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Sofortdiagnose und Soforttherapie durch den zuerst eintreffenden Arzt

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Die Notfalltherapie bei akutem Myokardinfarkt
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Abstract

Prehospital diagnosis and first line therapy of acute chest pain are among the most frequently encountered challenges for general practitioners and emergency physicians. Acute myocardial infarction or acute coronary syndromes in general are present in about a third of patients complaining of acute chest pain. The basis of first line therapy is the understanding of the pathophysiology of myocardial ischemia, the clinical symptoms, the diagnostic tools and the preclinically available therapeutic options. Time is the most critical factor in myocardial ischemia and subsequent infarction with irreversible injury of subendocardial cells starting within 30–60 minutes of total myocardial ischemia and with transmural infarction becoming complete in 3 to 6 hours. With 30% of patients dying within the first hour of ischemia mostly due to ventricular arrhyhtmias every effort needs to be made to shorten the delay between symptom onset and start of reperfusion therapy. The present overview concentrates on the armamentarium of preclincial diagnosis and the options of first line therapy of myocardial infarction with the aim of a short transport time to the hospital and therefore a short delay to more specific therapies like thrombolysis or PTCA.

Zusammenfassung

Die präklinische Notfallbehandlung des akuten Thoraxschmerzes zählt zu den häufigsten Einsätzen des Notarztes, wo- bei bei ca. einem Drittel der Patienten ein akuter Myokardinfarkt oder im weiteren Sinne ein akutes Koronarsyndrom vorliegt. Zur akuten Behandlung bedarf es einer klaren Vorstellung von der Pathogenese, der klinischen Symptomatik, der möglichen Akutdiagnostik und den therapeutischen Optionen. Dabei spielt der Faktor Zeit die entscheidenden Rolle! Aufgrund der geringen Ischämietoleranz des Myokards bestimmt die Zeit zwischen Symptombeginn und Wiedereröffnung des Infarktgefäßes einerseits den Erfolg der Reperfusionstherapie und andererseits sterben in der ersten Infarktstunde schon ca. 30% der Patienten vorrangig durch auftretenden ventrikuläre Herzrhythmusstörungen. In der vorliegenden Übersicht wird auf die akute präklinische Diagnostik und mögliche Therapie ausführlich eingegangen, mit dem Ziel der sofortigen Einleitung einer spezifischen Therapie, der sicheren Überwachung und des sicheren Transportes des Patienten in die Klinik.

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Literatur

  1. ACC/AHA Guidelines for the Management of patients with acute myocardial infarction. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Manangement of acute myocardial infarction) (1996) J Am Coll Cardiol 28: 1328–1428

    Article  Google Scholar 

  2. Arnout J, Simoons M, DeBono D, Rapold HJ, Collen D, Verstraete M (1992) Correlation between level of heparinization an patency of the infarct-related coronary artery after treatment of acute myocardial infarction with alteplase (rt-PA). J Am Coll Cardiol 20:513–519

    Article  PubMed  CAS  Google Scholar 

  3. Bertini G, Giglioli C, Rostagno C et al. (1993) Early out-of hospital lidocain administration decreases the incidence of primary ventricular fibrillation in acute myocardial infarction. J Emerg Med 11:667–672

    Article  PubMed  CAS  Google Scholar 

  4. De Winter RJ, Koster RW, Sturk A, Sanders GT (1995) Value of Myoglobin, Troponin T and CK-MB-mass in Ruling Out an Acute Myocardial Infarction in the Emergency Room. Circulation 92:3401–3407

    Article  PubMed  Google Scholar 

  5. De Wood MA, Spores J, Motske R, et al. (1980) Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 303:897–902

    Article  Google Scholar 

  6. Eisenberg MJ, Topol EJ (1996) Pre-hospital administration of aspirin in patients with unstable angina and acute myocardial infarction. Arch Intern Med 156:1506–1510

    Article  PubMed  CAS  Google Scholar 

  7. European Resuscitation Council (1992) Guidelines for basic and advanced life support. Resuscitation 24: 103–121

    Article  Google Scholar 

  8. Falk E (1983) Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis: characteristics for coronary artherosclerotic plaque underlying fatal occlusion thrombi. Br Heart J 50:127–134

    Article  PubMed  CAS  Google Scholar 

  9. Fillmore SJ, Shapiro M, Killip T (1970) Arterial oxygen tension in acute myocardial infarction. Serial analysis of clinical state and blood gas changes. Am Heart J 79:620

    Google Scholar 

  10. GISSI-1 Collaborative Group (1986) Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1:397–402

    Google Scholar 

  11. Granger CG, Califf RM (1995) Stabilizing the unstable artery. In: Califf RM, Mark DM, Wagner GS (eds) Acute coronary care, 2nd ed. Mosby-Year Book, St. Louis S 525–541

    Google Scholar 

  12. Hamm CW, Goldmann BU, Heeschen C, Kreymann G, Berger J, Meinertz T (1997) Emergency Room Triage of Patients with Acute Chest Pain by means of rapid testing for Cardiac Troponin T or I. NEJM 337:1648–1653

