Abstract
Cerebral complications are a major cause of morbidity after cardiac surgery. Ischemic stroke with neurological deficits can be very disabling for the patient, e.g., when the localization of the ischemia results in a hemiparesis. Whereas a minor ischemic lesion or a lesion with a more favorable localization does give such devastating symptoms. Still the incidence of a stroke, i.e., a regional ischemia with neurological symptoms, after cardiac surgery has been reported to occur between 0.7-5.2% (Lynn et al., 1985).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Astudillo R, Van der Linden J, Radegran K, Hansson L-O, Åberg B (1996) Elevated serum levels of S-100 after deep hypothermie arrest correlate with duration of circulatory arrest. Eur J Cardiothorac Surg 10:1107–1113
Blomquist S, Johnsson P, Lührs C, Malmkvist G, Solem J-O, Alling C et al (1997) The appearence of S-100 protein in serum during and immediately after cardiopulmonary bypass surgery. A possible marker for cerebral injury. J Cardiothorac Vasc Anesth 11:699–703
Büttner T, Weyers S, Postert T, Sprengelmeyer R, Kuhn W (1997) S-100 protein: Serum marker of focal brain damage after ischemic territorial MCA infarction. Stroke 28:1961–1965
Haimoto H, Hosoda S, Kato K (1987) Differential distribution of immunoreactive S100-alpha and S100-beta proteins in normal nonnervous human tissues. Lab Invest 57(5):489–498
Jönsson H, Johnsson P, Alling C, Westaby S, Blomquist S (1998) Significance of serum S100 release after coronary artery surgery. Ann Thorac Surg
Jönsson H, Johnsson P, Alling C, Bäckström M, Bergh C, Blomquist S (in press) S100B after coronary artery surgery: release pattern, source of contamination and relation to neuropsychological outcome. Ann Thorac Surg
Kligman D, Hilt DC (1988) The S100 protein family. Trends Biochem Sci 13(11):437–443
Lynn GM, Stefanko K, Reed JF (1992) Risk factors for stroke after coronary artery bypass. J Thorac Cardiovasc Surg 104:1518–1523
Mahanna EP, Blumenthal JA, White WD, Croughwell ND, Clancy CP, Smith LR et al (1996) Defining neuropsychological dysfunction after coronary artery bypass grafting. Ann Thorac Surg 61:1342–1347
Rosen H, Rosengren L, Herlitz J, Blomstrand C (1998) Increased serum levels of the S-100 protein are associated with hypoxic brain damage after cardiac arrest. Stroke 29:473–477
Sandström E, Svenmarker S, Karlsson K, Aberg T (1996) S-100 and memory function after cardiac surgery. European association of cardiothoracic surgery, meeting Prague
Taggart DP, Bhattacharya K, Meston N, Standing S, Kay J, Pillai R et al (1997) Serum S-100 protein concentration after cardiac surgery: a randomized trial of arterial line filtration. Eur J Cardiothorac Surg 11:645–649
Taggart DP, Mazel JW, Bhattacharya K, Meston N, Standing SJ, Kay JD et al (1997) Comparison of serum S-100 beta levels during CABG and intracardiac operations. Ann Thorac Surg 63(2):492–496
Zimmer DB, Cornwall EH, Landar A, Song W (1995) The S100 protein family: history, function, and expression. Brain Res Bull 37(4):417–429
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Jönsson, H. (2000). S100B as a diagnostic tool for brain damage after cardiac surgery. In: Baykut, D., Krian, A. (eds) Current Perspectives of the Extracorporeal Circulation. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57721-5_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-57721-5_10
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-7985-1214-6
Online ISBN: 978-3-642-57721-5
eBook Packages: Springer Book Archive