Summary
Cardiac arrest and resuscitation results in reperfusion injury, which produces delayed selective neuronal cell loss and, in many cases, results in delayed mortality due to cerebral edema. We have shown that, in a rat model of reversible global ischemia of 12-min duration, significant cerebral edema occurs in the brain stem after 24 h. We found that vascular endothelial growth factor (VEGF) protein levels are significantly elevated in brain after 24 h and 48 h of reperfusion. We propose that increased VEGF expression is responsible for blood-brain barrier breakdown and vasogenic edema.
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© 1999 Springer-Verlag Berlin Heidelberg
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Pichiule, P., Chávez, J.C., Xu, K., LaManna, J.C. (1999). Upregulation of Vascular Endothelial Growth Factor Protein Levels in Global Ischemia Induced by Cardiac Arrest and Resuscitation in Rat Brain. In: Ito, U., Fieschi, C., Orzi, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58602-6_14
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DOI: https://doi.org/10.1007/978-3-642-58602-6_14
Publisher Name: Springer, Berlin, Heidelberg
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