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Interactions of LIRs, a Family of Immunoreceptors Expressed in Myeloid and Lymphoid Cells, with Viral and Cellular MHC Class I Antigens

  • Chapter
Immunoreceptor Tyrosine-based Inhibition Motifs

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 244))

Abstract

Human cytomegalovirus (hCMV) infects 70%–90% of adults (Wentworth and Alexander 1971). Evidence of CMV infection, but not other common viruses such as measles or influenza, has been found in the remote Tiriyo Indian tribe in Brazil, suggesting that CMV has been present in the human population for a long time (Gold and Nankervis 1976). hCMV infection usually occurs early in life with only mild and subclinical disease, followed by virus latency that can last for the lifetime of immunocompetent individuals. However, reactivation of the virus can occur in immuno-compromised patients, such as AIDS and transplant patients, and become a major cause of morbidity and mortality.

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Author information

Authors and Affiliations

  1. Immunex Corporation, 51 University Street, Seattle, WA, 98101-2936, USA

    L. Borges, N. Fanger & D. Cosman

Authors
  1. L. Borges
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  2. N. Fanger
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  3. D. Cosman
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Editor information

Editors and Affiliations

  1. Laboratoire d’Immunologie Cellulaire et Clinique INSERM U.255, Institut Curie, 26 rue d’Ulm, F-75005, Paris, France

    Marc Daëron M.D. Ph.D.

  2. Centre d’Immunologie INSERM-CNRS de Marseille Luminy, Institut Universitaire de France, Parc Scientifique de Luminy-Case 906, F-13288, Marseille Cedex 9, France

    Eric Vivier DUM, Ph.D.

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© 1999 Springer-Verlag Berlin Heidelberg

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Borges, L., Fanger, N., Cosman, D. (1999). Interactions of LIRs, a Family of Immunoreceptors Expressed in Myeloid and Lymphoid Cells, with Viral and Cellular MHC Class I Antigens. In: Daëron, M., Vivier, E. (eds) Immunoreceptor Tyrosine-based Inhibition Motifs. Current Topics in Microbiology and Immunology, vol 244. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58537-1_11

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  • DOI: https://doi.org/10.1007/978-3-642-58537-1_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63634-9

  • Online ISBN: 978-3-642-58537-1

  • eBook Packages: Springer Book Archive

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