Skip to main content

The Safety Aspects of Systemic and Topical Antifungal Agents Used in the Management of Onychomycosis

  • Conference paper

Abstract

When deciding upon the optimal antifungal agent for treating onychomycosis, the safety profile of the available agents is an important consideration. The topical antifungal agents have adverse events that are localized to the application site, and these are generally not as significant as the adverse effects that may occur with oral agents. The drug of choice is the most cost-effective antimycotic with an acceptable adverse-events profile.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gupta AK, Sauder DN, Shear NH (1994) Antifungal agents: an overview. Part I. J Am Acad Dermatol 30:677–698

    Article  PubMed  CAS  Google Scholar 

  2. Sherertz EF (1990) Are laboratory studies necessary for griseofulvin therapy? J Am Acad Dermatol 22:1103

    Article  PubMed  CAS  Google Scholar 

  3. Jones HE (1982) Ketoconazole. Arch Dermatol 118:217–219

    Article  PubMed  CAS  Google Scholar 

  4. Knight TE, Shikuma CY, Knight J (1991) Ketoconazole-induced fulminant hepatitis necessitating liver transplantation. J Am Acad Dermatol 25:398–400

    Article  PubMed  CAS  Google Scholar 

  5. Gupta AK, Sauder DN, Shear NH (1994) Antifungal agents: an overview. Part II. J Am Acad Dermatol 30:911–933

    Article  PubMed  CAS  Google Scholar 

  6. Pittrof F, Gerhards J, Erni W et al (1992) Loceryl nail lacquer—realization of a new galenical approach to onychomycosis therapy. Clin Exp Dermatol 17[Suppl l]:26–28

    Article  PubMed  Google Scholar 

  7. Baran R (1993) Amorolfine nail lacquer: a new transungual delivery system for nail mycoses. JAMA [Southeast Asia Supplement] 9:5–6

    Google Scholar 

  8. Rigopoulos D, Katsambas A, Antoniou C et al (1996) Discoloration of the nail plate due to the misuse of amorolfine 5% nail lacquer. Acta Derm Venereol 76:83–84

    PubMed  CAS  Google Scholar 

  9. Reinel D (1992) Topical treatment of onychomycosis with amorolfine 5% nail lacquer: comparative efficacy and tolerability of once and twice weekly use. Dermatology 184[Suppl l]:21–24

    Article  PubMed  Google Scholar 

  10. Salasche SJ (1990) Surgery. In: Scher RK, Daniel CR III (eds) Nails: therapy, diagnosis, surgery. Saunders, Philadelphia, pp 258–280

    Google Scholar 

  11. Haneke E, Baran R (1994) Nail surgery and traumatic abnormalities. In: Baran R, Dawber RPR (eds) Diseases of the nails and their management, 2nd edn. Blackwell Science Publications, Oxford, pp 345–416

    Google Scholar 

  12. Baran R, Hay RJ (1985) Partial surgical avulsion of the nail in onychomycosis. Clin Exp Dermatol 10:413–418

    Article  PubMed  CAS  Google Scholar 

  13. Cohen PR, Scher RK (1994) Topical and surgical treatment of onychomycosis. J Am Acad Dermatol 31:S74–77

    Article  PubMed  CAS  Google Scholar 

  14. Farber EM, South DA (1994) Urea ointment in the nonsurgical avulsion of nail dystrophies. Cutis 22:689–692

    Google Scholar 

  15. South DA, Farber EM (1980) Urea ointment in the nonsurgical avulsion of nail dystrophies—a reappraisal. Cutis 25:609–612

    PubMed  CAS  Google Scholar 

  16. Buselmeier TJ (1980) Combination urea and salicylic acid ointment nail avulsion in nondystrophic nails: a follow-up observation. Cutis 25:397–405

    PubMed  CAS  Google Scholar 

  17. Hay RJ, Roberts DT, Doherty VR et al (1988) The topical treatment of onychomycosis using a new combined urea/imidazole preparation. Clin Exp Dermatol 13:164–167

    Article  PubMed  CAS  Google Scholar 

  18. Bonifaz A, Guzman A, Garcia C et al (1995) Efficacy and safety of bifonazole urea in the two-phase treatment of onychomycosis. Int J Dermatol 34:500–501

    Article  PubMed  CAS  Google Scholar 

  19. Fritsch H (1992) Ultrastructural changes in onychomycosis during the treatment with bifonazole/urea ointment. Dermatology 185:32–36

    Article  PubMed  CAS  Google Scholar 

  20. Ishii M, Hamada T, Asai Y (1983) Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment. Dermatologica 167:273–279

    Article  PubMed  CAS  Google Scholar 

  21. White MI, Clayton YM (1982) The treatment of fungus and yeast infections of nails by the method of chemical removal. Clin Exp Dermatol 7:273–276

    Article  PubMed  CAS  Google Scholar 

  22. Rollman O, Johansson S (1987) Hendersonula toruloidea infection: successful response of onychomycosis to nail avulsion and topical ciclopiroxolamine. Acta Derm Venereol 67:506–510

    PubMed  CAS  Google Scholar 

  23. Leshin B, Whitaker DC (1988) Carbon dioxide laser matricectomy. J Dermatol Surg Oncol 14:608–611

    PubMed  CAS  Google Scholar 

  24. Scher RK (1981) Surgical avulsion of nail plates by a proximal to distal technique. J Dermatol Surg Oncol 7:296–297

    PubMed  CAS  Google Scholar 

  25. Rothermel E, Apfelberg DB (1987) Carbon dioxide laser use for certain diseases of the toenails. Clin Podiatr Med Surg 4:809–821

    PubMed  CAS  Google Scholar 

  26. Geronemus RG (1992) Laser surgery of the nail unit. J Dermatol Surg Oncol 18:735–743

    PubMed  CAS  Google Scholar 

  27. Apfelberg DB, Rothermel E, Eidtfeldt A et al (1984) Preliminary report on use of carbon dioxide laser in podiatry. J Am Podiatr Med Assoc 74:509–513

    CAS  Google Scholar 

  28. Gupta AK, De Doncker P, Scher RK et al (1997) Itraconazole for the treatment of onychomycosis: an overview. Dermatologic Clinics 15:121–135

    Article  PubMed  CAS  Google Scholar 

  29. Shear NH, Gupta AK (1995) Terbinafme for the treatment of pedal onychomycosis: a foot closer to the promised land of cured nails? Arch Dermatol 131:937–942

    Article  PubMed  CAS  Google Scholar 

  30. Sandoz Inc. (1995) Terbinafine product monograph. Sandoz Inc., Dorval, Québec

    Google Scholar 

  31. Sandoz Inc. (1996) Terbinafine product monograph. Sandoz Inc., New Jersey, USA

    Google Scholar 

  32. Pfizer Inc. (1994) Fluconazole product monograph. Pfizer Inc., Kirkland, Québec

    Google Scholar 

  33. Hay RJ (1993) Risk/benefit ratio of modern antifungal therapy: focus on hepatic reactions. J Am Acad Dermatol 29:S50–S54

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Gupta, A.K. (1999). The Safety Aspects of Systemic and Topical Antifungal Agents Used in the Management of Onychomycosis. In: Shuster, S. (eds) Hydroxy-Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58401-5_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58401-5_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65494-0

  • Online ISBN: 978-3-642-58401-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics