurologico Mediterraneo, NEUROMED Research Laboratories, Via Atinense 18, 86077, Pozzilli (Isernia), Italy

    Francesco Orzi

  4. Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113 Tokyo, Japan

    Toshihiko Kuroiwa

  5. National Institutes of Health, Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, Bethesda, MD, 20892-4128, USA

    Igor Klatzo

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© 1999 Springer-Verlag Berlin Heidelberg

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Asano, T. et al. (1999). The Effect of ONO-2506 on Permanent Focal Ischemia in Rats. In: Ito, U., Fieschi, C., Orzi, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58602-6_38

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  • DOI: https://doi.org/10.1007/978-3-642-58602-6_38

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65023-2

  • Online ISBN: 978-3-642-58602-6

  • eBook Packages: Springer Book Archive

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