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Autonomic Receptor Function in Congestive Heart Failure

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Heart Failure Mechanisms and Management

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Abstract

The major determinants of cardiac output (preload, myocardial contractility, afterload and heart rate) may all be modulated by the sympathetic nervous system. This has led to the notion, supported by much good data, that abnormalities in sympathetic neural and receptor function might contribute to the development or maintenance of cardiac dysfunction in patients with congestive heart failure. Most of the studies have been based on measurements of plasma or tissue catecholamine concentrations, or on observations of the effects of altering the sympathetic status in humans or other animals by neurophysiological or pharmacological means.

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References

  1. Ahlquist RP (1948) A study of adrenotropic receptors. Am J Physiol 153: 586–600

    PubMed  CAS  Google Scholar 

  2. Berthelson S, Pettinger WA (1977) A functional basis for classification of alpha-adrenergic receptors. Life Sci 21: 596–606

    Google Scholar 

  3. Hoffman BB, Lefkowitz RJ (1980) Radioligand binding studies of adrenergic receptors: new insights into molecular and physiological regulation. Ann Rev Pharmacol Toxicol 20: 581–608

    Article  CAS  Google Scholar 

  4. Motulsky HJ, Insel PA (1982) Adrenergic receptors in man. N Engl J Med 307: 18–29

    Article  PubMed  CAS  Google Scholar 

  5. Stiles GL, Taylor S, Lefkowitz RJ (1983) Human cardiac beta-adrenergic receptors: subtype heterogenicity delineated by direct ligand binding. Life Sci 33: 467–473

    Article  PubMed  CAS  Google Scholar 

  6. Hedberg A, Minnerman KP, Molinoff PB (1980) Differential distribution of beta-1 and beta-2 adrenergic receptors in cat and guinea-pig heart. J Pharmacol Exp Ther 212: 503–508

    PubMed  CAS  Google Scholar 

  7. Hoffman BB, Lefkowitz RJ (1980) Alpha-adrenergic receptor subtypes. N Engl J Med 302: 1390–1395

    Article  PubMed  CAS  Google Scholar 

  8. Bylund DB, U’Pritchard DC (1983) Characterisation of alpha, and alpha,-adrenergic receptors. Int Rev Neurobiol 24: 343–431

    Article  PubMed  CAS  Google Scholar 

  9. U’Prichard DC, Snyder SH (1979) Distinct alpha-noradrenergic receptors differentiated by binding and physiological relationships. Life Sci 24: 79–88

    Article  PubMed  Google Scholar 

  10. Scholz H, Bruckner R (1982) Effects of beta-and alpha-adrenoceptor stimulating agents on mechanical activity, electrophysiological parameters and cyclic nucleotide levels in the heart. In: Caldarera CR, Harris P (eds) Advances in studies on heart metabolism. CLUEB, Bologna

    Google Scholar 

  11. Adler-Graschinsky E, Langer SZ (1975) Possible role of a beta-adrenoreceptor in the regulation of noradrenaline release by nerve stimulation through a positive feed-back mechanism. Br J Pharmacol 53: 43–40

    Article  PubMed  CAS  Google Scholar 

  12. Kawasaki H, Clive WH, Su C (1982) Enhanced presynaptic beta-adrenoreceptor-mediated modulation of vascular adrenergic neurotransmission in spontaneously hypertensive rats. J Pharmacol Exp Ther 223: 721–728

    PubMed  CAS  Google Scholar 

  13. Rosendorff C, Cranston WI (1971) Effects of intrahypothalamic and intraventricular nor-adrenaline and 5-hydroxytryptamine on hypothalamic blood flow in the conscious rabbit. Circ Res 28: 492–502

    Article  PubMed  CAS  Google Scholar 

  14. Bomzon L, Rosendorff C, Scriven DRL, Farr J (1975) The effect of noradrenaline, adrenergic blocking agents and tyramine on the intrarenal distribution of blood flow in the baboon. Cardiovasc Res 9: 314–322

    Article  PubMed  CAS  Google Scholar 

  15. Rosendorff C, Hoffman JIE, Verrier E, Rouleau JR, Boerboom LE (1981) Cholesterol sensitizes coronary vessels to norepinephrine. Circ Res 48: 320–329

    Article  PubMed  CAS  Google Scholar 

  16. Pappano AJ (1976) Onset of chronotropic effects of nicotinic drugs and tyramine on the sino-atrial pacemaker in chick embryo heart; relationship to the development of autonomic neuroeffector transmission. J Pharmacol Exp Ther 196: 676–684

    PubMed  CAS  Google Scholar 

  17. Vatner DE, Lee DL, Schwarz KR, Longabaugh JP, Fujii AM, Vatner SF, Homcy CJ (1988) Impaired cardiac muscarinic receptor function in dogs with heart failure. J Clin Invest 81: 1836–1842

