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Genetische Aspekte der Störungen in der Frühschwangerschaft

  • Gholamali Tariverdian
  • Marion Paul
Chapter

Zusammenfassung

Etwa 15% aller bewußt registrierten Schwangerschaften enden in einem Spontanabort. Falls man auch die Präimplantationsphase mit berücksichtigt, wird von einer Abortrate von 30–50% ausgegangen. Der verhaltene Abort (missed abortion) macht ca. 90% der Gesamtabortrate aus. Beim klinischen Bild eines Abortus imminens ist bei der Hälfte der Fälle von einer Missed abortion auszugehen (Berle 1988).

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Literatur

  1. Berle P (1988) Spontanabortrate in der Frühschwangerschaft. Gynäkologe 21:98Google Scholar
  2. Brackertz W (1983) Zur Genetik der Blasenmolen. Geburtsh Frauenheilkd 43:461–468CrossRefGoogle Scholar
  3. Diedrich U, Hansmann I, Janke D, Opitz O, Probeck HD (1983) Chromosome anomalies in 136 couples with a history of recurrent abortions. Hum Genet 65:48–52PubMedCrossRefGoogle Scholar
  4. Eiben B, Bartels I, Bähr-Porsch S et al. (1990) Cytogenetic analysis of 750 spontaneous abortions with the direct-preparation method of chorionic villi and its implications for studying genetic causes of pregnancy wastage. Am J Hum Genet 47:656–663PubMedGoogle Scholar
  5. Gilmore DH, McNay MB (1985) Spontaneous fetal loss rate in early pregnancy. Lancet I:107CrossRefGoogle Scholar
  6. Golbus SM, Voughman WD, Epstein J et al. (1979) Prenatal diagnosis in 300 amniocenteses. N Engl J Med 300:157–163PubMedCrossRefGoogle Scholar
  7. Hassold T (1980) A cytogenetic of repeated abortions. Am J Hum Genet 32:723–730PubMedGoogle Scholar
  8. Hassold T, Chen N, Funkhouser J et al. (1980) A cytogenetic study of 1000 spontaneous abortions. Ann Hum Gen 44:151–178CrossRefGoogle Scholar
  9. Hook EB (1992) Chromosome abnormalities: prevalence, risks and recurrence. In: Brock JM et al. (eds) Prenatal diagnosis and screening. Churchill Livingstone, Edinburgh, pp 351–392Google Scholar
  10. Kircheisen R, Schroeder-Kurth T (1991) Familiäres Blasenmolen-Syndrom and genetische Aspekte dieser Trophoblastentwicklung. Geburtsh Frauenheilkd 51:569–571CrossRefGoogle Scholar
  11. Leridon H (1973) Démographie des échecs de la reproduction. In: Bone A, Thibault C (eds) Les accidents chromosomiques de la reproduction. Inserm, Paris, pp 13–27Google Scholar
  12. McFadyen IR (1984) Medical Research Council Meeting to discuss the evaluation of the safety of chorion biopsy techniques, London, March 30thGoogle Scholar
  13. McFadyen IR (1985) Missed abortion and later spontaneous abortion in pregnancies clinically normal of 7–12 weeks. Eur J Obstet Gynecol Reprod Biol 20:381–384PubMedCrossRefGoogle Scholar
  14. McFadyen IR (1989) Early fetal loss. In: Rodeck CH (ed) Fetal medicine. Blackwell, OxfordGoogle Scholar
  15. Mortimer G (1990) Hydatiform mole. In: Buyse ML (ed) Birth defects Encyclopedia. Blackwell, Oxford, pp 884–886Google Scholar
  16. Pantzar JT, Allanson JE, Kalousek DK, Polland BJ (1984) Cytogenetic findings in 318 couples with repeated spontaneous abortions: a review of experience in British Columbia. Am J Med Genet 17:615–620PubMedCrossRefGoogle Scholar
  17. Poland BI, Miller JR, Jones DC, Trimble BK (1977) Reproductive counselling in patients who have had a spontaneous abortion. Am J Obstet Gynecol 127:685–691PubMedGoogle Scholar
  18. Sant-Cassia LJ, MacPherson MBA, Tyack AJ (1984) Mid trimester amniocentesis: is it safe? A single centre controlled prospective study of 517 consecutive amniocenteses. Br J Ob-stet Gynecol 91:736–744CrossRefGoogle Scholar
  19. Sperling K (1983) Chromosomen-Anomalien beim Menschen. Häufigkeit und Entstehung. Biol I U Z 13:144–156CrossRefGoogle Scholar
  20. Sperling K, Wegner RD (1995) Ätiologie und Pathogenese chromosomal bedingter embryofetaler Fehlbildungen und Spontanaborte. In: Becker R, Fuhrmann W, Holzgreve W, Sperling K (Hrsg) Pränatale Diagnostik und Therapie. Wissenschaftliche Verlagsgesellschaft, StuttgartGoogle Scholar
  21. Stoll C (1981) Cytogenetic findings in 122 couples with recurrent abortions. Hum Genet 57:101–103PubMedCrossRefGoogle Scholar
  22. Warburton D, Kleine J, Stein Z, Hutzler M, Clim A, Hassold T (1987) Does the karyotype of a spontaneous abortion predict the karyotype of a subsequent abortion? Evidence from 273 women with two karyotyped spontaneous abortions. Am J Hum Genet 41:465–483PubMedGoogle Scholar
  23. Warburton D, Byrne J, Canki N (1991) Chromosome anomalies and prenatal development: an atlas. Oxford University Press (Oxford Monographs on Medical Genetics 21)Google Scholar
  24. Wieacker PF (1994) Genetik in Gynäkologie und Geburtshilfe. Enke, Stuttgart (Bücherei des Frauenarztes 47)Google Scholar
  25. Wilson RD, Kendrick V, Wittmann BK, McGillivray BC (1984) Risk of spontaneous abortion in ultrasonically normal pregnancies. Lancet I:920–921CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Gholamali Tariverdian
    • 1
  • Marion Paul
    • 2
  1. 1.Institut für Humangenetik der Universität Heidelberg Genetische PoliklinikHeidelbergGermany
  2. 2.Gemeinschaftspraxis Drs. med. M. Paul, M. Chwat, M. GastMannheimGermany

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