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Rho Family Proteins and Regulation of the Actin Cytoskeleton

  • Chapter
Cytoskeleton and Small G Proteins

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 22))

Abstract

The actin cytoskeleton plays an essential role in many cellular functions, including cell motility and migration, cell division, intracellular transport processes, and phagocytosis. In order to mediate these diverse processes, the actin cytoskeleton is highly dynamic and can be rapidly reorganized in response to a variety of different signals. Actin reorganization is an early response of cells to many growth factors, cytokines and lipid mediators (Ridley 1994). In addition, the composition of the extracellular matrix, the extent of cell spreading and interactions with other cells play an important role in regulating actin organization (Ruoslahti 1997; Schwartz 1997). These different extrinisic signals combine to regulate cellular responses involving the cytoskeleton, and may also induce long-term changes by altering the transcription of cytoskeletal proteins or regulatory proteins. Finally, intrinsic signals during the cell cycle lead to reorganization of actin filaments during mitosis followed by formation and contraction of the actin-based contractile ring at cytokinesis (Ridley 1995).

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1P 8BT, UK

    Anne J. Ridley

  2. Department of Biochemistry and Molecular Biology, University College of London, Gower Street, London, UK

    Anne J. Ridley

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  1. Anne J. Ridley
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  1. Institute of Molecular Genetics of Montpellier CNRS, University of Montpellier II, 1919 Route de Mende, Montpellier Cedex 5, F-34293, France

    Philippe Jeanteur

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© 1999 Springer-Verlag Berlin Heidelberg

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Ridley, A.J. (1999). Rho Family Proteins and Regulation of the Actin Cytoskeleton. In: Jeanteur, P. (eds) Cytoskeleton and Small G Proteins. Progress in Molecular and Subcellular Biology, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58591-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-58591-3_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63659-2

  • Online ISBN: 978-3-642-58591-3

  • eBook Packages: Springer Book Archive

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