    Article  PubMed  CAS  Google Scholar 

  13. Hamm CW, Rankilde J, Gerhardt W et al. (1992) The prognostic value of serum troponin T in unstable angina. N Engl J Med 342:145–150

    Google Scholar 

  14. Hausmann D, Drexler H. (1998) Das akute Koronarsyndrom. Der Internist 39:133–141

    Article  PubMed  CAS  Google Scholar 

  15. Herlitz J, Hjalmarson A, Waagstein F (1989) Treatment of pain in acute myocardial infarction. Br Heart J 61: 69

    Article  Google Scholar 

  16. Hine LK, Laird N, Hewitt P et al. (1989) Meta-analytic evidence against prophylactic use of lidocain in acute myocardial infarction. Arch Intern Med 149:2694

    Article  PubMed  CAS  Google Scholar 

  17. ISIS-1 (First International Study of Infarct Survival) Collaborative Group (1986) Randomised trial of intravenous atenolol among 16077 cases of suspected acute myocardial infarction. Lancet 2:57–66

    Google Scholar 

  18. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group (1989) Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 2:182–186

    Google Scholar 

  19. ISIS-3 (Third International Study of Infarct Survival) Collaborative Group (1993) A rondomised comparison of streptokinase vs tissue plasminogen activator vs. anisteplase and of aspirin plus heparin vs. aspirin alone among 41299 cases of suspected acute myocardial infarction. Lancet 339: 753–770

    Google Scholar 

  20. Katus HA, Remppis A, Looser S et al. (1989) Enzyme linked immunoassay of cardiac troponin T for detection of acute myocardial infarction in patients. J Mol Cell Cardiol 21:1349–1353

    Article  PubMed  CAS  Google Scholar 

  21. Ohman EM, Armstrong PW, Christenson RH, Granger CB, Katus HA, Hamm CW, O’Hanesian MA, Wagner GS, Kleiman NS, Harell FE, Califf RM, Topol EJ, for the GUSTO-IIa Investigators (1996) Cardiac Troponin T Level for Risk Stratification in Acute Myocardial Ischemia NEJM 335: 1333–1341

    Article  PubMed  CAS  Google Scholar 

  22. Roberts R, Rogers WJ, Mueller SH et al. (1991) Immediate versus deferred beta blockade following thrombolytic therapy in patients with acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI)II-B Study. Circulation 83: 422–437

    Article  PubMed  CAS  Google Scholar 

  23. Roun GW, Lee TH, Cook EF et al. (1989) Clinical characteristics and outcome of acute myocardial infartion in patients with initially normal or nonspecific electrocardiogram (a report from the Multicenter Chest Pain Study). Am J Cardiol 64:1087–1092

    Article  Google Scholar 

  24. Roux S, Christeller S, Lüdin E (1992) Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: A metaanalysis. J Am Coll Cardiol 19:671–677

    Article  PubMed  CAS  Google Scholar 

  25. Rozeman Y, Gotsman MS (1994) The earliest diagnosis of acute myocardial infarction Annu Rev Med 45:31–44

    Article  Google Scholar 

  26. Schaper W (1990) Der aktuelle Stand der experimentellen Herzinfarktforschung. Z Kardiol 79:811–818

    PubMed  CAS  Google Scholar 

  27. Schwartz L, Bourassa MG, Lesperance J et al. (1988) Aspirin and Dipyridamole in the prevention of restenosis after percutaneus transluminal coronary angioplasty. N Engl J Med 318: 1714–1719

    Article  PubMed  CAS  Google Scholar 

  28. Sorges E, Götz J, Carlsson J, Tebbe U (1998) Rationelle Diagnostik bei kardialen Notfällen Intensiv-und Notfallbehandlung 23:2–12

    Google Scholar 

  29. Störk T, Möckel M (1998) Beitrag des Labors zur Diagnostik und Risikostratifikation bei akuten Koronarsyndromen in der klinischen Routine (NOWIS) Intensivmed 35:42–49

    Article  Google Scholar 

  30. Tebbe U, Carlsson J (1998) Kardiopulmonale Reanimation — Darstellung und Kommentar aktueller Richtlinien. Der Internist 39:179–187

    Article  PubMed  CAS  Google Scholar 

  31. The GUSTO Investigators (1993) An international randomised trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 329:673–682

    Article  Google Scholar 

  32. VANQWISH-(Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital) Trial Investigators (1998) Outcomes in patients with acute non-Q-wave myocardial infarction randomly assigned to an invasive as compared with a conservative management strategy. N Eng J Med 338:1785–1793

    Article  Google Scholar 

  33. Wellens HHW, Conover MB (1992) In: The ECG in emergency decision making. Saunders, Philadelphia

    Google Scholar 

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Sorges, E., Carlsson, J., Miketic, S., Kirchner, A., Tebbe, U. (2000). Sofortdiagnose und Soforttherapie durch den zuerst eintreffenden Arzt. In: Arntz, HR., Schuster, HP. (eds) Die Notfalltherapie bei akutem Myokardinfarkt. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57713-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-57713-0_5

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-7985-1247-4

  • Online ISBN: 978-3-642-57713-0

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