Skip to main content
SpringerLink
Log in

Bienen- und Wespengiftallergie: Hyposensibilisierung seit 50 Jahren und noch mehr!

  • Chapter
Fortschritte der Dermatologie

  • 57 Accesses

Zusammenfassung

Durch Insektenstich ausgelöste Allgemeinreaktionen mit den Symptomen der Soforttypallergie (Anaphylaxie) sind häufig, sie betreffen 0,8-5% der Bevölkerung [29]. Sie werden in Mitteleuropa meist durch Honigbienen (Apis mellifera; im Folgenden Biene) oder bestimmte Faltenwespen (Vespula vulgaris, Vespula germanica; im Folgenden Wespe) verursacht, selten durch Stiche anderer Insekten. Anaphylaxie durch einen oder wenige Stiche ist nahezu immer IgE-vermittelt. Der Schweregrad solcher Reaktionen ist unterschiedlich, die Symptome reichen von ausschließlichen Hauterscheinungen über respiratorische, kardiovaskuläre oder gastrointestinale Beschwerden bis zum Vollbild des anaphylaktischen Schocks. Jährlich werden in Deutschland 10–40 Todesfälle durch solche Reaktionen erfasst. Die tatsächliche Häufigkeit dürfte aber wesentlich größer sein, da an Hymenopterengiftanaphylaxie als Todesursache zu selten gedacht wird.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bauer CP (1986) Stichprovokation zur Diagnostik von Insektengift-Allergien? Allergologie 9:14

    Google Scholar 

  2. Benson RL, Semenov H (1930) Allergy in its relation to bee sting. J Allergy 1:105–116

    Article  Google Scholar 

  3. Blaauw PJ, Smithuis OLM, Elbers ARW (1996) The value of an in-hospital insect sting challenge as a criterion for application or omission of venom immunotherapy J Allergy Clin Immunol 98:39–47

    Article  PubMed  CAS  Google Scholar 

  4. Bousquet J, Lockey RF, Mailing HJ (1998) WHO position paper. Allergen immunotherapy: therapeutic vaccines for allergic disease. Allergy 53 (Suppl 44):6–42

    Google Scholar 

  5. Brehler R, Wolf H, Kütting B, Schnitker J, Luger T (2000) Safety of a twoday ultrarush insect venom immunotherapy protocol in comparison with protocols of longer duration and involving a larger number of injections. J Allergy Clin Immunol 105:1231–1235

    Article  PubMed  CAS  Google Scholar 

  6. Bresser H, Sandner C, Rakoski J (1995) Insektenstichnotfälle in München 1992. Allergo J 4:373–376

    Google Scholar 

  7. Committee on Insects (1998) Position statement: The discontinuation of Hymenoptera venom immunotherapy. J Allergy Clin Immunol 101:573–575

    Article  Google Scholar 

  8. Forster KA (1960) Allergie gegen Wespengift. Münch Med Wochenschr 102:2043

    Google Scholar 

  9. Franken HH, Dubois AEJ, Minkema HJ, van der Heide S, de Monchy JGR (1994) Lack or reproducibility of a single negative sting challenge response in the assessment of anaphylactic risk in patients with suspected yellow jacket hypersensitivity. J Allergy Clin Immunol 93:431–436

    Article  PubMed  CAS  Google Scholar 

  10. Goldberg A, Confino-Cohen R (1997) Timing of venom skin tests and IgE determinations after insect sting anaphylaxis. J Allergy Clin Immunol 100:182–184

    Article  PubMed  CAS  Google Scholar 

  11. Goldberg A, Confino-Cohen R (2001) Maintenance venom immunotherapy administered at 3-month intervals is both safe and efficacious. J Allergy Clin Immunol 107:902–906

    Article  PubMed  CAS  Google Scholar 

  12. Golden DBK, Langlois J, Valentine MD, Kagey-Sobotka A, Lichtenstein ML (1981) Treatment failures with whole-body extract therapy of insect sting allergy. J Amer Med Assoc 246:2460–2463

