Skip to main content
SpringerLink
Log in

Antipruriginosa, Lokalanästhetika, Antihidrotika und Lichtschutz

  • Chapter
Dermatologische Externatherapie

Zusammenfassung

Menthol (Abb. 15.1) gehört zur Klasse der zyklischen Terpenalkohole. Es existieren 8 Stereoisomere bzw. 4 Racemformen. Im DAB ist nur das linksdrehende (1R, 3R, 4 S)-3p-Menthanol und das racemische Menthol aus (1R, 3R, 4 S und 1 S, 3 S, 4R)-3p-Menthanol zugelassen. Menthol ist ein weißes kristallines Pulver oder eine kristallinerstarrte Schmelze. Sehr schwer löslich in Wasser, sehr gut löslich in Lipidbasen wie Vaselin oder Erdnussöl. Gut löslich auch in anderen Ölen. Den angestrebten Kühleffekt hat nur das linksdrehende Menthol und in geringerem Maß das racemische. Es wurden eine Vielzahl von Derivaten entwickelt, deren Anwendung jedoch noch nicht zur Routine geworden ist (Watson et al.1978;Eccles 1994).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 19.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 39.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 39.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Berberian BJ, Breneman DL, Drake LA, Gratton D, Raimir S, Philips S, Sulica VI, Bernstein JE (1999) The addition of topical doxepin to corticosteroid therapy: an improved treatment regimen for atopic dermatitis. Int J Dermatol 18: 145–148

    Article  Google Scholar 

  • Bernstein JE, Korman NJ, Bickers DR, Dahl MV, Millikan LE (1989) Topical capsaicin treatment of chronic postherpetic neuralgia. J Am Acad Dermatol 21: 265–270

    Article  PubMed  CAS  Google Scholar 

  • Böhler-Sommeregger K, Lindemayr H (1986) Contact sensitivity to aluminium. Contact Dermatitis 15: 278–281

    Article  PubMed  Google Scholar 

  • Brandrup F, Larsen PO (1978) Axillary hyperhidrosis: local treatment with aluminium chloride hexahydrate 25% in absolute ethanol. Acta Derm Venereol (Stockh) 58: 461–465

    CAS  Google Scholar 

  • Bromberg F, Brodin A, Ackerman B, Frank SG (1982) In vitro and in vivo studies on lidocaine formulated in an o/w cream and in a polyethylene glycol ointment. Acta Pharm Suec 19: 229–240

    Google Scholar 

  • Bromme B, Scharein E, Darsow U, Ring J (1995) Effects of menthol and cold on histamine-induced itch and skin reactions in man. Neurosci Lett 187: 157–160

    Article  Google Scholar 

  • Budde J, Stary A, Reiteke U (1989) Kontaktallergie vom Soforttyp auf topische Anwendung von Lidocain. Dermatosen 37: 181–182

    CAS  Google Scholar 

  • Buhles N, Richter R (1989) Balneologische Therapie der Neurodermitis mit polidocanolhaltigem Badezusatz - Klinische Erfahrungen und percutane Resorption. Akt Dermatol 15: 249–253

    Google Scholar 

  • Burtin P, Ito S (1995) Clinical pharmacology and toxicology of EMLA. In: Koren G (ed). Eutectic mixture of local anesthetics (EMLA - a breakthrough in skin anesthesia). Marcel Dekker, New York Basel Hong Kong, pp 17–36

    Google Scholar 

  • Carlfors J, Blute I, Schmidt V (1991) Lidocaine in microemulsion - a dermal delivery system. J Dispers Sci Tech 12: 467–482

    Article  CAS  Google Scholar 

  • Cecarini JP (1996) Lichtschutz, Sonnenschutz: Von der UV-Absorption bis zu den Lichtschutzfaktoren. Akt Dermatol 22: 20–24

    Google Scholar 

  • Cullen SI (1975) Topical methenamine therapy for hyperhidrosis. Arch Dermatol 111: 1158–1160

    Article  PubMed  CAS  Google Scholar 

  • Deplazes C, Möli F, Panizzon R (1997) Dermatologische Magistralrezepturen in der Schweiz, 2. Aufl. Privatdruck Winterthur

    Google Scholar 

  • Diffey BL, Stokes RP, Forestier S, Mazilier C, Richard A, Rougier A (1998) Suncare product photostability: a key parameter for a more realistic in vitro efficacy evaluation. Part 1: in vitro efficacy assessment. In: Rougier A, Schaefer H (eds). Protection of the skin against ultraviolet radiations. John Libbeys Eurotext, Paris, pp 137–142