    Article  PubMed  CAS  Google Scholar 

  18. Prokopczuk A, Pytkowski B, Lawartowski B (1981) Effect of acetylcholine on calcium efflux from atrial myocardium. Eur J Pharmacol 70: 1–6

    Article  PubMed  CAS  Google Scholar 

  19. Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK (1987) Cloning of the cDNA for the human beta-adrenergic receptor. Proc Natl Acad Sci USA 84: 7920–7924

    Article  PubMed  CAS  Google Scholar 

  20. Kobilka BK, Matsui HG, Kobilka TA, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ, Regan JW (1987) Cloning, sequencing, and expression of the gene coding for the human platelet alpha,-adrenergic receptor. Science 238: 650–656

    Article  PubMed  CAS  Google Scholar 

  21. Regan JW, Kobilka TS, Yang-Feng TL, Caron MG, Lefkowitz RJ, Kobilka BK (1988) Cloning and expression of a human kidney cDNA for an alpha -adrenergic receptor subtype. Proc Natl Acad Sci USA 85: 6301–6305

    Article  PubMed  CAS  Google Scholar 

  22. Cotecchia S, Schwinn DA, Randall RR, Lefkowtiz RJ, Caron MG, Kobilka BK (1988) Molecular cloning and expression of the cDNA for the hamster alpha, -adrenergic receptor. Proc Natl Acad Sci USA 85: 7159–7163

    Article  PubMed  CAS  Google Scholar 

  23. Peralta EG, Winslow JW, Peterson GL, Smith DH, Ramachandran J, Schimerlik MI, Capon DJ. Ashkenazi A (1987) Primary structure and biochemical properties ofan M2 muscarinic receptor: Muscarinic subtypes are distinct gene products. Science 236: 600–605

    Article  PubMed  CAS  Google Scholar 

  24. Rosendorff C, Susanni E, Hurwitz ML, Ross FP (1985) Adrenergic receptors in hypertension: radioligand binding studies. J Hypertension 3: 571–581

    Article  CAS  Google Scholar 

  25. Bristow MR, Ginsburg R, Minobe W et al. (1982) Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. N Engl J Med 307: 205–211

    Article  PubMed  CAS  Google Scholar 

  26. Ruffolo RR, Kopia GA (1986) Importance of receptor regulation in the pathophysiology and therapy of congestive heart failure. Am J Med [Suppl 2B] 80: 67–72

    Article  Google Scholar 

  27. Baumann G, Mercader D. Busch U et al. (1983) Effects of the H_,-receptor agonist impromidine in human myocardium from patients with heart failure due to mitral an aortic valve disease. J Cardiovasc Pharmacol 5: 618–625

    Article  PubMed  CAS  Google Scholar 

  28. Francis GS, Cohn JN (1986) The autonomic nervous system in congestive heart failure. Ann Rev Med 37: 235–247

    Article  PubMed  CAS  Google Scholar 

  29. Williams RS (1983) Selectivity of prenalterol for adrenergic receptor subtypes: a potential mechanism of inotropic selectivity. J Cardiovasc Pharmacol 5: 266–271

    Article  PubMed  CAS  Google Scholar 

  30. Bristow MR, Ginsburg R, Umans V. Fowler M, Minobe W. Rasmussen R. Zera P. Menlove R. Shah P, Jamieson S, Stinson EB (1986) Beta,–and beta.,-adrenergic receptor subpopulations in nonfailing and failing human ventricular myocardium: compiling of both receptor subtypes to muscle contraction and selective beta, -receptor down regulation in heart failure. Cire Res 59: 297–309

    Article  CAS  Google Scholar 

  31. Limas CJ, Limas C’ (1984) Rapid recovery of cardiac beta-adrenergic receptors after isoproterenol-induced “down”-regulation. Circ Res 55: 524–531

    Article  PubMed  CAS  Google Scholar 

  32. Limas O. Goldenberg IF, Limas C (1989) Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy. Circ Res 64: 97–103

    Article  PubMed  CAS  Google Scholar 

  33. Vago T, Bevilaqua M, Norbiato G, Baldi G, Chebat E, Bertora P. Baroldi G. Accinni R (1989) Identification of alpha,-adrenergic receptors on sarcolemma from nomal subjects and patients with idiopathic dilated cardiomyopathy: characteristics and linkage to GTP-binding protein. Circ Res 64: 474–481

    Article  PubMed  CAS  Google Scholar 

  34. Harris P, Harding SE (1986) The molecular actions of beta-agonists in the cardiac sarcolemma. J Cardiovasc Pharmacol [Suppl 3] 8:S10–S1 I

