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Heart Failure Mechanisms and Management pp 15–20Cite as

Beta-Adrenoceptors in Heart Failure: A Mechanism or a cAMP Follower?

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Abstract

In the myocardium of many patients with symptoms of heart failure there is a decrease in beta-adrenoceptor number, accompanied by a reduction in responsiveness to beta-agonists [3,5,8,10,16]. The hypothesis that this results simply from exposure to high circulating catecholamines is in dispute. The role of beta-adrenoceptor desensitisation in the progression of heart failure and the therapeutic implications are the subject of considerable debate.

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Authors
  1. S. E. Harding
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  2. P. A. Poole-Wilson
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Editor information

Editors and Affiliations

  1. Department of Cardiology, Lady Davis Carmel Hospital, 34362, Haifa, Israel

    Basil S. Lewis MD (Director) (Director)

  2. University of California, Los Angeles, USA

    Asher Kimchi MD (Assistant Clinical Professor of Medicine, Attending Physician) (Assistant Clinical Professor of Medicine, Attending Physician)

  3. Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA

    Asher Kimchi MD (Assistant Clinical Professor of Medicine, Attending Physician) (Assistant Clinical Professor of Medicine, Attending Physician)

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© 1991 Springer-Verlag Berlin Heidelberg

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Harding, S.E., Poole-Wilson, P.A. (1991). Beta-Adrenoceptors in Heart Failure: A Mechanism or a cAMP Follower?. In: Lewis, B.S., Kimchi, A. (eds) Heart Failure Mechanisms and Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58231-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-58231-8_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63509-0

  • Online ISBN: 978-3-642-58231-8

  • eBook Packages: Springer Book Archive

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