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Environmental Influence on Neurotrophic Gene Expression After Experimental Brain Infarction in the Rat

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Maturation Phenomenon in Cerebral Ischemia III

Summary

We have investigated whether post-ischemic housing in an activity-stimulating environment stimulates gene expression for brain-derived neurotrophic factor (BDNF), a neurotrophic factor known to stimulate brain plasticity in intact animals, in focal brain ischemia. From 30 h after a middle-cerebral-artery ligation, rats were housed in standard cages or in larger cages, allowing various activities. In situ hybridization was performed on brain from rats killed 2, 3, 7 and 12 days after the arterial ligation. Contrary to our hypothesis, rats in an enriched environment had significantly lower BDNF messenger RNA (mRNA) than rats in standard environment in the pert-infarct area, cortex contralateral to infarction and hippocampus. Determination of whether or not the lower BDNF mRNA levels in activity-stimulated rats corresponds to lower synthesis of BDNF is needed to evaluate the functional significance of the data.

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Authors
  1. B. B. Johansson
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  2. L.-R. Zhao
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  3. B. Mattsson
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shi, Tokyo 180, Japan

    Umeo Ito

  2. Dipartimenti di Scienze Neurologiche, Università di Roma “La Sapienza”, Viale dell’University 30, 00185, Roma, Italy

    Cesare Fieschi

  3. Istituto Neurologico Mediterraneo, NEUROMED Research Laboratories, Via Atinense 18, 86077, Pozzilli (Isernia), Italy

    Francesco Orzi

  4. Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113 Tokyo, Japan

    Toshihiko Kuroiwa

  5. National Institutes of Health, Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, Bethesda, MD, 20892-4128, USA

    Igor Klatzo

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© 1999 Springer-Verlag Berlin Heidelberg

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Johansson, B.B., Zhao, LR., Mattsson, B. (1999). Environmental Influence on Neurotrophic Gene Expression After Experimental Brain Infarction in the Rat. In: Ito, U., Fieschi, C., Orzi, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58602-6_31

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  • DOI: https://doi.org/10.1007/978-3-642-58602-6_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65023-2

  • Online ISBN: 978-3-642-58602-6

  • eBook Packages: Springer Book Archive

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