Abstract
A decade has already passed since we discovered, essentially by serendipity, the membranal glycoprotein later named MAst cell Function-associated Antigen (MAFA). While trying to identify the still elusive Ca2+ channel responding to the type 1 Fcɛ receptor (FcɛRI) stimulus, a series of monoclonal antibodies (mAb) were raised to the rat mucosal-type mast cells of the RBL-2H3 line. One of these mAbs, G63, caused a dose-dependent inhibition of the secretory response to the FcɛRI stimulus and was shown to bind to a membranal protein which we proceeded to isolate and characterize (Ortega-Soto and Pecht 1988).
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Xu, R., Pecht, I. (1999). The Mast Cell Function-Associated Antigen, a New Member of the ITIM Family. In: Daëron, M., Vivier, E. (eds) Immunoreceptor Tyrosine-based Inhibition Motifs. Current Topics in Microbiology and Immunology, vol 244. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58537-1_14
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DOI: https://doi.org/10.1007/978-3-642-58537-1_14
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