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Retinoic Acid Synthesis and Metabolism

  • Chapter
Retinoids

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 139))

Abstract

It is well known from the early literature that liver alcohol dehydrogenase catalyzes the oxidation of retinol to retinal (Blaner and Olson 1994). Similarly, it was established from early work that several members of the aldehyde dehydrogenase family of enzymes are able to catalyze irreversibly the oxidation of retinal to retinoic acid (Blaner and Olson 1994). Thus,it has long been understood that retinoic acid synthesis from its precursor retinol involves a two step oxidation that resembles the oxidation of ethanol to acetic acid.

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Authors
  1. W. S. Blaner
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  2. R. Piantedosi
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  3. A. Sykes
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  4. S. Vogel
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Editors and Affiliations

  1. Department of Food Toxicology Center of Food Science, School of Veterinary Medicine, Bischofholer Damm, D-30173, Hannover, Germany

    Heinz Nau

  2. Department of Medicine Division of Preventive Medicine & Nutrition, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, NY, 10032, USA

    William S. Blaner Ph.D.

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Blaner, W.S., Piantedosi, R., Sykes, A., Vogel, S. (1999). Retinoic Acid Synthesis and Metabolism. In: Nau, H., Blaner, W.S. (eds) Retinoids. Handbook of Experimental Pharmacology, vol 139. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58483-1_4

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  • DOI: https://doi.org/10.1007/978-3-642-58483-1_4

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