Skip to main content
SpringerLink
Log in

Plaquedarstellung und -charakterisierung

  • Chapter
Kardiovaskuläre Magnetresonanztomographie

  • 64 Accesses

Zusammenfassung

Die Diagnostik der Arteriosklerose basiert weitgehend auf der Erkennung von flusslimitierenden Stenosen. Ca. 60 bis 70% der akuten Koronarsyndrome (instabile Angina pectoris) werden jedoch von Stenosen mit einer Einengung von <50% verursacht [1, 15]. Die invasive Koronarangiographie erlaubt die Erfassung von Stenosen, liefert jedoch nur geringe Informationen über Grösse und Ausmaß von arteriosklerotischen Plaques. Dabei scheint nicht nur das Plaquevolumen, sondern auch die biochemische (biologische) Zusammensetzung von Plaques maßgeblich deren Stabilität und Verletzbarkeit zu beeinflussen und gilt daher als wichtiger Indikator für das Risiko einer Plaqueruptur und der damit verbundenen Bildung lumenverengender Thromben zur Arteriosklerose.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Ambrose JA, Tannenbaum MA, Alexopoulos D, Hjemdahl-Monsen CE, Leavy J, Weiss M, Borrico S, Gorlin R, Fuster V (1988) Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 12:56–62

    Article  PubMed  CAS  Google Scholar 

  2. Atalar E, Bottomley PA, Ocali O, Correia LC, Kelemen MD, Lima JA, Zerhouni EA (1996) High resolution intravascular MRI and MRS by using a catheter receiver coil. Magn Reson Med. 36:596–605

    Article  PubMed  CAS  Google Scholar 

  3. Altbach MI, Mattingly MA, Brown MF, Gmitro AF (1991) Magnetic resonance imaging of lipid deposits in human atheroma via a stimulatedecho diffusion-weighted technique. Magn Reson Med 20:319–326

    Article  PubMed  CAS  Google Scholar 

  4. Botnar RM, Stuber M, Kissinger KV, Kim WY, Spuentrup E, Manning WJ (2000) Noninvasive Coronary Vessel Wall and Plaque Imaging With Magnetic Resonance Imaging. Circulation 102: 2582–2587

    Article  PubMed  CAS  Google Scholar 

  5. Botnar RM, Stuber M, Kissinger KV, Kim WY (2000) Towards higher resolution non-invasive MR coronary vessel wall imaging. Circulation (Suppl) 2232

    Google Scholar 

  6. Botnar RM, Perez AS, Manning WJ, Johnstone MT (2000) In-vivo Imaging of Atherosclerotic Plaque and Thrombus after Plaque Rupture using MRI. SCMR, 3rd Annual Meeting. Atlanta: Society for Cardiovascular Magnetic Resonance, Atlanta

    Google Scholar 

  7. Falk E, Shah PK, Fuster V (1995) Coronary plaque disruption. Circulation. 92:657–671

    Article  PubMed  CAS  Google Scholar 

  8. Fayad ZA, Fallon JT, Shinnar M, Wehrli S, Dansky HM, Poon M, Badimon JJ, Charlton SA, Fisher EA, Breslow JL, Fuster V (1998) Noninvasive In vivo high-resolution magnetic resonance imaging of atherosclerotic lesions in genetically engineered mice. Circulation 98:1541–1547

    Article  PubMed  CAS  Google Scholar 

  9. Fayad ZA, Nahar T, Fallon JT, Goldman M, Aguinaldo JG, Badimon JJ, Shinnar M, Chesebro JH, Fuster V (2000) In vivo magnetic resonance evaluation of atherosclerotic plaques in the human thoracic aorta: a comparison with transesophageal echocardiography. Circulation 101: 2503–2509

    Article  PubMed  CAS  Google Scholar 

  10. Fayad ZA, Fuster V, Fallon JT, Jayasundera T, Worthley SG, Helft G, Aguinaldo JG, Badimon JJ, Sharma SK (2000) Noninvasive in vivo human coronary artery lumen and wall imaging using black-blood magnetic resonance imaging. Circulation 102:506–510

    Article  PubMed  CAS  Google Scholar 

  11. Gold GE, Pauly JM, Glover GH, Moretto JC, Macovski A, Herfkens RJ (1993) Characterization of atherosclerosis with a 1.5-T imaging system. J Magn Reson Imaging 3:399–407

    Article  PubMed  CAS  Google Scholar 

  12. Hatsukami TS, Ross R, Polissar NL, Yuan C (2000) Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation 102:959–964

    Article  PubMed  CAS  Google Scholar 

  13. Hurst GC, Hua J, Duerk JL, Cohen AM (1992) Intravascular (catheter) NMR receiver probe: preliminary design analysis and application to canine iliofemoral imaging. Magn Reson Med 24:343–357

    Article  PubMed  CAS  Google Scholar 

  14. Lauffer RB, Graham PB, Lahti KM, Nair S, Caravan P, Kolodziej A (2000) Direct clot detection with MRI using a novel fibrin-targeted Gadolinium agent. Circulation (Suppl) 1831