    Article  CAS  Google Scholar 

  13. Höxtermann S, Auer T, Altmeyer P (1995) Zelluläre In-vitro-Diagnostik mittels CAST-ELISA. Leukotriennachweis bei Wespengift-Allergie. Allergologie 18:291–297

    Google Scholar 

  14. Hunt KJ, Valentine MD, Sobotka AK, Benton AW, Amodio FJ, Lichtenstein LM (1978) A controlled trial of immunotherapy in insect hypersensitivity. N Engl J Med 299:157–161

    Article  PubMed  CAS  Google Scholar 

  15. Insect Allergy Committee of the American Academy of Allergy (1965) Insect sting allergy. Questionnaire study of 2606 cases. J Amer Med Assoc 193:109–114

    Google Scholar 

  16. Jeep S, Paul M, Müller UR, Kunkel G (1996) Honeybee venom allergy: immunoblot studies in allergic patients after immunotherapy and before sting challenge. Allergy 51:540–546

    PubMed  CAS  Google Scholar 

  17. Jung K, Lehmann B, Linse R (1999) Die Bedeutung des AlaSTAT-AlaBLOT Immunoblot für die Diagnose von Insektengiftallergien. Allergologie 22:421–427

    Google Scholar 

  18. Kämmerer H (1941) Desensibilisierung gegen Bienengift. Münch Med Wochenschr 88:939

    Google Scholar 

  19. Kumar M, Behera AK, Hu J, Lockey RF, Mohapatra SS (2001) IFN-γ and IL-12 plasmid DNAs as vaccine adjuvant in a murine model of grass allergy. J Allergy Clin Immunol 108:402–408

    Article  PubMed  CAS  Google Scholar 

  20. Lichtenstein LM, Valentine MD, Sobotka AK (1974) A case for venom treatment in anaphylactic sensitivity to Hymenoptera sting. N Engl J Med 290:1223–1227

    Article  PubMed  CAS  Google Scholar 

  21. Light WC (2001) Insect sting fatality 9 years after venom treatment. J Allergy Clin Immunol 107:925

    Article  PubMed  CAS  Google Scholar 

  22. Light WC, Reisman RE, Shimizu M, Arbesman CE (1977) Clinical application of measurements of serum levels of bee venom-specific IgE and IgG. J Allergy Clin Immunol 59:247–253

    Article  PubMed  CAS  Google Scholar 

  23. Lotter G (1939) Sensibilisierung für Bienengift durch Typhus-Antitoxin und Desensibilisierung mit Forapin. Münch Med Wochenschr 86:330–331

    Google Scholar 

  24. Loveless MH, Fackler WR (1956) Wasp venom allergy and immunity. Ann Allergy 14:347–366

    PubMed  Google Scholar 

  25. Ludolph-Hauser D, Ruëff F, Fries C, Schöpf P, Przybilla B (2001) Constitutively raised serum concentrations of mast cell tryptase and severe anaphylactic reactions to Hymenoptera stings. Lancet 357:261–262

    Article  Google Scholar 

  26. Mosbech H, Müller U (2000) Side-effects of insect venom immunotherapy: results from an EAACI multicenter study. Allergy 55:1005–1010

    Article  PubMed  CAS  Google Scholar 

  27. Müller UR (1988) Insektenstichallergie. Klinik, Diagnostik und Therapie. Fischer, Stuttgart

    Google Scholar 

  28. Müller U, Berchtold E, Helbling A (1991) Honeybee venom allergy: results of a sting challenge 1 year after stopping successful venom immunotherapy in 86 patients. J Allergy Clin Immunol 87:702–709

    Article  PubMed  Google Scholar 

  29. Müller U, Mosbech H (eds) (1993) Position paper: Immunotherapy with Hymenoptera venoms. Allergy 48 (Suppl 14):412–418

