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The Protective Effect of DY9760e, a Novel Calmodulin Antagonist, on Rat Permanent Middle Cerebral Artery Occlusion

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Book cover Maturation Phenomenon in Cerebral Ischemia III

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Abstract

A newly synthesized calmodulin antagonist, DY9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1(-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate), has been shown to possess a cytoprotective effect against cytotoxicity induced by Ca2+ overload [1]. Since Ca2+ overload is suspected to be one of the major causes of ischemic neuronal cell damage [2], we examined the effect of this drug on infarct volume in the rat permanent focal ischemia model.

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References

  1. Sugimura M, Sato T, Nakayama W, Morishima Y, Fukunaga K, Omitsu M, Miyamoto E, Shirasaki Y (1997) DY-9760e, a novel calmodulin antagonist with cytoprotective action. Eur J Pharmacol 336: 99–106

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  2. Siesjö BK, Bengtsson F (1989) Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis. J Cereb Blood Flow Metab 9: 127–190

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Authors
  1. K. Takagi
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  2. A. Tamura
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  3. H. Nakayama
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  4. K. Narita
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  5. M. Aoki
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  6. T. Sato
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  7. Y. Shirasaki
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shi, Tokyo 180, Japan

    Umeo Ito

  2. Dipartimenti di Scienze Neurologiche, Università di Roma “La Sapienza”, Viale dell’University 30, 00185, Roma, Italy

    Cesare Fieschi

  3. Istituto Neurologico Mediterraneo, NEUROMED Research Laboratories, Via Atinense 18, 86077, Pozzilli (Isernia), Italy

    Francesco Orzi

  4. Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113 Tokyo, Japan

    Toshihiko Kuroiwa

  5. National Institutes of Health, Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, Bethesda, MD, 20892-4128, USA

    Igor Klatzo

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© 1999 Springer-Verlag Berlin Heidelberg

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Takagi, K. et al. (1999). The Protective Effect of DY9760e, a Novel Calmodulin Antagonist, on Rat Permanent Middle Cerebral Artery Occlusion. In: Ito, U., Fieschi, C., Orzi, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58602-6_36

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  • DOI: https://doi.org/10.1007/978-3-642-58602-6_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65023-2

  • Online ISBN: 978-3-642-58602-6

  • eBook Packages: Springer Book Archive

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