Skip to main content
SpringerLink
Log in

gp49: An Ig-like Receptor with Inhibitory Properties on Mast Cells and Natural Killer Cells

  • Chapter
Immunoreceptor Tyrosine-based Inhibition Motifs

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 244))

  • 123 Accesses

Abstract

The activation of human natural killer (NK) cells is under tight negative control of killer cell Ig-like receptors (KIR) specific for HLA class I. Recently, several new receptor families were identified which share structural features with KIR but are expressed in various different cell types of the immune system. One of these receptor families, the gp49 glycoproteins, are expressed on mouse mast cells and NK cells where they may deliver dominant inhibitory signals participating in the regulation of cellular effector functions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arm JP, Gurish MF, Reynolds DS, Scott HC, Gartner CS, Austen KF, Katz HR (1991) Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily. J Biol Chem 266:15966–15973

    PubMed  CAS  Google Scholar 

  • Arm JP, Nwankwo C, Austen KF (1997) Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49Bl inhibitory receptor. J Immunol 159:2342–2349

    PubMed  CAS  Google Scholar 

  • Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet J-P, Abraham RT, Leibson PJ (1996) Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity 5:629–638

    Article  PubMed  CAS  Google Scholar 

  • Biron CA (1997) Activation and function of natural killer cell responses during viral infections. Curr Opin Immunol 9:24–34

    Article  PubMed  CAS  Google Scholar 

  • Borges L, Hsu M-L, Fanger N, Kubin M, Cosman D (1997) A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC Class I molecules. J Immunol 159:5192–5196

    PubMed  CAS  Google Scholar 

  • Burshtyn DN, Scharenberg AM, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet J-P, Long EO (1996) Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity 4:77–85

    Article  PubMed  CAS  Google Scholar 

  • Burshtyn DN, Long EO (1997) Regulation through inhibitory receptors: lessons from natural killer cells. Trends Cell Biol 7:473–479

    Article  PubMed  CAS  Google Scholar 

  • Burshtyn DN, Yang W, Yi T, Long EO (1997) A novel phosphotyrosine motif with a critical amino acid at position-2 for the SH2 domain-mediated activation of the tyrosine phosphatase SHP-1. J Biol Chem 272:13066–13072

    Article  PubMed  CAS  Google Scholar 

  • Cambiaggi A, Verthuy C, Naquet P, RomagnĂ© F, Ferrier P, Biassoni R, Moretta A, Moretta L, Vivier E (1997) NK-cell acceptance of H-2 mismatch bone-marrow grafts in transgenic mice expressing HLA-Cw3 specific killer-cell inhibitory receptor (CD158b). Proc Natl Acad Sci (USA) 94: 8088–8092

    Article  CAS  Google Scholar 

  • Castells MC, Wu X, Arm JP, Austen KF, Katz HR (1994) Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. J Biol Chem 269:8393–8401

    PubMed  CAS  Google Scholar 

  • Colonna M, Samaridis J (1995) Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 268:405–408

    Article  PubMed  CAS  Google Scholar 

  • Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu M-L (1997) A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecule. Immunity 7:273–282

    Article  PubMed  CAS  Google Scholar 

  • DaĂ«ron M, Malbec O, Latour S, Arock M, Fridman WH (1995) Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. J Clin Invest 95:577–585

    Article  PubMed  Google Scholar 

  • DaĂ«ron M (1997) Fc receptor biology. Annu Rev Immunol 15:203–234

    Article  PubMed  Google Scholar 

  • Echtenacher B, Mannel DN, Hultner L (1996) Critical protective role of mast cells in a model of acute septic peritonitis. Nature 381:75–77

    Article  PubMed  CAS  Google Scholar 

  • Flemming TJ, Donnadieu E, Song CH, Van Laethem F, Galli SJ, Kinet J-P (1997) Negative regulation of FcεRI-mediated degranulation by CD81. J Exp Med 186:1307–1314

    Article  Google Scholar 

  • Gupta N, Scharenberg AM, Burshtyn DN, Wagtmann N, Lioubin MN, Rohrschneider LR, Kinet J-P, Long EO (1997) Negative signaling pathways of the killer cell inhibitory receptor and FcÎłRIIbl require distinct phosphatases. J Exp Med 186:473–478

    Article  PubMed  CAS  Google Scholar 

  • Guthmann MD, Tal M, Pecht I (1995) A secretion inhibitory signal transduction molecule on mast cells is another C-type lectin. Proc Natl Acad Sci USA 92:9397–9401

    Article  PubMed  CAS  Google Scholar 

  • Hayami K, Fukuta D, Nishikawa Y, Yamashita Y, Inui M, Ohyama Y, Hikida M, Ohmori H, Takai T (1997) Molecular cloning of a novel murine cell-surface receptor glycoprotein homologous to killer cell inhibitory receptors. J Biol Chem 272:7320–7327

    Article  PubMed  CAS  Google Scholar 

  • Katz HR, Vivier E, Castells MC, McCormick MJ, Chambers JM, Austen KF (1996) Mouse mast cell gp49Bl contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation upon ligation with FcεRI. Proc Natl Acad Sci (USA) 93:10809–10814

    Article  CAS  Google Scholar 

  • Kubagawa H, Burrows PD, Cooper MD (1997) A novel pair of immunoglobulin-like receptors expressed by B-cells and myeloid cells. Proc Natl Acad Sci (USA) 94:5261–5266

    Article  CAS  Google Scholar 

  • Kuroiwa A, Yamashita Y, Inui M, Yuasa T, Ono M, Nagabukuro A, Matsuda Y, Takai T (1998) Association of tyrosine phosphatase SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49Bl, and chromosomal assignment of the gene. J Biol Chem 273:1070–1074

    Article  PubMed  CAS  Google Scholar 

  • Lanier LL (1998) Natural killer cell receptors. Ann Rev Immunol 16:359–393

    Article  CAS  Google Scholar 

  • Lanier LL, Corliss B, Wu J, Phillips JH (1998a) Association of DAP-12 with activating CD94/NKG2 C natural killer cell receptors. Immunity 8:693–701

    Article  PubMed  CAS  Google Scholar 

  • Lanier LL, Corliss BC, Wu J, Leong C, Phillips JH (1998b) Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating natural killer cells. Nature 391:703–707

    Article  PubMed  CAS  Google Scholar 

  • LeBlanc PA, Biron CA (1984) Mononuclear phagocyte maturation: a cytotoxic monoclonal antibody reactive with postmonoblast stages. Cell Immunol 83:242–254

    Article  PubMed  CAS  Google Scholar 

  • Ljunggren H-G, Kärre K (1990) In search of the “missing self”: MHC molecules and natural killer cell recognition. Immunol Today 11:237

    Article  PubMed  CAS  Google Scholar 

  • Malaviya R, Ikeda T, Ross E, Abraham SN (1996) Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature 381:77–80

    Article  PubMed  CAS  Google Scholar 

  • Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland E, Lanier LL, Phillips JH (1997) LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 7:283–290

    Article  PubMed  CAS  Google Scholar 

  • Olcese L, Cambiaggi A, Semenzato G, Bottino C, Moretta A, Vivier E (1997) Killer-cell activatory receptors for MHC Class I molecules are included in a multimeric complex expressed by human killer cells. J Immunol 158:5083–5086

    PubMed  CAS  Google Scholar 

  • Ono M, Okada H, Bolland S, Yanagi S, Kurosaki T, Ravetch JV (1997) Deletion of SHIP or SHP-1 reveals two distincts pathways for inhibitory signaling. Cell 90:293–301

    Article  PubMed  CAS  Google Scholar 

  • Rojo S, Burshtyn DN, Long EO, Wagtmann N (1997) Type I transmembrane receptor with inhibitory function in mouse mast cells and natural killer cells. J Immunol 158:9–12

    PubMed  CAS  Google Scholar 

  • Samaridis J, Colonna M (1997) Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. Eur J Immunol 27:660–665

    Article  PubMed  CAS  Google Scholar 

  • Smith KM, Wu J, Bakker ABH, Phillips JH, Lanier LL (1998) Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J Immunol 161:7–10

    PubMed  CAS  Google Scholar 

  • Trinchieri G (1995) Natural killer cells wear different hats: effector cells of innate resistance and regulatory cells of adaptive immunity and of hematopoiesis. Semin Immunol 7:83–88

    Article  PubMed  CAS  Google Scholar 

  • Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati M, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (1995a) Molecular clones of p58 natural killer cell receptor reveal immunoglobulin-related molecules with diversity in both the extra-and the intracellular domains. Immunity 2:439–449

    Article  PubMed  CAS  Google Scholar 

  • Wagtmann N, Rajogopalan S, Winter CC, Peruzzi M, Long EO (1995b) Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer. Immunity 3:801–809

    Article  PubMed  CAS  Google Scholar 

  • Wagtmann N, Rojo S, Eichler E, Mohrenweiser H, Long EO (1997) A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors. Curr Biol 7:615–618

    Article  PubMed  CAS  Google Scholar 

  • Wang LL, Mehta IK, LeBlanc PA, Yokoyama WM (1997) Mouse natural killer cells express gp49Bl, a structural homologue of human killer inhibitory receptors. J Immunol 158:13–17

    PubMed  CAS  Google Scholar 

  • Winter CC, Long EO (1997) A single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes. J Immunol 158:4026–4028

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre d’Immunologie, INSERM/CNRS de Marseille-Luminy, Case 906, 13288, Marseille, cedex 09, France

    N. Wagtmann

Authors
  1. N. Wagtmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratoire d’Immunologie Cellulaire et Clinique INSERM U.255, Institut Curie, 26 rue d’Ulm, F-75005, Paris, France

    Marc Daëron M.D. Ph.D.

  2. Centre d’Immunologie INSERM-CNRS de Marseille Luminy, Institut Universitaire de France, Parc Scientifique de Luminy-Case 906, F-13288, Marseille Cedex 9, France

    Eric Vivier DUM, Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Wagtmann, N. (1999). gp49: An Ig-like Receptor with Inhibitory Properties on Mast Cells and Natural Killer Cells. In: Daëron, M., Vivier, E. (eds) Immunoreceptor Tyrosine-based Inhibition Motifs. Current Topics in Microbiology and Immunology, vol 244. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58537-1_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58537-1_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63634-9

  • Online ISBN: 978-3-642-58537-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation