Abstract
Accumulating evidence indicates that overexpression of S-100 protein, an astrocyte-derived protein, is detrimental to neuronal cells, resulting in various pathological conditions. Since ONO-2506 was shown to have a modulating action on the increase of S-100β content in cultured astrocytes, its time-dependent effects on the neurological deficits, brain water content, infarct volume, immunoreactivities of S-100 protein, and expression of inducible NO synthase messenger ribonucleic acid (iNOS mRNA) following transient focal ischemia in rats, were examined. We report here that ONO-2506 significantly ameliorates brain damage following transient focal ischemia, presumably through its inhibitory action on the overexpression of S-100 protein and iNOS mRNA.
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© 1999 Springer-Verlag Berlin Heidelberg
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Tateishi, N., Kagamiishi, Y., Shimoda, T., Shintaku, K., Satoh, S., Kondo, K. (1999). Amelioration of Brain Damage Following Transient Focal Ischemia in Rats by ONO-2506: Relevance of Its Modulating Action on Astroglial Functions. In: Ito, U., Fieschi, C., Orzi, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58602-6_37
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DOI: https://doi.org/10.1007/978-3-642-58602-6_37
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-65023-2
Online ISBN: 978-3-642-58602-6
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