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Maturation Phenomenon in Cerebral Ischemia III pp 25–31Cite as

Delayed Gene Expression and Ischemic Brain Injury

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Summary

There is increasing evidence that cerebral ischemic injury occurs at a slower pace than previously believed. Although in areas of severe ischemia tissue damage occurs relatively rapidly, in regions of less-severe ischemia, damage develops over the course of many hours or even days. In this chapter, we review data indicating that inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) are upregulated following focal cerebral ischemia and that the products of their reaction contribute to the delayed progression of ischemic brain damage. Administration of iNOS and COX-2 inhibitors may be a useful therapeutic strategy to selectively target the progression of the brain damage that takes place during the post-ischemic period.

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References

  1. Baird AE, Benfield A, Schlaug G, Siewert B, Lövblad K-O, Edelman RR, Warach S (1997) Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 41: 581–589

    Article  PubMed  CAS  Google Scholar 

  2. Dawson V, Brahmbhatt VL, Mong JA, Dawson TM (1994) Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology 33: 1425–1430

    Article  PubMed  CAS  Google Scholar 

  3. Dereski MO, Chopp M, Knight RA, Rodolosi LC, Garcia JH (1993) The heterogeneous temporal evolution of focal ischemic neuronal damage in the rat. Acta Neuropathol 85: 327–333

    Article  PubMed  CAS  Google Scholar 

  4. Feuerstein GZ, Wang X, Barone FC (1998) Inflammatory mediators and brain injury: the role of cytokines and chemokines in stroke and CNS diseases. In: Ginsberg MD, Bogousslaysky J (eds) Cerebrovascular diseases. Blackwell Science, Cambridge, pp 507–531

    Google Scholar 

  5. Furlan M, Marchal G, Viader F, Derlon J-M, Baron J-C (1996) Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol 40: 216–226

    Article  PubMed  CAS  Google Scholar 

  6. Futaki N, Yoshikawa K, Hamasaka Y, Arai I, Higuchi S, Iizuka H, Otomo S (1993) NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol 24: 105–10

    Article  PubMed  CAS  Google Scholar 

  7. Garcia JH, Liu KF, Yoshida Y, Lian J, Chen S, del Zoppo GJ (1994) Influx of leukocytes and platelets in an evolving brain infarct. Am J Pathol 144: 188–199

    PubMed  CAS  Google Scholar 

  8. Garcia JH, Yoshida Y, Chen H, Li Y, Zhang ZG, Lian J, Chen S, Chopp M (1993) Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am J Pathol 142: 623–635

    PubMed  CAS  Google Scholar 

  9. Garthwaite J, Boulton CL (1995) Nitric oxide signaling in the central nervous system. Ann Rev Physiol 57: 683–706

    Article  CAS  Google Scholar 

  10. Giulian D (1997) Reactive microglia and ischemic injury. In: Welsh KMA, Caplan LR, Reis DJ, Siësjo BK, Weir B (eds) Primer on cerebrovascular diseases. Academic Press, San Diego, pp 117–124

    Chapter  Google Scholar 

  11. Griffith OW, Stuehr DJ (l995) Nitric oxide synthases: properties and catalytic mechanism. Ann Rev Physiol 57: 707–736

    Article  CAS  Google Scholar 

  12. Gross SS, MS Wolin (1995) Nitric oxide: pathophysiological mechanisms. Ann Rev Physiol 57: 737–769

    Article  CAS  Google Scholar 

  13. Heiss WD, Huber M, Fink GR, Herloz K, Pietrzyk U, Wagner R, Weinhard K (1992) Progressive derangement of periinfarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab 12: 193–203

    Article  PubMed  CAS  Google Scholar 

  14. Hewett SJ, Csernansky CA, Choi DW (1994) Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS. Neuron 13: 487–94

    Article  PubMed  CAS  Google Scholar 

  15. Hewett SJ, Muir JK, Lobner D, Symons A, Choi DW (1996) Potentiation of oxygen-glucose deprivation-induced neuronal death after induction of iNOS. Stroke 27: 1586–1591

    Article  PubMed  CAS  Google Scholar 

  16. Iadecola C, Zhang F, Xu X (1995) Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 268: 286–292

    Google Scholar 

  17. Iadecola C, Zhang F, Xu X, Casey R, Ross ME (1995) Inducible nitric oxide synthase gene expression in brain following cerebral ischemia.J Cereb Blood Flow Metab 15: 378–384

    Article  PubMed  CAS  Google Scholar 

  18. Iadecola C, Zhang F, Casey R, Clark HB, Ross ME (1996) Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia. Stroke 27: 1373–1380

    Article  PubMed  CAS  Google Scholar 

  19. Iadecola C, Zhang F, Casey R, Nagayama M, Ross ME (1997) Delayed reduction in ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci 17: 9157–9164

    PubMed  CAS  Google Scholar 

  20. Koroshetz WJ, Moskowitz MA (1996) Emerging treatments for stroke in humans. Trends Pharmacol Sci 17: 227–233

    Article  PubMed  CAS  Google Scholar 

  21. MacMicking JD, Nathan C, Ham G, Chartrain N, Fletcher DS, Trumbauer M, Stevens K, Xie QW, Sokol K, Hutchinson N, Chen H, Mudgett JS (1995) Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81: 641–650

