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The Cellular Stress Gene Response in Brain

  • Chapter
Stress Proteins

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 136))

Abstract

Considerable advances in the molecular biology of the heat shock response and the role of heat shock proteins (hsps) in repair and protective mechanisms have been made using mammalian cells grown in tissue culture (Morimoto 1993; Morimoto et al. 1994; see also Chap. 3, this volume). Recently, an increasing amount of work has been carried out on intact thermoregulating animals. As will be shown in this article, the heat shock response is physiologi cally relevant since heat shock genes are turned on in the mammalian nervous system following stress treatments such as fever-like temperature, focal cerebral ischemia and subarachnoid hemorrhage. The brain is a complex structure composed of many cell types. As will become apparent, neuronal and glial cell types exhibit differences in constitutive expression of hsps and the type of brain cell that activates the heat shock response in vivo depends on the nature and the severity of the stress.

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  1. I. R. Brown
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  2. F. R. Sharp
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Editors and Affiliations

  1. Department of Molecular Pathology, University College London, Cleveland Street, London, W1P 6DB, UK

    David S. Latchman M.A. Ph.D., D.Sc. (Head, Director) (Head, Director)

  2. Windeyer Institute of Medical Sciences, University College London, Cleveland Street, London, W1P 6DB, UK

    David S. Latchman M.A. Ph.D., D.Sc. (Head, Director) (Head, Director)

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Brown, I.R., Sharp, F.R. (1999). The Cellular Stress Gene Response in Brain. In: Latchman, D.S. (eds) Stress Proteins. Handbook of Experimental Pharmacology, vol 136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58259-2_11

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