    Google Scholar 

  • Drake LA, Cohen L, Gillies R, Flood JG, Riordan AT, Phillips SB, Stiller MJ (1999) Pharmacokinetics of doxepin in subjects with pruritic atopic dermatitis. J Am Acad Dermatol 41: 209–214

    Article  PubMed  CAS  Google Scholar 

  • Dromgoole SH, Maibach HI (1990) Sunscreening agent intolerance: contact and photocontact sensitization and contact urticaria. J Am Acad Dermatol 22: 1068–1078

    Article  PubMed  CAS  Google Scholar 

  • Eccles R (1994) Menthol and related cooling compounds. J Pharm Pharmacol 46: 618–630

    Article  PubMed  CAS  Google Scholar 

  • Ellis CN, Berberian B, Sulica VI, Dodd AW, Jarratt MT, Katz HI, Prawer St, Krueger G, Rex IH, Wolff JE (1993) A double-blind evaluation of topical capsaicin in pruritic psoriasis. J Am Acad Dermatol 29: 438–442

    Article  CAS  Google Scholar 

  • Engberg G, Danielson K, Henneberg S, Nilsson A (1987) Plasma concentrations of prilocaine and lidocaine and methaemoglobin formation in infants after epicutaneous application of a 5 lidocaine-prilocaine cream (EMLA). Acta Anaesthesiol Scand 31: 624–628

    Article  PubMed  CAS  Google Scholar 

  • Finkel P (1999a) Formulierung kosmetischer Sonnenschutzmittel. Parf Kosm 80: 10–16

    CAS  Google Scholar 

  • Finkel P (1999b) Sense and nonsense of sun protection factors. SÖFW J 125: 12–17

    Google Scholar 

  • Fourtanier A, Cohen C, Guéniche A, Ley R, Moyal D, Seité S (1998) Which kind of protection a broad absorption UVA sunscreen provides? In: Rougier A, Schaefer H (eds). Protection of the skin against ultraviolet radiations. John Libbeys Eurotext, Paris, pp 149–157

    Google Scholar 

  • Gabard B, Bieli E, Lüdi S, Schwab S, Treffel P (1998) Sonnenschutzmittel: Kosmetisches Vehikel und Lichtschutz. Kosm Med 18: 352–355

    Google Scholar 

  • Gabard B, Bieli E, Lüdi S (1999) Moderne Konzepte im Sonnenschutz. Swiss Pharma 21: 13–19

    Google Scholar 

  • Garbe C, Reimann H, Sander-Bähr C (1996) Rationelle dermatologische Rezeptur. Thieme Verlag-Govi Verlag, Stuttgart, S 157

    Google Scholar 

  • Gasparro FP, Mitchnick M, Nash JF (1998) A review of sunscreen safety and efficacy. Photochem Photobiol 68: 243–256

    Article  PubMed  CAS  Google Scholar 

  • Goh CL (1990) Aluminium chloride hexahydrate versus palmar hyperhidrosis-evaporimeter assessment. Int J Dermatol 29: 368–370

    Article  PubMed  CAS  Google Scholar 

  • Gupta AK, Koren G, Shear NH (1998) A double-blind, randomized, placebo-controlled trial of eutectic lidocaine/prilocaine cream 5% (EMLA) for analgesia prior to cryotherapy of warts in children and adults. Pediatr Dermatol 15: 129–133

    Article  PubMed  CAS  Google Scholar 

  • Hagan DB, Leng FJ, Smith PM, Snow M, Watson A (1997) Antiperspirant compositions based on titanium salts. Int J Cosm Sci 19: 271–280

    Article  CAS  Google Scholar 

  • Halpern SM, Ahluwalia A, Makunura CN, Jordan S (1996) Investigation of notalgia paraesthetica using laser doppler velocimetry and immunohistochemistry before and after treatment with topical capsaicin. J Eur Acad Dermatol Venereol 7: 228–234

    Article  Google Scholar 

  • Hauss H, Proppe A, Matthies C (1993) Vergleichende Untersuchungen zur Behandlung von trockener, juckender Haut mit einer Zubereitung aus Harnstoff und Polidocanol sowie einer Linolsäurehaltigen Fettcreme. Dermatosen 41: 184–188

    Google Scholar 

  • Hayakawa R, Yamamura M, Sugiura M (1996) Contact dermatitis from 1-menthol. Cosm Toil 111: 28–29

    Google Scholar 

  • Hölzle E (1999) Antiperspirants In: Gabard B, Elsner P, Surber C, Treffel P (eds). Dermatopharmacology of topical preparations - A product-development orientated approach. Springer, Berlin Heidelberg New York, pp 401–416

    Google Scholar 

  • Hölzle E, Braun-Falco O (1984) Structural changes in axillary eccrine glands following long-term treatment with aluminium chloride hexahydrate solution. Br J Dermatol 110: 399–403

    Article  PubMed  Google Scholar 

  • Hölzle E, Kligman AM (1979) Factors influencing the anti-perspirant action of aluminium salts. J Soc Cosm Chem 30: 357–367

    Google Scholar 

  • Holst RG, Kristofferson A (1998) Lidocaine-prilocaine cream (EMLA Cream) as a topical anaesthetic for the cleansing of leg ulcers - the effect of length of application time. Eur J Dermatol 8: 245–247

    PubMed  CAS  Google Scholar 

  • van den Hove J, Decoroix J, Tennstedt D, Lachapelle JM (1994) Allergic contact dermatitis from prilocaine, one of the local anesthetics in EMLA cream. Contact Dermatitis 30: 239

    Article  PubMed  Google Scholar 

  • Humphreys FS, Shuster S (1987) The effect of topical dimethindene maleate on wheal reaction. Br J Clin Pharmacol 23: 234–236

    Article  PubMed  CAS  Google Scholar 

  • Jakobson B, Nilsson A (1985) Methaemoglobinemia associated with a prilocaine-lidocaine cream and trimetoprim sulphamethoxazole. A case report. Acta Anaesthesiol Scand 29: 453–455

    Article  CAS  Google Scholar 

  • van Kann HJM, Egberts ACG, Rijnvos WPM, Pelkwijk NJT, Lenderink AW (1997) Tetracaine versus lidocaine-prilocaine for preventing venipuncture-induced pain in children. Am J Health Syst Pharm 54:388–392

    Google Scholar 

  • Kindl G (1998) Kennzeichnung von Sonnenschutzmitteln. Apoth J 20: 152–158

    Google Scholar 

  • Korting HC (1995) Dermatotherapie. Springer, Berlin Heidelberg

    Book  Google Scholar 

  • Krogstad AL, Löhnroth P, Larson G, Wallin BG (1999) Capsaicin treatment induces histamine release and perfusion changes in psoriatic skin. Br J Dermatol 141: 87–93

    Article  PubMed  CAS  Google Scholar 

  • Lademann J, Weigmann HJ, Rickmeyer C, Barthelmes H, Schaefer H, Müller G, Sterr W (1999) Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol Appl Skin Physiol 12: 247–256

    Article  PubMed  CAS  Google Scholar 

  • Leopold CS, Maibach HI (1999) Percutaneous penetration of local anesthetic bases: pharmacodynamic measurements. J Invest Dermatol 113: 304–307

    Article  PubMed  CAS  Google Scholar 

  • Lie RL, Vermeer BJ, Edelbroek PM (1990) Severe lidocaine intoxication by cutaneous absorption. J Am Acad Dermatol 23: 1026–1028

    Article  PubMed  CAS  Google Scholar 

  • Lok C, Paul C, Amblard P, Bessis D, Debure C, Faivre B, Guillot B, Ortonne JP (1999) EMLA cream as a topical anesthetic for the repeated mechanical debridement of venous leg ulcers: a double-blind, placebo-controlled study. J Am Acad Dermatol 4o: 208–213

    Article  Google Scholar 

  • Lotti R, Teofoli P, Tsampau D (1994) Treatment of aquagenic pruritus with topical capsaicin cream. J Am Acad Dermatol 30: 232–235

    Article  PubMed  CAS  Google Scholar 

  • Matsui D (1995) Pharmacology of local anesthetics. In: Koren G (ed). Eutectic mixture of local anesthetics (EMLA - a breakthrough in skin anesthesia). Marcel Dekker, New York Basel Hong Kong, pp 1–16

    Google Scholar 

  • McMahon S, Lewin G, Bloom SR (1991) The consequences of long-term topical capsaicin application in the rat. Pain 44: 301–310

    Article  Google Scholar 

  • Milankovté R, Vuleta G, Stupar M, Vocimé-Milankovné N (1986) Comparative evaluation of antiperspirative activity of mixtures containing methenamine and aluminum sulfate. Arh Farm 36: 283–286

    Google Scholar 

  • Müller-Goymann CC, Bennar C, Grünfeld J (1998) Penetration von partikulären UV-Filtern in die Haut. Parf Kosm 79: 24–26

    Google Scholar 

  • Murphy GM (1999) Sunblocks: mechanisms of action. Photodermatol Photoimmunol Photomed 15: 34–36

    Article  PubMed  CAS  Google Scholar 

  • Nagarsenker MD, Joshi AA (1997) Preparation, characterization, and evaluation of liposomal dispersions of lidocaine. Drug Dev Ind Pharm 23: 1159–1165

    Article  CAS  Google Scholar 

  • Pathak MA (1996) Sunscreens: progress and perspectives on photoprotection of human skin against UVB and UVA radiation. J Dermatol 23: 783–800

    PubMed  CAS  Google Scholar 

  • Puig L, Alegre M, Moragas JM (1995) Treatment of meralgia paraesthetica with topical capsaicin. Dermatology 191: 73–74

    Article  PubMed  CAS  Google Scholar 

  • Puschmann M (1992) Experimentelle Untersuchungsergebnisse zur Juckreizlinderung, zur Hautfettung und zur Hautverträglichkeit einer Harnstoff-und Polidocanol-haltigen Zubereitung. Akt Dermatol 18: 224–228

    Google Scholar 

  • Quatrale RP, Waldman AH, Rogers JG, Felger CB (1981) The mechanism of antiperspirant action by aluminum salts. 1. The effect of cellophane tape stripping on aluminium salt inhibited eccrine sweat glands. J Soc Cosm Chem 32: 67–73

    CAS  Google Scholar 

  • Quatrale RP, Thomas EL, Birnbaum JE (1985) The site of antiperspirant action by aluminium salts in the eccrine sweat glands of the axilla. J Soc Cosm Chem 36: 435–440

    CAS  Google Scholar 

  • Raab W (1998) Ultraviolettstrahlung A. Bewährtes - Neues - Schutz. Apoth J 20: 160–163

    Google Scholar 

  • Rains C, Bryson HM (1995) Topical capsaicin - a review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy and osteoarthritis.Drugs Aging 7: 317–328

    Article  PubMed  CAS  Google Scholar 

  • Ramping E, Oberhauser V, Nunzi E (1978) Beurteilung der lokalen Antihistaminwirkung von Dimetindenmaleat mit Hilfe einer quantitativen Methode. Dermatologica 157: 105–109

    Article  Google Scholar 

  • Reimann S, Metze D (1995) Topische Capsaicin Therapie bei Lichen simplex chronicus und Prurigo nodularis. Z Hautkr 70: 586–588

    Google Scholar 

  • Reimann S, Luger Th, Metze D (2000) Topische Anwendung von Capsaicin in der Dermatologie zur Therapie von Juckreiz und Schmerz. Hautarzt 51: 164–172

    Article  PubMed  CAS  Google Scholar 

  • Ring J, Fröhlich HH (1985) Wirkstoffe in der dermatologischen Therapie, 2. Aufl. Springer, Berlin Heidelberg

    Book  Google Scholar 

  • Riopelle J, Lopez-Anaya A, Cork RC, Heitler D, Eyrich J, Dunston A, Riopelle AJ, Johnson W, Ragan A, Naraghi M (1994) Treatment of cutaneous pain of acute herpes zoster with 9 lidocaine (base) in petrolatum/paraffin ointment. J Am Acad Dermatol 30: 757–767

    Article  PubMed  CAS  Google Scholar 

  • Rosdahl I, Edmar B, Gisslén H, Nordin P, Lillieborg S (1988) Curettage of molluscum contagio-sum in children: analgesia by topical application of a lidocaine/prilocaine cream (EMLA). Acta Derm Venereol (Stockh) 68: 149–153

    CAS  Google Scholar 

  • Rougier A (1998) Are UVA rays dangerous? In: Rougier A, Schaefer H (eds). Protection of the skin against ultraviolet radiations. John Libbeys Eurotext, Paris, pp 1–9

    Google Scholar 

  • Rowbotham MC, Davies PS, Verkempinck C, Galer BS (1996) Lidocaine patch: double-blind controlled study of a new treatment method for post-herpetic neuralgia. Pain 65: 39–44

    Article  PubMed  CAS  Google Scholar 

  • Rumsfield JA, West DP (1991) Topical capsaicin in dermatologic and peripheral pain disorders. DICP Ann Pharmacother 25: 381–387

    CAS  Google Scholar 

  • Schaefer H, Moyal D, Fourtanier A (1998) Recent advances in sun protection In: Rougier A, Schaefer H (eds). Protection of the skin against ultraviolet radiations. John Libbeys Eurotext, Paris, pp 119–129

    Google Scholar 

  • Schäfer R, Schäfer W (1982) Die percutane Resorption verschiedener Terpene - Menthol, Campher, Limonen, Isobornylacetat, aPinen - aus Badezusätzen. Arzneimittelforschung 32: 56–58

    PubMed  Google Scholar 

  • Schauder S (1990) Literaturübersicht über Unverträglichkeitsreaktionen auf lichtfilterhaltige Produkte von 1947–1989. Z Hautkr 65: 982–998

    PubMed  CAS  Google Scholar 

  • Singh P, Roberts MS (1994) Dermal and underlaying tissue pharmacokinetics of lidocaine after topical application. J Pharm Sci 83: 774–781

    Article  PubMed  CAS  Google Scholar 

  • Stokes R (1999) Project sunscreen protection In: Gabard B, Elsner P, Surber C, Treffel P (eds). Dermatopharmacology of topical preparations - A product-development orientated approach. Springer, Berlin Heidelberg New York, pp 365–382

    Google Scholar 

  • Susak Z, Minkov R, Isakov E (1996) The use of methenamine as an antiperspirant for amputees. Prosthet Orthot Int 20: 172–175

    PubMed  CAS  Google Scholar 

  • Tandan R, Lewis G, Fries T (1990) Safety of topical capsaicin in diabetic neuropathy. Neurology 40 Suppl 1: 160

    Google Scholar 

  • Timper R (1966) Zur Behandlung des Schweißfußes in der truppenärztlichen Praxis. Wehrmed Monatsschr 10: 271–272

    Google Scholar 

  • Treffel P, Gabard B (1996) Skin penetration and sun protection factor of ultra-violet filters from two vehicles. Pharm Res 13: 770–774

    Article  PubMed  CAS  Google Scholar 

  • Tronnier H (1998) Neues zum Lichtschutz und der Bewertung von Lichtschutzmitteln. SÖFW J 124: 472–476

    CAS  Google Scholar 

  • Vieluf D, Matthies C, Ring J (1992) Trockene juckende Haut - ihre Behandlung mit einer neuen Polidocanol-Harnstoff-Zubereitung. Z Hautkr 67: 816–821

    Google Scholar 

  • Wagner G, Mensing H (1989) Erfahrungen mit der percutanen Anästhesie bei Verwendung einer Lidocain-Prilocain Creme (EMLA Creme 5%). Z Hautkr 64: 688–693

    PubMed  CAS  Google Scholar 

  • Wallengren J, Klinker M (1995) Successful treatment of notalgia paresthetica with topical capsaicin: vehicle - controlled, double blind, crossover study. J Am Acad Dermatol 32: 287–289

    Article  PubMed  CAS  Google Scholar 

  • Watson CPN, Tyler KL, Bickers DR, Millikan LE, Smith S, Coleman E (1993) A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. Clin Ther 15: 510–526

    PubMed  CAS  Google Scholar 

  • Watson HR, Hems R, Rowsell DG, Spring DJ (1978) New compounds with the menthol cooling effect. J Soc Cosm Chem 29: 185–200

    CAS  Google Scholar 

  • Weisshaar E, Heyer G, Forster C, Handwerker HO (1998) Effect of topical capsaicin on the cutaneous reactions and itching to histamine in atopic eczema compared to healthy skin. Arch Dermatol Res 290: 306–311

    Article  PubMed  CAS  Google Scholar 

  • Williams SA, Mongomery I, McEwan, Jenkinson E, Elder HY, Wilson SM, Sutton AM (1987) Effects of topically - applied antiperspirant on sweat gland function. Br J Dermatol 117: 717–726

    Google Scholar 

  • Wokalek K (1992) Antipruritika. In: Niedner R, Ziegenmeyer J (Hrsg). Dermatika. Therapeu-tischer Einsatz, Pharmakologie und Pharmazie. Wiss Verlagsgesellschaft, Stuttgart, S 148–155

    Google Scholar 

  • Yosipovitch G, Szolar C, Hui XY (1996) Effect of topically applied menthol on thermal, pain anditch sensations and biophysical properties of the skin. Arch Dermatol Res 288: 145–148

    Article  Google Scholar 

  • Záhenskÿ J, Rovenskÿ J (1972) A comparison of the effectiveness of several external antiperspirants. J Soc Cosm Chem 23: 775–789

    Google Scholar 

Download references

Authors
  1. M. Gloor
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gloor, M. (2000). Antipruriginosa, Lokalanästhetika, Antihidrotika und Lichtschutz. In: Dermatologische Externatherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58308-7_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58308-7_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63533-5

  • Online ISBN: 978-3-642-58308-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation