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Genetic approaches to elucidate the regulatory role of phospholamban in the heart

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Molecular Approaches to Heart Failure Therapy

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Abstract

In end-stage heart failure, several molecular, biochemical and functional alterations have been described to occur at the cellular level [11, 32]. Evidence indicates that disturbed excitation-contraction coupling processes may underlie disturbed myocardial function in various animal models and human conditions [3, 34]. Specifically, Ca2+ uptake and release by the sarcoplasmic reticulum (SR) have been shown to be altered, and the ratio of phospholamban/SR Ca2+ ATPase has been suggested to play a key role in the pathophysiology of heart failure [10]. Thus, it becomes important to dissect the molecular mechanisms governing the highly regulated excitation-contraction coupling process and their alterations in heart failure in order to develop new therapeutic approaches for this disease.

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Authors and Affiliations

  1. Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA

    A. G. Schmidt & E. G. Kranias

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  1. A. G. Schmidt
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  2. E. G. Kranias
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Editors and Affiliations

  1. Zentrum Innere Medizin, Abt. Kardiologie und Pneumologie, Georg-August-Universität Göttingen, Robert-Koch-Straße 40, Göttingen, D-37075, Germany

    Gerd Hasenfuss

  2. Section of Molecular and Cellular Cardiology, The Johns Hopkins University, 844 Ross Building, Baltimore, MD, 21205, USA

    Eduardo Marbán M.D., Ph.D. (Professor of Medicine and Physiology) (Professor of Medicine and Physiology)

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© 2000 Springer-Verlag Berlin Heidelberg

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Schmidt, A.G., Kranias, E.G. (2000). Genetic approaches to elucidate the regulatory role of phospholamban in the heart. In: Hasenfuss, G., Marbán, E. (eds) Molecular Approaches to Heart Failure Therapy. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57710-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-57710-9_4

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63332-4

  • Online ISBN: 978-3-642-57710-9

  • eBook Packages: Springer Book Archive

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