    Google Scholar 

  35. Weiss ER, Kelleher DJ, Woon CW, Soparkar S, Osawa S, Heasley LE, Johnson GL (1988) Receptor activation of G-proteins. FASEB, 1 2: 2841–2848

    Google Scholar 

  36. Shenolikar S (1988) Protein phosphorylation: hormones, drugs, and bioregulation. FASEB J 2: 2753–2764

    PubMed  CAS  Google Scholar 

  37. Rosenthal W. Herscheller J. Trautwein W. Schultz G (1988) Control of voltage dependent Ca=–channels by G protein-coupled receptors. FASEB J 2: 2784–2790

    PubMed  CAS  Google Scholar 

  38. Feldman AM, Cates AE, Veazey WB, Herschberger RE. Bristow MR, Baughman KL, Baumgartner WA, Van Dop C (1988) Increase of the 40000-mol wt pertussis toxin substrate ( G-protein) in the failing human heart. J Clin Invest 82: 189–197

    Article  PubMed  CAS  Google Scholar 

  39. Ransnas LA, Hjalmarson A. Insel PA (1988) Dilated cardiomyopathy is associated with an impaired activation of the stimulatory G-protein, Gs, by GTP in heart membranes (abstract). Circulation 78 (Suppl 11): 11–178

    Google Scholar 

  40. Horn EM, Corwin SJ, Steinberg SF, Chow YK, Neuberg GW, Cannon PJ, Powers ER, Bilezikian JP (1988) Reduced lymphocyte stimulatory guanine nucleotide regulatory protein and betaadrenergic receptors in congestive heart failure and reversal with angiotensin converting enzyme inhibitor therapy. Circulation 78: 1373–1379

    Article  PubMed  CAS  Google Scholar 

  41. Insel PA, Ransnas LA (1988) G-proteins and cardiovascular disease. Circulation 78: 1511–1513

    Article  PubMed  CAS  Google Scholar 

  42. Feldman MD, Copelas L, Gwathmey JK, Phillips P, Warren SE, Schoen FJ, Grossman W, Morgan JP (1987) Deficient production of cyclic AMP: pharmacologie evidence ofan important cause of contractile dysfunction in patients with end-stage heart failure. Circulation 75: 331–339

    Article  PubMed  CAS  Google Scholar 

  43. Gwathmey JK, Copelas L, MacKinnon R, Schoen RI, Feldman MD. Grossman W. Morgan JP (1987) Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res 61: 70–76

    Article  PubMed  CAS  Google Scholar 

  44. Wetzel B, Hauel N (1988) New cardiotonic agents — a promising approach for the treatment of heart failure. Trends Pharmacol Sci 9: 116–170

    Article  Google Scholar 

  45. Maskin CS, Kugler J, Sonnenblick EH, Le Jemtel TH (1983) Acute inotropic stimulation with dopamine in severe congestive heart failure: beneficial hemodynamic effect at rest but not during maximal exercise. Am J Cardiol 52: 1028–1032

    Article  PubMed  CAS  Google Scholar 

  46. Cantelli J, Lolli C, Bomba E, Brunelli D, Bracchetti D (1986) Ibopamine. CurrTher Res Clin Exp 39: 900–911

    Google Scholar 

  47. Chatterjee K, Bendersky R, Parmley WW (1982) Dobutamine in heart failure. Eur HeartJ [Suppl D] 3: 107–114

    Google Scholar 

  48. Thompson MJ, Juss P, Unverferth DV, Fasola A, Leier CV (1980) Hemodynamic effects of intravenous butopamine in congestive heart failure. Clin Pharmacol Ther 28: 324–334

    Article  PubMed  CAS  Google Scholar 

  49. Ikeo T, Nagao T, Murata S, Yabana H, Sato M, Nakajima H (1986) Cardiovascular effects of the new positive inotropic agent denopamine with special reference to species difference and the effect on the failing heart. Arzneimittelforsch 36: 1063–1068

    PubMed  CAS  Google Scholar 

  50. Lambertz H, Meyer J, Erbel R (1984) Long-term hemodynamic effects ofprenalterol in patients with severe congestive heart failure. Circulation 69: 298–305

    Article  PubMed  CAS  Google Scholar 

  51. Molajo AO, Bennett DH (1985) Effectofxamoterol (ICI 118587), a new beta adrenoceptorpartial agonist, on resting haemodynamic variables and exercise tolerance in patients with left ventricular dysfunction. Br Heart J 54: 17–21

    Article  PubMed  CAS  Google Scholar 

  52. Bristow MR, Ginsburg R, Strosberg A, Montgomery W, Minobe W (1984) Pharmacology and inotropic potential of forskolin in the human heart. J Clin Invest 74: 212–223

    Article  PubMed  CAS  Google Scholar 

  53. Alousi AA, Johnson DC (1986) Pharmacology of the bipyridines: amrinone and milrinone. Circulation 73 III: 10–24

    Article  Google Scholar 

  54. Maskin CS, Weber KT, Janicki JS (1987) Long-term oral enoximone therapy in chronic cardiac failure. Am J Cardiol 60: 63C - 67C

    Article  PubMed  CAS  Google Scholar 

  55. Iijima T, Taira N (1987) Membrane current changes responsible for the positive inotropic effect of OPC-8212, a new positive inotropic agent, in single ventricular cells of the guinea pig heart. J Pharmacol Exp Ther 240: 657–662

    PubMed  CAS  Google Scholar 

  56. Bristol JA, Sircar J, Moos WH, Evans DB, Weishaar RE (1984) Cardiotonic agents 1. 4,5dihydro-644-(1 H-imidazol-1-yl) phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure. J Med Chem 27: 1099–1101

    Article  PubMed  CAS  Google Scholar 

  57. Schramm M, Bechem M, Franchowiak G, Gro R, Thomas G (1985) One enantiomer of the positive inotropic dihydropyridine Bay K 8644 is a calcium-antagonist. J Mol Cell Cardiol 17 [Supp13]: 201

    Google Scholar 

  58. Laurent S, Kim D, Smith TW, Marsh JD (1985) Inotropic effect, binding properties, and calcium flux effects of the calcium channel agonist CGP 28392 in intact cultured embryonic chick ventricular cells. Circ Res 56: 676–682

    Article  PubMed  CAS  Google Scholar 

  59. Hagemeijer F, Segers A, Schelling A (1984) Cardiovascular effects of sulmazol administered intravenously to patients with severe heart failure. Eur Heart J 5: 158–167

    PubMed  CAS  Google Scholar 

  60. Freund P, Muller-Bechmann B, Strein K, Kling L, Ruegg JC (1987) Cat -sensitizing effects of BM 14,478 on skinned cardiac muscle fibres of guinea pig papillary muscle. Eur J Pharmacol 136: 243–246

    Article  PubMed  CAS  Google Scholar 

  61. Kitada Y, Narimatsu A, Matsumura N, Endo M (1987) Contractile proteins: possible targets for the cardiotonic action of MCI-154, a novel cardiotonic agent? Eur J Pharmacol 134: 229–231

    Article  PubMed  CAS  Google Scholar 

  62. Scholtysik G, Salzmann R, Berthold R, Herzig JW, Quast U, Markstein R (1985) DPI 201–106, a novel cardioactive agent. Combination of cAMP-independent positive inotropic, negative chronotropic, action potential prolonging and coronary dilatory properties. Naunyn Schmiedebergs Arch Pharmacol 329: 316–325

    Article  PubMed  CAS  Google Scholar 

  63. Anon (1986) Pimobendan. Drugs Future 11: 625–626

    Google Scholar 

  64. Fritsche R, Scheid HH, Van Meel JCA, Hehrlein W (1986) Effect of pimobendan on calcium sensitivity of skinned fibres isolated from human papillary muscles. Br J Pharmacol 89: 751 P

    Google Scholar 

  65. Paton DM, Manuel JM (1988) Mechanisms of action of the new cardiotonic drugs. Trends Pharmacol Sci 9: 431–432

    Article  PubMed  CAS  Google Scholar 

  66. Parsons WJ, Rankumar V, Stiles GL (1988) The new cardiotonic agent sulmazole is an A, adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi. Mol Pharmacol 33: 441–448

    PubMed  CAS  Google Scholar 

  67. Cavero I, Massingham R, Lefevre-Borg F (1982) Peripheral dopamine receptors, potential targets for a new class of antihypertensive agents. Life Sci 31: 1059–1069

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. C. Rosendorff
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Editors and Affiliations

  1. Department of Cardiology, Lady Davis Carmel Hospital, 34362, Haifa, Israel

    Basil S. Lewis MD (Director) (Director)

  2. University of California, Los Angeles, USA

    Asher Kimchi MD (Assistant Clinical Professor of Medicine, Attending Physician) (Assistant Clinical Professor of Medicine, Attending Physician)

  3. Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA

    Asher Kimchi MD (Assistant Clinical Professor of Medicine, Attending Physician) (Assistant Clinical Professor of Medicine, Attending Physician)

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© 1991 Springer-Verlag Berlin Heidelberg

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Rosendorff, C. (1991). Autonomic Receptor Function in Congestive Heart Failure. In: Lewis, B.S., Kimchi, A. (eds) Heart Failure Mechanisms and Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58231-8_1

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  • DOI: https://doi.org/10.1007/978-3-642-58231-8_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63509-0

  • Online ISBN: 978-3-642-58231-8

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