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Manipulation of SERCA2a in the heart by gene transfer

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Molecular Approaches to Heart Failure Therapy

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Abstract

In the myopathic heart, a number of abnormalities have been delineated (Fig. 1) at the cellular level [25-33, 35, 38-43]. These include changes at the level of the sarcolemma, sarcoplasmic reticulum, myofilaments, and mitochondria, all of which contribute to depressed contractile function and reserve [25-33, 35, 38-43]. Identifying the mechanisms by which these changes contribute to the observed pathology is frequently confounded by simultaneous alterations in multiple signaling pathways in the complex milieu of the failing heart. Targeting genes to the heart through somatic gene transfer allows us to identify and characterize the molecular changes of diseases as well as to manipulate the targeted pathways [34, 36, 37].

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Authors and Affiliations

  1. Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA

    F. Del Monte & R. J. Hajjar

  2. Cardiac Medicine, National Heart Lung Institute, Imperial College of Medicine, London, UK

    S. E. Harding

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  1. F. Del Monte
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  2. S. E. Harding
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  3. R. J. Hajjar
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Editors and Affiliations

  1. Zentrum Innere Medizin, Abt. Kardiologie und Pneumologie, Georg-August-Universität Göttingen, Robert-Koch-Straße 40, Göttingen, D-37075, Germany

    Gerd Hasenfuss

  2. Section of Molecular and Cellular Cardiology, The Johns Hopkins University, 844 Ross Building, Baltimore, MD, 21205, USA

    Eduardo Marbán M.D., Ph.D. (Professor of Medicine and Physiology) (Professor of Medicine and Physiology)

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Del Monte, F., Harding, S.E., Hajjar, R.J. (2000). Manipulation of SERCA2a in the heart by gene transfer. In: Hasenfuss, G., Marbán, E. (eds) Molecular Approaches to Heart Failure Therapy. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57710-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-57710-9_5

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63332-4

  • Online ISBN: 978-3-642-57710-9

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