    Article  PubMed  CAS  Google Scholar 

  22. MacMicking ID, Xie QW, Nathan C (1997) Nitric oxide and macrophage function. Annu Rev Immunol 15; 323–350

    Article  PubMed  CAS  Google Scholar 

  23. Marchal G, Beaudouin V, Rioux P, de la Sayette V, Le Doze F, Viader F, Derlon J-M, Baron JC (1996) Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke. Stroke 27: 599–606

    Article  PubMed  CAS  Google Scholar 

  24. Nagayama M, Zhang F, Iadecola C (1998) Delayed treatment with aminoguanidine reduces focal cerebral ischemic damage and enhances neurological recovery in rats. J Cereb Blood Flow Metab (in press)

    Google Scholar 

  25. Nogawa S, Zhang F, Ross ME, Iadecola C (1997) Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17: 2746–2755

    PubMed  CAS  Google Scholar 

  26. Peterson PK, Hu S, Anderson WR, Chao CC (1994) Nitric oxide production and neurotoxicity mediated by activated microglia from human versus mouse brain. J Infect Dis 170: 457–460

    Article  PubMed  CAS  Google Scholar 

  27. Salvemini D (1997) Regulation of cyclooxygenase enzymes by nitric oxide. Cell Mol Life Sci 53: 576–82

    Article  PubMed  CAS  Google Scholar 

  28. Salvemini D, Misko TP, Masferrer JL, Seibert K, Currie MG, Needleman P (1993) Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci U S A 90: 7240–7244

    Article  PubMed  CAS  Google Scholar 

  29. Salvemini D, Seibert K, Masferrer JL, Misko TP, Currie MG, Needleman P (1994) Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J Clin Invest 93: 1940–1947

    Article  PubMed  CAS  Google Scholar 

  30. Seibert K, Masferrer J, Zhang Y, Gregory S, Olson G, Hauser S, Leahy K, Perkins W, Isakson P (1995) Mediation of inflammation by cyclooxygenase-2. Agents Actions Suppl 46: 41–50

    PubMed  CAS  Google Scholar 

  31. Sessa W C (1994) The nitric oxide synthase family of proteins. J Vasc Res 31: 131–343

    Article  PubMed  CAS  Google Scholar 

  32. Smith WL, Meade EA, DeWitt DL (1994) Pharmacology of prostaglandin endoperoxide synthase isozymes-1 and -2. Ann N Y Acad Sci 714: 136–142

    Article  PubMed  CAS  Google Scholar 

  33. Vodovotz Y, Kwon NS, Pospischil M, Manning J, Paik J, Nathan C (1994) Inactivation of nitric oxide synthase after prolonged incubation of mouse macrophages with IFN-gamma and bacterial lipopolysaccharide. J Immunol 152: 4110–4118

    PubMed  CAS  Google Scholar 

  34. Warach S, Gaa I, Siewert B, Wielopolski PI, Edelman RR (1995) Acute human stroke studied by whole brain echo planar diffusion-weighted magnetic resonance imaging. Ann Neurol 37: 231–241

    Article  PubMed  CAS  Google Scholar 

  35. Welch KMA, Windham J, Knight RA, Nagesh V, Hugg JW, Jacobs M, Peck D, Booker P, Deresky MO, Levine SR (1995) A model to predict the histopathology of human stroke using diffusion and T2-weighted magnetic resonance imaging. Stroke 26: 1983–1989

    Article  PubMed  CAS  Google Scholar 

  36. Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, Worley PF (1993) Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11: 371–386

    Article  PubMed  CAS  Google Scholar 

  37. Zea Longa E, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rat. Stroke 20: 84–91

    Article  Google Scholar 

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Authors
  1. C. Iadecola
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  2. M. E. Ross
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  3. F. Zhang
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  4. S. Nogawa
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  5. M. Nagayama
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  6. T. Nagayama
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shi, Tokyo 180, Japan

    Umeo Ito

  2. Dipartimenti di Scienze Neurologiche, Università di Roma “La Sapienza”, Viale dell’University 30, 00185, Roma, Italy

    Cesare Fieschi

  3. Istituto Neurologico Mediterraneo, NEUROMED Research Laboratories, Via Atinense 18, 86077, Pozzilli (Isernia), Italy

    Francesco Orzi

  4. Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113 Tokyo, Japan

    Toshihiko Kuroiwa

  5. National Institutes of Health, Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, Bethesda, MD, 20892-4128, USA

    Igor Klatzo

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© 1999 Springer-Verlag Berlin Heidelberg

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Iadecola, C., Ross, M.E., Zhang, F., Nogawa, S., Nagayama, M., Nagayama, T. (1999). Delayed Gene Expression and Ischemic Brain Injury. In: Ito, U., Fieschi, C., Orzi, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58602-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-58602-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65023-2

  • Online ISBN: 978-3-642-58602-6

  • eBook Packages: Springer Book Archive

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