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Tissue Engineering in Cartilage Repair

Zellaugmentierte Matrixsysteme zur Wiederherstellung von Gelenkknorpel

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Part of the book series: Fortbildung Orthopädie ((FORTORTHO,volume 3))

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Zusammenfassung

Die eingeschränkte Heilungsfähigkeit von Gelenkknorpel ist seit mehr als drei Jahrhunderten in der Literatur beschrieben [1, 2] und noch immer ein aktuelles Thema in der Orthopädie. Diese Einschränkungen des Gelenkknorpels stehen im eingen Zusammenhang mit dem Fehlen von Gefäßen, der geringen Mitoserate der Knorpelzellen und dem Mangel von chondrogenen Zellen im Knorpeldefekt. Mögliche Heilungsprozesse finden über Einblutung aus dem subchondralen Knochen, pluripotente Stammzellen aus dem Knochenmark oder synovialen Faktoren und Zellen statt [3]. Dieser Reparaturversuch endet aber meist mit der Bildung von fibrokartilaginärem Narbengewebe, welches die mechanischen Eigenschaften von Knorpel auf lange Sicht nicht erreichen kann. Wird der subchondrale Knochen nicht verletzt und keine Blutung induziert, findet meist überhaupt kein Heilungsprozeß statt und der Defekt bleibt zunächst unverändert bestehen [4].

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Literatur

  1. Hunter W (1743) Of the structure and diseases of articulating cartilates. Philosophical Transactions 470: 514–521

    Google Scholar 

  2. Paget J (1853) Healing of injuries in various tissues. Lect Surg Path (London) 1: 262

    Google Scholar 

  3. Buckwalter J, Rosenberg L, Coutts R, Hunzider E, Reddi A, Mow V (1988) Atricular cartilage: injury and repair of the musculoskeletal soft tissues. In: Woo SY, Buckwalter J (eds) AAOS, Park Ridge IL, pp 465–482

    Google Scholar 

  4. Mankin H (1982) The response of articular cartilage to mechanical injury. J Bone Joint Surg 64: 460–466

    PubMed  CAS  Google Scholar 

  5. Convery FR, Akeson WH, Keown GH (1972) The repair of large osteochondral defects. An experimental study in horses. Clin Orthop Rel Res 82: 253–262

    CAS  Google Scholar 

  6. Johnson L (1991) Characteristics of the immediate postarthroscopic blood clot formation in the knee joint. Arthroscopy 7: 14–23

    Article  PubMed  CAS  Google Scholar 

  7. Johnson L (1991) Arthroscopic abrasion arthroplasty. Raven Press, New York

    Google Scholar 

  8. O’Driscoll SW, Keeley FW, Salter RB (1988) Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major fullthickness defects in joint surfaces under the influence of continuous passive motion. J Bone Joint Surg 70A: 595–606

    Google Scholar 

  9. O’Driscoll S, Recklies A, Poole A (1994) Chondrogenesis in periosteal expiants. J Bone Joint Surg 76A: 1042–1051

    Google Scholar 

  10. Engkvist O, Ohlsen L (1979) Reconstruction of articular cartilage with free autologous perichondrial grafts. Scandinavian Journal of Plastic and Reconstructive Surgery 13: 269–274

    Article  PubMed  CAS  Google Scholar 

  11. Homminga GN, Bulstra S, Bouwemeester PSM, Van der Linden AJ (1990) Perichondral grafting for cartilate lesions of the knee. J Bone Joint Surg 72B: 1003–1007

    Google Scholar 

  12. Brittberg M, Lindahl A, Nilson A, Ohlson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331: 889–895

    Article  PubMed  CAS  Google Scholar 

  13. Brittberg M, Nilsson A, Lindahl A, Ohlsson C, Peterson L (1996) Rabbit articular cartilage defects treated with autologous cultured chondrocytes. Clinical Orthopedics and Related Research 326: 270–283

    Article  Google Scholar 

  14. Freed L, Marquis J, Nohria A, Emmanual J, Mikos A, Langer R (1993) Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J Biomed Mater Res 27: 11–23

    Article  PubMed  CAS  Google Scholar 

  15. Freed LE, Grande DA, Lingbin Z, Emmanual J, Marquis JC, Langer R (1994) Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds. J Biomed Mater Res 28: 891–899

    Article  PubMed  CAS  Google Scholar 

  16. Caplan A, Fink D, Goto T, Linton A, Young R, Wakitani S, Goldberg V, Haynesworth S (1993) Mesenchymal stem cells and tissue repair. Raven Press Ltd, New York

    Google Scholar 

  17. Ben-Yishay A, Grande D, Schwartz R, Menche D, Pitman M (1995) Repair of articular cartilage defects with collagen-chrondrocyte allografts. Tissue Engineering 1: 119–133

    Article  PubMed  CAS  Google Scholar 

  18. Frenkel S, Toolan B, Pittman MT, Pachenne JM (1997) A novel collagen bilayer matrix for articular cartilage repair. J Bone Joint Surg 79B: 831–836

    Article  Google Scholar 

  19. Nehrer S, Ramappa A, Breinan H, Shortkroff S, Yanna I, Spector M (1996) Chondrocyte-seeded type I and type II collagen implants investigated in vitro. Fifth World Biomaterials Congress, Toronto, CA, pp 290

    Google Scholar 

  20. Nehrer S, Breinan H, Ramappa A, Young G, Shortkroff S, Louie L, Sledge C, Yannas J, Spector M (1997) Matrix collagen type and pore size influence behavior of seeded canine chondrocytes. Biomaterials 18: 769–776

    Article  PubMed  CAS  Google Scholar 

  21. Nehrer S, Breinan H, Ramappa A, Shortkroff S, Young G, Minas T, Sledge C, Yannas J, Spector M (1997) Canine chondrocytes seeded in type I and type II collagen implants investigated in vitro. J Biomed Mat Res 38: 95–104

    Article  CAS  Google Scholar 

  22. Nehrer S, Breinan H, Ramappa A, Hsu HP, Shortkroff S, Minas T, Spector M (1998) Chondrocyteseeded collagen matrices implanted in a chondral defect in a canine model. J Biomaterials 9: 2313–2328

    Article  Google Scholar 

  23. Breinan H, Minas T, Hu-Ping H, Nehrer S, Sledge C, Spector M (1997) Effect of cultured autologous chondrocytes on repair of chondral defects in a canine model. J Bone Joint Surg 79A: 1439–1451

    Google Scholar 

  24. Shapiro F, Koide S, Glimscher MJ (1993) Cell origin and differentiation in the repair of full thickness defects of articular cartilage. J Bone Joint Surg 75A: 523–553

    Google Scholar 

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Authors
  1. S. Nehrer
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Editors and Affiliations

  1. Abteilung und Poliklinik für Sportorthopädie, TU München, Connollystraße 32, 80809, München, Germany

    Andreas B. Imhoff

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© 2000 Springer-Verlag Berlin Heidelberg

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Nehrer, S. (2000). Tissue Engineering in Cartilage Repair. In: Imhoff, A.B. (eds) Knie. Fortbildung Orthopädie, vol 3. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57733-8_13

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  • DOI: https://doi.org/10.1007/978-3-642-57733-8_13

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-7985-1181-1

  • Online ISBN: 978-3-642-57733-8

  • eBook Packages: Springer Book Archive

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