    Google Scholar 

  30. Noon L (1911) Prophylactic inoculation against hay fever. Lancet I:1572–1573

    Article  Google Scholar 

  31. Ollert M, Ring J (1999) Prognostische Bedeutung von Immunoblot-Untersuchungen bei Hymenopterengift-Allergie. Allergologie 22 (Suppl 2):S78–S79

    Google Scholar 

  32. Oude Elberink JNG, de Monchy JGR, Kors JW, van Doormaal JJ, Dubois AEJ (1997) Fatal anaphylaxis after a yellow jacket sting, despite venom immunotherapy, in two patients with mastocytosis. J Allergy Clin Immunol 99:153–154

    Article  Google Scholar 

  33. Przybilla B, Ring J, Galosi A, Geursen RG, Stickl A (1986) Bee venom immunoglobulin for prophylaxis of anaphylactic reactions during bee venom immunotherapy (rush hyposensitization). Immunol Allergy Practice 8:107–111

    Google Scholar 

  34. Przybilla B, Ring J, Grießhammer B (1989) Diagnostische Befunde bei Hymenopterengiftallergie. Zur Bedeutung von Anamnese, Hauttest und RAST. Allergologie 12:192–202

    Google Scholar 

  35. Przybilla B, Ring J, Grießhammer B, Braun-Falco O (1987) Schnellhyposensibilisierung mit Hymenopterengiften. Verträglichkeit und Therapieerfolg. Dtsch Med Wochenschr 112:416–424

    Article  PubMed  CAS  Google Scholar 

  36. Przybilla B, Ring J, Wielgosch J (1988) Der Basophilen-Histamin-Freisetzungstest als diagnostische Methode bei Hymenopterengift-Allergie. Hautarzt 39:662–670

    PubMed  CAS  Google Scholar 

  37. Ring J, Messmer K (1977) Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet I:466–469

    Article  Google Scholar 

  38. Ruëff F, Bollessen M, Przybilla B (1998) Efficacy and safety of honeybee venom (HBV) immunotherapy with an aqueous (AE) and an aluminium hydroxide adsorbed depot extract (DE). Allergy 43 (Suppl 43):208

    Google Scholar 

  39. Ruëff F, Przybilla B, Fuchs T, Gall H, Rakoski J, Stolz W, Vieluf D (2000) Diagnose und Therapie der Bienen-und Wespengiftallergie. Positionspapier der Deutschen Gesellschaft für Allergologie und klinische Immunologie. Allergo J 9:458–472

    Google Scholar 

  40. Ruëff F, Przybilla B, Müller U, Mosbech H (1996) The sting challenge test in Hymenoptera venom allergy. Allergy 51:216–225

    PubMed  Google Scholar 

  41. Ruëff F, Wenderoth A, Przybilla B (2002) Patients still reacting to a sting challenge while on conventional Hymenoptera venom immunotherapy are protected by increased venom doses. J Allergy Clin Immunol, in press

    Google Scholar 

  42. Sainte-Laudy J, Sabbah A, Drouet M, Lauret MG, Loiry M (2000) Diagnosis of venom allergy by flow cytometry. Correlation with clinical history, skin tests, specific IgE, histamine and leukotriene C4 release. Clin Exper Allergy 30:1166–1171

    Article  CAS  Google Scholar 

  43. Torsney PJ (1973) Treatment failure: insect desensitization. Case reports of fatalities. J Allergy Clin Immunol 52:303–306

    Article  PubMed  CAS  Google Scholar 

  44. Vetter RS (2000) Wasp or hippopotamus? J Allergy Clin Immunol 106:196

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. B. Przybilla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Franziska Ruëff
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München

    Birger Konz  & Gerd Plewig  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Przybilla, B., Ruëff, F. (2002). Bienen- und Wespengiftallergie: Hyposensibilisierung seit 50 Jahren und noch mehr!. In: Konz, B., Plewig, G. (eds) Fortschritte der Dermatologie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57539-6_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57539-6_19

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63295-2

  • Online ISBN: 978-3-642-57539-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation