Abstract
Cardiac contraction is performed by the ATP-consuming cyclic interaction of the “molecular motor” myosin with the actin filament. The myosin heavy chain (MHC) contains the actin and ATP binding sites. Two different MHC genes (α and β) with distinct biochemical features are expressed in the human atrium, but only the β-MHC is expressed in the ventricle. Mutations in genes coding for ventricular myosin subunits are associated with hypertrophic cardiomyopathy. Motor function could be tuned by essential myosin light chain (MLC-1) isoforms. Expression of the atrial MLC-1 isoform in the hypertrophied human ventricle increases cross-bridge cycling kinetics and contractility. It is suggested that MLC-1 acts as a MHC/actin tether. Weakening of this tether increased myosin function.
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Morano, I. (2000). Modulation of cardiac function by essential myosin light chains in health and disease. In: Hasenfuss, G., Marbán, E. (eds) Molecular Approaches to Heart Failure Therapy. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57710-9_19
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DOI: https://doi.org/10.1007/978-3-642-57710-9_19
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