Abstract
In China, the genus Salvia consists of 78 species, 24 varieties, and 8 forms, and is distributed throughout, especially in areas of southwestern such as the Sichivan, Yunnan, and Xizang provinces (Huang et al. 1981). Many Salvia species have been screened as possible sources of tanshinones, for example, S. przewalskii var. mandarinorum, S. przenwalskii, S. miltiorrhiza, S. yunnanensis, and S. bowleyana contain more tanshinone II-A, and S. przewalskii, S. miltiorrhiza, S. yunnanensis, S. digitaloides, and S. kiangsiensis more tanshinone I, in the ten Salvia species studied (Huang et al. 1980). Among them, S. miltiorrhiza Bunge is a well-known traditional Chinese medicinal plant. The roots of this plant, Tan-shen, are widely used in China for treatment of hematologic and cardiovascular disorders (Guo 1992).
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References
Berlin J, Mollenschott C, Greidziak N, Erdogan S, Kuzovkina I (1990) Affecting secondary product formation in suspension and hairy root cultures - a comparison. In: Nijkamp HJJ, Van der Fias LHW, van Aartrijk J (eds) Progress in plant cellular and molcular biology. Kluwer, Dordrecht, pp 763–768
Dräger B, Schaal A (1992) Pseudotropine formation and calystegins in Atropa belladonna root cultures. Int Symp Phytochem and Agricult, Wageningen, April 22–24, 1992
Guo JX (ed) (1992) Research and clinical application of Tan-shen. China Medicine and Pharmacy Science Press, Beijing
Hooykaas PJJ, Klapwijk PM, Nuti MP, Schelperoort RA, Rosch A (1977) Transfer of the Agrobacterium turnefaciens Ti plasmid to avirulent agribacteria and to Rhizobium ex planta. J Gen Microbiol 98:477–484
Hu ZB, Alfermann AW (1993) Diterpenoid production in hairy root cultures of Salvia miltiorrhiza Phytochemistry 32:699–703
Huang XL, Yang BJ, Haung HZ, Xu Y, Hu ZB (1980) Studies on the active principles of Dan-shen III. Searching for plant resources containing tanshinone II-A. Acta Bot Sin 22: 98–100
Huang XL, Yang BJ, Hu ZB (1981) Diterpene quinone of Salvia Linn. and their taxonomic signification. Acta Phytotaxon Sin 19:421–433
Huang LD, Hu ZB, Liu D (1997) Production of water-soluble phenolic acid compounds in hairy root of Salvia miltiorrhiza. Plant Physiol Commun 33:259–261
Li Y, Gu ML, Guo JX (1981) Studies on chinese drugs for coronary heart disease Ill. The tissue cultures of salvia miltiorrhiza and thin layer chromatography of its callus. Acta Acad Med Prim Shanghai 8:191–196
Liu P, Mizoguzhi Y, Morizawa S (1993) Anti liver fibrosis action of magnesium-salvianolic acid B on Ccl4-induced rats. Traditional Chinese Med Acta 8 (Suppl):65–67
Mathews H, Bharatha N, Litz RE, Narayanan KR, Rao PS, Bhatia CR (1990) The promotion of Agrobacterium mediated transformation in Atropa belladonna L. by acetosyringone. J Plant Physiol 136:404–409
Miyasaka H, Nasu M, Yamamoto T, Endo Y, Yoneda K (1986a) Regulation of ferruginol and cryptotanshinone biosynthesis in cell suspension cultures of Salvia miltiorrhiza. Phytochemistry 25:637–640
Miyasaka H, Nasu M, Yamamoto T, Endo Y, Yoneda K (1986b) Production of cryptotanshinone and ferruginol by immobilized cultured cells of Salvia miltiorrhiza. Phytochemistry 25: 1621–1624
Murashige T, Skoog F (1962) A revised medium for rapid growth and bio-assays with tobacco tissue cultures. Physiol Plant 15:473–497
Okamura N, Kobayashi K, Yagi A, Kitazawa T, Shimomura K (1991) High-performance liquid chromatography of abietane-type compounds. J Chromatogr 542:317–326
Ooms G, Karp A, Burrell MM, Twell D, Roberts J (1985) Genetic modification of potato development using Ri T-DNA. Theor Appl Genet 70:440–446
Shaw ML, Conner AJ, Lancaster JE, Williams MK (1988) Quantitations of nopaline and octopine in plant tissue using Sakaguchi’s reagent. Plant Mol Biol Rep 6:155–164
Shimomura K, Kitazawa T, Okamura N, Yagi A (1991) Tanshinone production in adventitious roots and regenerates of Salvia miltiorrhiza. J Nat Prod 54:1583–1587
Trevelyan WE, Procter DP, Harrison JS (1950) Detection of sugar on paper chromatograms. Nature 166:444–445
Xu ZH, Yang LJ (1993) Transformation in Salvia chinensis. In: Bajaj YPS (ed) Biotechnology in agriculture and forestry, vol 22. Plant protoplasts and genetic Engineering III. Springer, Berlin Heidelberg New York, pp 308–313
Zhang YL, Song JK, Lu KL, Liu HL (1995a) Establishment of hairy root cultures and production of tanshinones in Salvia miltiorrhiza. Chin Meteria Med Acta 20:269–271
Zhang YL, Song JY, Zhao BH, Liu HL (1995b) Crown gall tissue culture and production of tanshinone in Salvia miltiorrhiza. Chin J Biotechnol 11:150–152
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Hu, Z.B., Liu, D., Alfermann, A.W. (1999). Genetic Transformation of Salvia miltiorrhiza . In: Bajaj, Y.P.S. (eds) Transgenic Medicinal Plants. Biotechnology in Agriculture and Forestry, vol 45. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58439-8_18
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DOI: https://doi.org/10.1007/978-3-642-58439-8_18
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