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Stress Proteins pp 329–346Cite as

Heat Shock Proteins in Rheumatoid Arthritis

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 136))

Abstract

In view of the fundamental role of stress proteins in the maintenance of protein homeostasis, it seems likely that malfunctions associated with members of stress protein families would have pathological effects. Such effects might be minimal under normal physiological conditions, but could be exacerbated at times when other disease stimuli trigger the requirement for local alterations in stress protein function in particular afflicted cells or tissues. During infection, it can be anticipated that the requirement of stress proteins for cell viability will be equally essential both for the pathogen and for the infected host. Just as stress proteins are essential in “normal” as well as stressed cells, it is clear that changes in stress protein expression will be associated with physiologically normal events accompanying infection as well as with any subsequent pathological events. In addition to the direct role of stress proteins in cell physiology, their potential medical influence is compounded by their ability to act as potent immunogens. Responses to microbial stress proteins are a prominent feature of the immune repertoire in patients and in experimental animals, and there has been wide discussion of the possibility that recognition of conserved, self-like, epitopes on such antigens could influence infectious and other diseases. Three broad hypotheses have been put forward concerning the relevance of immunological reactivity to stress proteins:

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Authors
  1. W. van Eden
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Editors and Affiliations

  1. Department of Molecular Pathology, University College London, Cleveland Street, London, W1P 6DB, UK

    David S. Latchman M.A. Ph.D., D.Sc. (Head, Director) (Head, Director)

  2. Windeyer Institute of Medical Sciences, University College London, Cleveland Street, London, W1P 6DB, UK

    David S. Latchman M.A. Ph.D., D.Sc. (Head, Director) (Head, Director)

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© 1999 Springer-Verlag Berlin Heidelberg

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van Eden, W. (1999). Heat Shock Proteins in Rheumatoid Arthritis. In: Latchman, D.S. (eds) Stress Proteins. Handbook of Experimental Pharmacology, vol 136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58259-2_15

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  • DOI: https://doi.org/10.1007/978-3-642-58259-2_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63519-9

  • Online ISBN: 978-3-642-58259-2

  • eBook Packages: Springer Book Archive

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