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Antimikrobiell wirksame Substanzen (exklusiv Antibiotika)

  • Chapter
Dermatologische Externatherapie

Zusammenfassung

Im Folgenden wird zu den wichtigsten Antiseptika Stellung genommen, soweit sie nicht in anderen Kapiteln besprochen werden (Benzoylperoxid und Azelainsäure s. Kap. 9, Zinkacetat s. Abschn.11.4). Negativ monographierte und obsolete Wirkstoffe (z. B. Phenol, Hexachlorophen, Quecksilberderivate oder Cadmiumsulfid) bleiben unberücksichtigt.

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Literatur

  • Arrese JE, Piérard-Franchimont C, De Doncker P, Heremans A, Cauwenbergh G, Piérard GE (1996) Effect of ketoconazole-medicated shampoos on squamomerty and malassezia ovalis load in pityriasis capitis. Cutis 58: 235–237

    PubMed  CAS  Google Scholar 

  • Aursnes J (1981) Cochlear damage from chlorhexidine in guinea pigs. Acta Otolaryngol 92: 259–271

    CAS  Google Scholar 

  • Balogh D, Bauer M, Riccabona G (1985) The influence of povidone-iodine treatment on thyroid hormones in severne burns. J Hosp Infect 6: 147–153

    Article  PubMed  Google Scholar 

  • Bergman H (1988) Is podophyllin a safe drug to use and can it be used in pregnancy? Arch Dermatol 124: 1718–1720

    Article  Google Scholar 

  • Bertram B (1992) Toxikologische Bewertung einiger in der Dermatologie verwendeter Wirkstoffe. Dermatosen 40: 51-55

    CAS  Google Scholar 

  • Beutner K R, Tyring SK, Trofatter KF Jr, Douglas JM Jr, Spruance S, Owens ML, Fox TL, Hougham AJ, Schmitt KA (1998a) Imiquimod, a patient-applied immune-response modifier for treatment of external genital warts. Antimicrob Agents Chemother 42: 789–794

    PubMed  CAS  Google Scholar 

  • Beutner K R, Spruance SL, Hougham AJ, Fox TL, Owens ML, Douglas JM (1998b) Treatment of genital warts with an immune-response modifier (imiquimod). J Am Acad Dermatol 38: 230–239

    Article  PubMed  CAS  Google Scholar 

  • Bhargava HN, Leonard PA (1996) Triclosan: applications and safety. Am J Infect Control 24: 209–218

    Article  PubMed  CAS  Google Scholar 

  • Black JG, Howes D (1975) Percutaneous absorption of triclosan from toilet preparations. J Soc Cosm Chem 26: 205–215

    CAS  Google Scholar 

  • Bogash RC (1956) Polyvinylpyrrolidone iodine, a three year observation of a new topical germicide. Bull Am Soc Hosp Pharm 13: 226–229

    Google Scholar 

  • Burton JL, Holden CA (1998) Eczema, lichenification and prurigo. In: Champion RH, Burton JL, Burns DA, Breathnach SM (eds) Textbook of dermatology, voll, Blackwell Science, pp 629–680

    Google Scholar 

  • Cauwenbergh G, De Doncker P, Schrooten P, Degreef H (1986) Treatment of dandruff with a 2% ketoconazole scalp gel. A double-blind placebo-controlled study. Clin Trials 25: 541–542

    CAS  Google Scholar 

  • Corey L, Nahmias AJ, Guinan ME, Benedetti J, Critschlow LW, Holmes KK (1982) A trial of topical acyclovir in genital herpes simplex virus infections New Engl J Med. 306: 1313–1319

    CAS  Google Scholar 

  • Danby FW, Maddin WS, Margersson LJ, Rosenthal D (1993) A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5 To shampoo in the treatment of moderate to severe dandruff. J Am Acad Dermatol 29: 1008–1012

    Article  PubMed  CAS  Google Scholar 

  • Degen PH, Moppert J, Schmid K, Weirich EG (1979) Percutaneous absorption of clioquinol (Vio-form). Dermatologica 159: 295–301

