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From Polyphosphates to Bisphosphonates and Their Role in Bone and Calcium Metabolism

  • Chapter
Inorganic Polyphosphates

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 23))

Abstract

This review will first describe the results obtained for the most part about 30-40 years ago on the effects and the possible role of pyrophosphate in bone and calcium metabolism. In a second part we shall describe how these results led to the development of a new class of compounds which are analogues of pyrophosphate, the bisphosphonates. The latter are today the main therapeutic drugs in the treatment of bone diseases characterized by increased osteolysis, such as Paget’s disease, tumor bone disease, and osteoporosis. Lastly, the possibility of using and extrapolating the intracellular effects of these compounds on the possible action of pyrophosphate and polyphosphates in the cell will be discussed.

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    H. Fleisch

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Fleisch, H. (1999). From Polyphosphates to Bisphosphonates and Their Role in Bone and Calcium Metabolism. In: Schröder, H.C., Müller, W.E.G. (eds) Inorganic Polyphosphates. Progress in Molecular and Subcellular Biology, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58444-2_10

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