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Inhibitory Role of Murine Ly49 Lectin-like Receptors on Natural Killer Cells

  • Chapter
Immunoreceptor Tyrosine-based Inhibition Motifs

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 244))

Abstract

Natural killer (NK) cells are an essential component of the innate immune system, both as cytotoxic effectors and as a source of cytokines that modulate the activity of other cells, including T cells and macrophages. While the molecular mechanisms involved in NK cell activation are not completely understood, significant progress has been made in the characterization of the inhibition of NK cell-mediated lysis. It has become clear that the interaction between target cell MHC class I molecules and specific MHC class I-binding inhibitory receptors on NK cells interrupts the process of NK cell activation (Yokoyama 1998a; Lanier 1998). The physiological significance of this type of recognition finds its best explanation in the “missing self” hypothesis (Ljunggren and Kärre 1990), which suggests that NK cells recognize and kill cells that have lost normal expression of MHC class I molecules, e.g. during viral infections or malignant processes.

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Author notes

  1. M. Salcedo

    Present address: IDM (Immune Designed Molecules), 75011, Paris, France

Authors and Affiliations

  1. Unité de Biologie Moléculaire du Gène, INSERM U277, Institut Pasteur, 75015, Paris, France

    M. Salcedo

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  1. M. Salcedo
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Editor information

Editors and Affiliations

  1. Laboratoire d’Immunologie Cellulaire et Clinique INSERM U.255, Institut Curie, 26 rue d’Ulm, F-75005, Paris, France

    Marc Daëron M.D. Ph.D.

  2. Centre d’Immunologie INSERM-CNRS de Marseille Luminy, Institut Universitaire de France, Parc Scientifique de Luminy-Case 906, F-13288, Marseille Cedex 9, France

    Eric Vivier DUM, Ph.D.

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© 1999 Springer-Verlag Berlin Heidelberg

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Salcedo, M. (1999). Inhibitory Role of Murine Ly49 Lectin-like Receptors on Natural Killer Cells. In: Daëron, M., Vivier, E. (eds) Immunoreceptor Tyrosine-based Inhibition Motifs. Current Topics in Microbiology and Immunology, vol 244. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58537-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-58537-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63634-9

  • Online ISBN: 978-3-642-58537-1

  • eBook Packages: Springer Book Archive

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