    Article  PubMed  CAS  Google Scholar 

  • Faergemann J, Jones TC, Hettler D, Loria Y (1996) Pityrosporum ovale (Malassezia furfur) as the causative agent of seborrhoic dermatitis: new treatment options. Br J Dermatol 134 Suppl 46: 12–15

    Article  Google Scholar 

  • Fiddian AP, Yeo JM, Stubbings R, Dean D (1983) Successfull treatment of herpes labialis with topical acyclovir. BMJ 286: 1699–1701

    Article  PubMed  CAS  Google Scholar 

  • Fluhr JW, Gloor M (1997) Alternativvorschläge für die obsoleten Rezepturen Solutio Castellani und Fabry Spiritus. Akt Dermatol 23: 252–256

    Google Scholar 

  • Franz TJ, Lehmann PA, Franz SF, Guin JD (1996) Comparative percutaneous absorption of lindan and permethrin. Arch Dermatol 132: 901–905

    Article  PubMed  CAS  Google Scholar 

  • Gallenkemper G, Rabe E, Bauer R (1998) Contact sentization in chronic venous insufficiency: modern wound dressings. Contact Dermatitis 38: 274–278

    Article  PubMed  CAS  Google Scholar 

  • Gehring W, Glutsch J, Schönian U, Gehse M, Gloor M (1990) Vergleichende Untersuchung über die Wirkung verschiedener Antiseptika und der Ozonbegasung auf Ulcus cruris-übliche Keime. Z Hautkr 65: 746–750

    PubMed  CAS  Google Scholar 

  • Gehring W, Forssman Th, Jost G, Gloor M (1996) Die keimreduzierende Wirkung von Erythromycin und Triclosan bei atopischen Dermatitis. Akt Dermatol 22: 28–31

    Google Scholar 

  • Gehse M, Küster S, Gloor M (1987) Uber die effektive Hornschichthemmtiefe von Ciclopiroxicam und Naftifin in Abhängigkeit von der galenischen Zubereitung. Mykosen 30: 322–325

    Article  PubMed  CAS  Google Scholar 

  • Gerven F, Odds FC (1995) The anti-Malassezia furfur activity in vitro and in experimental dermatitis of six imidazole antifungal agents: bifonazole, clotrimazole, flutrimazole, ketoconazole, miconazole and sertaconazole. Mycosis 38: 389-393

    Article  Google Scholar 

  • Glezerman M, Cohen V, Movshovitz M, Shomam J, Lunenfeld E, Sarov I, Doerner T, Revel M (1988) Placebokontrollierte Studie über die topische Interferon-Anwendung bei Herpes Labialis und Genitalis. Lancet (Dtsch Ausg) 2: 293–296

    Google Scholar 

  • Gloor M, Gehse M (1990) Shampooing and shampoos. In: Orfanos CE, Happle R (eds) Hair and hair diseases, Springer, Berlin Heidelberg New. York, pp 975–998

    Google Scholar 

  • Gloor M, Baldes G, Lipphardt BA, Jäger B (1978) Uber den Effekt von Selendisulfid auf Menge und Zusammensetzung der Kopfhaut-und Haarlipide. Therapiewoche 28: 3582–3588

    Google Scholar 

  • Gloor M, Mildenberger KH, Mildenberger G (1979) The effect of the bis-(2-pyridil-1-oxid)-dis-ulfide adduct with MgSO4, on the scalp and hair lipids. Arzneimittelforschung 29: 670–672

    PubMed  CAS  Google Scholar 

  • Goh CL (1989) Contact sensibility to topical antimicrobials. Contact Dermatitis 21: 46–48

    Article  PubMed  CAS  Google Scholar 

  • Goldschmidt H, Kligman AM (1968) Increased sebum secretion following selenium sulfide shampoos. Acta Derm Venereol (Stockh) 48: 489–491

    CAS  Google Scholar 

  • Grover RW (1956) Diffuse hair loss associated with selenium (selsun) sulfide shampoo. J Am Med Ass 160: 1397–1398

    Article  CAS  Google Scholar 

  • Gupta AK, Kohli Y, Faergemann J, Summerbell R (2000) In vitro susceptibility of the seven Malassezia species to ketoconazole, voriconazole, itraconazole and terbinafine. Br J Dermatol 142: 758–765

    Article  PubMed  CAS  Google Scholar 

  • Häckh G, Schwarzmüller E (1992) Codex dermatologischer Wirkstoffe. In: Niedner R, Ziegenmeyer J (Hrsg) Dermatika-Therapeutischer Einsatz, Pharmakologie und Pharmazie, Wissenschaftliche Verlagsgesellschaft, Stuttgart, S 311–473

    Google Scholar 

  • Hausen BM (1994) Lexikon der Kontaktallergene. Ecomed, Landsberg

    Google Scholar 

  • Hay RJ, Graham-Brown RAC (1997) Dandruff and seborrhoeic dermatitis: causes and management. Clin Exp Dermatol 22: 3–6

    Article  PubMed  CAS  Google Scholar 

  • Hollinger MA (1996) Toxicological aspects of topical silver pharmaceuticals. Crit Rev Toxicol 26: 255–260

    Article  PubMed  CAS  Google Scholar 

  • Hornstein OP (1985) Wichtige vorwiegend entzündliche Hautkrankheiten und ihre Therapie. In: Hornstein OP, Nürnberg E (Hrsg) Externe Therapie von Hautkrankheiten, Georg Thieme, Stuttgart New York, S 265–375

    Google Scholar 

  • John SM, Geier J (1998) Unterschenkelekzem bei chronisch-venöser Insuffizienz - Aktuelle allergologische Aspekte. Z Dermatol 184: 16–23

    Google Scholar 

  • Kawana R, Kitamura T, Nakagomi O, Matsumoto I, Arita M, Yoshihara N, Yanagi K, Yamada A, Morita O, Yoshida Y, Furuya Y, Chiba S (1997) Inactivation of human viruses by povidoneiodine in comparison with other antiseptics. Dermatology 195 Suppl 2: 29–35

    Google Scholar 

  • Kingborn CR (1985) Topical acyclovir in the treatment of recurrent herpes simplex virus infections. Scand J Infect Dis Suppl 47: 58–62

    Google Scholar 

  • Koch E (1985) Antiseptika und Antiparasitosa. In: Hornstein OP, Nürnberg E (Hrsg) Externe Therapie von Hautkrankheiten, Georg Thieme, Stuttgart New York, S 140–146

    Google Scholar 

  • Kunisada T, Yasada K, Oda S, Hara O (1997) Investigation on the efficacy of povidone-iodine against antiseptics resistant species. Dermatology 195 Suppl 2: 14–18

    Google Scholar 

  • Lanker-Klossner B, Widmer HR, Frey F (1997) No development of resistance by bacteria during hospital use of povidone-iodine. Dermatology 195 Suppl 2: 10–13

    Google Scholar 

  • Lee SM, Lee SH (1994) Generalized argyria after habitual use of AgNO3. J Dermatol 21: 50–53

    PubMed  CAS  Google Scholar 

  • Listemann H, Schölermann A, Meigel W (1993) Antimyzetische Aktivität von sulfonierten Schieferölen. Arzneimittelforschung 43: 784–788

    PubMed  CAS  Google Scholar 

  • Marks R, Pearse AD, Walker AP (1985) The effects of a shampoo containing zinc pyrithione on the control of dandruff. Br J Dermatol 112: 415–422

    Article  PubMed  CAS  Google Scholar 

  • McGinley KJ, Leyden JJ, Marples RR, Path MRC, Kigman AM (1975) Quantitative microbiology of the scalp in non-dandruff, dandruff and seborrhoeic dermatitis. J Invest Dermatol 64: 401–405

    Article  Google Scholar 

  • Melnik B (1999) Besonderheiten der Scabiestherapie: Schwangerschaft, Ivermectin, Resistenzproblem In: Plewig G, Wolff H (Hrsg) Fortschritte der praktischen Dermatologie und Venerologie 16, Springer, Berlin Heidelberg New York, S 511–517

    Google Scholar 

  • Michel D, Zäch GA (1997) Antiseptic efficacy of disinfecting solutions in suspension test in vitro against methicillin-resistant staphyloccocus aureus, Pseudomonas aeruginosa and escherichia coli in pressure sore wounds after spinal cord injury. Dermatology 195 Suppl 2: 36–41

    Article  PubMed  Google Scholar 

  • Möhlenbeck F (1970) Antibiotika, Triphenylmethanfarbstoffe und Borsäure bei zunehmender Häufigkeit von Pseudomonas aeruginosa. Z Haut Geschlkrh 45: 329–332

    Google Scholar 

  • Monographie (1988) Selen (IV)-sulfid. BAnz 40: 3135

    Google Scholar 

  • Monographie (1991) Polyvidon-Jod. BAnz 43: 3511

    Google Scholar 

  • Monographie (1993) Schwefel. BAnz 45: 845

    Google Scholar 

  • Monographie (1994) Chlorhexidin und Chlorhexidin Salze. BAnz 46: 9127–9128

    Google Scholar 

  • Müntener M, Schwarz H, Reber H (1972) Zur chirurgischen Händedesinfektion mit einem Jodophor (Betadine). Schweiz Med Wochenschr 102: 699–702

    PubMed  Google Scholar 

  • Nenoff P, Haustein UF (1994) Der Effekt anti-seborrhoischer Substanzen gegenüber Pityrosporon ovale in vitro. Hautarzt 45: 464–467

    Article  PubMed  CAS  Google Scholar 

  • Nenoff P, Haustein UF, Munzberger C (1995) In vitro activity of lithium succinate against Malassezia furfur. Dermatology 190: 48–50

    Article  PubMed  CAS  Google Scholar 

  • Niedner R (1992a) Antimykotika. In: Niedner R, Ziegenmeyer J (Hrsg) Dermatika-Therapeutischer Einsatz, Pharmakologie und Pharmazie, Wissenschaftliche Verlagsgesellschaft, Stuttgart, S 99–105

    Google Scholar 

  • Niedner R (1992b) Virustatika. In: Niedner R, Ziegenmeyer J (Hrsg) Dermatika-Therapeutischer Einsatz, Pharmakologie und Pharmazie, Wissenschaftliche Verlagsgesellschaft, Stuttgart, S 116–119

    Google Scholar 

  • Niedner R (1997) Cytotoxicity and sensitization of povidone-jodine and other frequently used anti-infective agents. Dermatology 195 Suppl 2: 89–92

    Article  PubMed  Google Scholar 

  • Niedner R, Schöpf E (1986) Inhibition of wound healing by antiseptics. Br J Dermatol 115: 41–44

    Article  PubMed  Google Scholar 

  • Paetzoldt OH (1963) Experimentelle Untersuchungen über die baktericide Wirkung des Brillantgrün auf Staphylokokken. Arch Klin Exp Dermatol 216: 446-455

    Google Scholar 

  • Paetzold OH (1980) Die in-vitro Empfindlichkeit von Candida gegenüber TriphenylmethanFarbstoffen. Z Hautkr 55: 824–833

    PubMed  CAS  Google Scholar 

  • Perrenoud D, Bircher A, Hunziker T, Suter H, Bruckner-Tuderman L, Stager J, Thürlimann W, Schmid P, Suard A, Hunziker N (1994) Frequency of sensitization to 13 common preservatives in Switzerland. Contact Dermatitis 30: 276–279

    Google Scholar 

  • Peter RU, Richarz-Barthauer U (1995) Successful treatment and prophylaxis of scalp seborrhoeic dermatitis and dandruff with 2% ketoconazole shampoo: results of a multicentre, double-blind, placebo-controlled trial. Br J Dermatol 132: 441–445

    Article  PubMed  CAS  Google Scholar 

  • Pfister-Wartha A (1992) Antiseptika. In: Niedner R, Ziegenmeyer J (Hrsg) Dermatika-Therapeutischer Einsatz, Pharmakologie und Pharmazie, Wissenschaftliche Verlagsgesellschaft, Stuttgart, S 106–115

    Google Scholar 

  • Piérard GE, Arrese JE, Piérard-Franchimont C, de Doncker P (1997) Prolonged effects of anti-dandruff shampoos - time to recurrence of malassezia ovalis colonization of skin. Int J Cosm Sci 19: 111–118

    Article  Google Scholar 

  • Ransone GJW, Scott NM, Knobloch CEC (1961) Selenium sulfide intoxication. New Engt J Med 264: 384–385

    Article  CAS  Google Scholar 

  • Sadharam JA, Bergman H (1989) Is podophyllin safe for use in pregnancy?. Arch Dermatol 125: 1000–1001

    Article  Google Scholar 

  • Schmäh) D, Bertram B (1981) Chemische Carcinogenese und ihre Bedeutung für die Krebsentstehung beim Menschen unter besonderer Berücksichtigung dermatologischer Aspekte. Dermatosen 29: 75-79

    Google Scholar 

  • Sheth RA (1983) A comparison of miconazole nitrate and selenium disulfide as anti-dandruff agents. Pharmacol Ther 22: 123–125

    CAS  Google Scholar 

  • Shindo K (1997) Antiseptic effect of povidone-iodine solution on abdominal skin during surgery and on thyroid gland related substances. Dermatology 195 Suppi 2: 78–84

    Article  Google Scholar 

  • Shuster S (1984) The aethiology of dandruff and mode of action of therapeutic agents. Br J Dermatol 111: 235–242

    Article  PubMed  CAS  Google Scholar 

  • Shuster S, Blatchford N (1988) Seborrhoic dermatitis and dandruff -a fungal disease. Royal Soc Med Services 132: 1–54

    Google Scholar 

  • Simon C, Stille W (1994) Antibiotikatherapie in Klinik und Praxis. Schattauer, Stuttgart New York

    Google Scholar 

  • Slade HB, Owens ML, Tomai MA, Miller RL (1998) Imiquimod 5% cream (Aldara). Exp Opin Invest Drugs 7: 437–449

    Article  CAS  Google Scholar 

  • Snyder FH, Buehler EV, Winek CL (1965) Safety evaluation of zink 2-pyridinethiol-1-oxide in a shampoo formulation. Toxicol Appi Pharmacol 7: 425–437

    Article  CAS  Google Scholar 

  • Spruance SL, Stewart JC, Freeman DJ (1990) Early application of topical 15% idoxuridine in dimethylsulfoxide shorthens the course of herpes simplex labialis: a multicentre placebo controlled trial. J Infect Dis 161: 191–197

    Article  PubMed  CAS  Google Scholar 

  • Spruance SL, Freeman DJ, Stewart JCB, McKeough MB, Wenerstrom LG, Krueger GG, Piepkorn MW, Stroop WG, Rowe NH (1991) The natural history of ultraviolet radiation induced herpes simplex labialis and response to therapy with peroral and topical formulations of acyclovir. J Infect Dis 163: 728–734

    Article  PubMed  CAS  Google Scholar 

  • Stohs SJ, Ezzeen FW, Anderson AK, Baldwin JN, Makoid MC (1984) Percutaneous absorption of iodochlorohydroxyquinoline in humans. J Invest Dermatol 82: 195–198

    Article  PubMed  CAS  Google Scholar 

  • Tausch I (1977) Zur Wirksamkeit einiger Antimykotika. Dermatol Monatsschr 163: 223–234

    PubMed  CAS  Google Scholar 

  • Tupker RA, Schur J, Coenraads PJ (1997) Irritancy of antiseptics tested by repeated open exposures on the human skin, evaluated by non-invasive methods. Contact Dermatitis 37: 213–217

    Article  PubMed  CAS  Google Scholar 

  • Wallhäuser W (1995) Praxis der Desinfektion. Georg Thieme, Stuttgart New York

    Google Scholar 

  • Wan AT, Convyers RA, Coombs CJ, Masterton JP (1991) Determination of silver in blood, urine and tissues of voluteers and burn patients. Clin Chem 37: 1683–1687

    PubMed  CAS  Google Scholar 

  • Wantke F, Gotz M, Jarisch R (1995) Contact dermatitis from Cloxyquin. Contact Dermatitis 32: 112–113

    Article  PubMed  CAS  Google Scholar 

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Fluhr, J. (2000). Antimikrobiell wirksame Substanzen (exklusiv Antibiotika). In: Dermatologische Externatherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58308-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-58308-7_10

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