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Molecular Approaches to Heart Failure Therapy pp 126–143Cite as

Myocardial-specific gene delivery

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Abstract

Somatic gene therapy represents a promising approach for the treatment of inherited and acquired heart diseases. In contrast to final stadium cancer or rare inherited diseases, established pharmacological, catheter-based or surgical alternatives for treatment of cardiac disorders frequently exist. Therefore, the safety of the vector system and its application requires careful consideration in cardiac gene therapy approaches. An ideal vector system should be immunologically tolerated, allow gene expression specifically in the myocardium, and should be administered with high efficacy as specific as possible.

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Author information

Authors and Affiliations

  1. Medizinische Klinik II, Medizinische Universität zu Lübeck, Lübeck, Germany

    W.-M. Franz, O. J. Müller & H. A. Katus

  2. Medizinische Klinik I, Klinikum Groβhadern der LMU, München, Germany

    G. von Degenfeld, G. Steinbeck & P. Boekstegers

Authors
  1. W.-M. Franz
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  2. O. J. Müller
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  3. H. A. Katus
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  4. G. von Degenfeld
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  5. G. Steinbeck
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  6. P. Boekstegers
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Editors and Affiliations

  1. Zentrum Innere Medizin, Abt. Kardiologie und Pneumologie, Georg-August-Universität Göttingen, Robert-Koch-Straße 40, Göttingen, D-37075, Germany

    Gerd Hasenfuss

  2. Section of Molecular and Cellular Cardiology, The Johns Hopkins University, 844 Ross Building, Baltimore, MD, 21205, USA

    Eduardo Marbán M.D., Ph.D. (Professor of Medicine and Physiology) (Professor of Medicine and Physiology)

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© 2000 Springer-Verlag Berlin Heidelberg

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Franz, WM., Müller, O.J., Katus, H.A., von Degenfeld, G., Steinbeck, G., Boekstegers, P. (2000). Myocardial-specific gene delivery. In: Hasenfuss, G., Marbán, E. (eds) Molecular Approaches to Heart Failure Therapy. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57710-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-57710-9_11

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63332-4

  • Online ISBN: 978-3-642-57710-9

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