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The Unexpected Complexity of FcγRIIB Signal Transduction

  • Chapter
Immunoreceptor Tyrosine-based Inhibition Motifs

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 244))

Abstract

Recent studies have defined a family of modulatory receptors and coreceptors that function to inhibit the transduction of certain activating signals. These receptors, which now number more than 75, are structurally similar and employ similar signaling effectors, but are found in diverse cellular systems (for review see Cambier 1997; Vely and Vivier 1997; Lanier 1998; Yokoyama 1998). The longest-recognized and most extensively studied member is FcγRIIB, a low-affinity receptor for immunoglobulin G (IgG) constant regions that occurs in three alternatively spliced isoforms which differ only in their cytoplasmic tail sequence (see Fig. 1) (Fridman, Bonnerot et al. 1992; Latour, Fridman et al. 1996). All isoforms mediate transduction of inhibitory signals. The FcγRIIB 1 isoform is expressed by B lymphocytes throughout the lineage, as well as by certain mast cells, other granulocytes, and activated T cells. When coaggregated with antigen receptors, e.g. BCR and FcɛRI, by immune complexes containing IgG antibodies, FcγRIIB1 mediate inhibition of antigen receptor-mediated B cell blastogenesis and proliferation, and divert the response to apoptosis (Chan and Sinclair 1971; Phillips and Parker 1983; Phillips and Parker 1984; Ashman, Peckham et al. 1996; Ono, Okada et al. 1997). Other prominent members of the inhibitory receptor family are the killer inhibitory receptors (KIR) that function to block target cell killing by natural killer (NK) cells, certain T cells (Lanier 1998; Yokoyama 1998), and CTLA4, that functions late in the T cell response to attenuate clonal outgrowth (Thompson and Allison 1997).

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Authors and Affiliations

  1. Division of Basic Sciences, Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson Street, Denver, CO, 80206, USA

    J. C. Cambier, D. Fong & I. Tamir

  2. Department of Immunology, University of Colorado Health Sciences Center, Denver, CO, 80206, USA

    J. C. Cambier, D. Fong & I. Tamir

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  1. J. C. Cambier
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  2. D. Fong
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  3. I. Tamir
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Editors and Affiliations

  1. Laboratoire d’Immunologie Cellulaire et Clinique INSERM U.255, Institut Curie, 26 rue d’Ulm, F-75005, Paris, France

    Marc Daëron M.D. Ph.D.

  2. Centre d’Immunologie INSERM-CNRS de Marseille Luminy, Institut Universitaire de France, Parc Scientifique de Luminy-Case 906, F-13288, Marseille Cedex 9, France

    Eric Vivier DUM, Ph.D.

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© 1999 Springer-Verlag Berlin Heidelberg

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Cambier, J.C., Fong, D., Tamir, I. (1999). The Unexpected Complexity of FcγRIIB Signal Transduction. In: Daëron, M., Vivier, E. (eds) Immunoreceptor Tyrosine-based Inhibition Motifs. Current Topics in Microbiology and Immunology, vol 244. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58537-1_4

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  • DOI: https://doi.org/10.1007/978-3-642-58537-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63634-9

  • Online ISBN: 978-3-642-58537-1

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