    Google Scholar 

  15. Little WC, Constantinescu M, Applegate RJ, Kutcher MA, Burrows MT, Kahl FR, Santamore WP (1988) Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation 78:1157–1166

    Article  PubMed  CAS  Google Scholar 

  16. Maki JH, Wilson GJ, Lauffer RB, Weisskoff RM, Yuan C (2000) Vessel wall enhancement with MS-325 facilitates plaque detection and characterization. Circulation (Suppl) 1832

    Google Scholar 

  17. Martin AJ, Plewes DB, Henkelman RM (1992) MR imaging of blood vessels with an intravascular coil. J Magn Reson Imaging 2:421–429

    Article  PubMed  CAS  Google Scholar 

  18. McConnell MV, Aikawa M, Maier SE, Ganz P, Libby P, Lee RT (1999) MRI of rabbit atherosclerosis in response to dietary cholesterol lowering. Arterioscler Thromb Vasc Biol 19:1956–1959

    Article  PubMed  CAS  Google Scholar 

  19. Meyer CH, Bob BS, Macovski A, Nishimura DG (1998) Coronary vessel wall imaging. In: ISMRM, 6th Annual Meeting. Sydney: International Society for Magnetic Resonance in Medicine, Berkeley, California, USA, p 15

    Google Scholar 

  20. Quick HH, Ladd ME, Zimmermann-Paul GG, Erhart P, Hofmann E, von Schulthess GK, Debatin JF (1999) Single-loop coil concepts for intravascular magnetic resonance imaging. Magn Reson Med 41:751–758

    Article  PubMed  CAS  Google Scholar 

  21. Raynaud JS, Bridal SL, Toussaint JF, Fornes P, Lebon V, Berger G, Leroy-Willig A (1998) Characterization of atherosclerotic plaque components by high resolution quantitative MR and US imaging. J Magn Reson Imaging 8:622–629

    Article  PubMed  CAS  Google Scholar 

  22. Rogers WJ, Prichard JW, Hu YL, Olson PR, Benckart DH, Kramer CM, Vido DA, Reichek N (2000) Characterization of signal properties in atherosclerotic plaque components by intravascular MRI. Arterioscler Thromb Vasc Biol 20: 1824–1830

    Article  PubMed  CAS  Google Scholar 

  23. Schmitz SA, Coupland SE, Gust R, Winterhalter S, Wagner S, Kresse M, Semmler W, Wolf KJ (2000) Superparamagnetic iron oxide-enhanced MRI of atherosclerotic plaques in Watanabe hereditable hyperlipidemic rabbits. Invest Radiol 35:460–471

    Article  PubMed  CAS  Google Scholar 

  24. Shinnar M, Fallon JT, Wehrli S, Levin M, Dalmacy D, Fayad ZA, Badimon JJ, Harrington M, Harrington E, Fuster V (1999) The diagnostic accuracy of ex vivo MRI for human atherosclerotic plaque characterization. Arterioscler Thromb Vasc Biol 19:2756–2761

    Article  PubMed  CAS  Google Scholar 

  25. Toussaint JF, Southern JF, Fuster V, Kantor HL (1995) T2-weighted contrast for NMR characterization of human atherosclerosis. Arterioscler Thromb Vasc Biol 15:1533–1542

    PubMed  CAS  Google Scholar 

  26. Toussaint JF, LaMuraglia GM, Southern JF, Fuster V, Kantor HL (1996) Magnetic resonance images lipid, fibrous, calcified, hemorrhagic, and thrombotic components of human atherosclerosis in vivo. Circulation 94:932–938

    Article  PubMed  CAS  Google Scholar 

  27. Vinitski S, Consigny PM, Shapiro MJ, Janes N, Smullens SN, Rifkin MD (1991) Magnetic resonance chemical shift imaging and spectroscopy of atherosclerotic plaque. Invest Radiol 26:703–714

    Article  PubMed  CAS  Google Scholar 

  28. Worthley SG, Helft G, Fuster V, Zaman AG, Fayad ZA, Fallon JT, Badimon JJ (2000) Serial in vivo MRI documents arterial remodeling in experimental atherosclerosis. Circulation 101: 586–589

    Article  PubMed  CAS  Google Scholar 

  29. Worthley SG, Helft G, Fuster V, Fayad ZA, Rodriguez OJ, Zaman AG, Fallon JT, Badimon JJ (2000) Noninvasive in vivo magnetic resonance imaging of experimental coronary artery lesions in a porcine model. Circulation 101:2956–2961

    Article  PubMed  CAS  Google Scholar 

  30. Yuan C, Skinner MP, Kaneko E, Mitsumori LM, Hayes CE, Raines EW, Nelson JA, Ross R (1996) Magnetic resonance imaging to study lesions of atherosclerosis in the hyperlipidemic rabbit aorta. Magn Reson Imaging 14:93–102

    Article  PubMed  CAS  Google Scholar 

  31. Yuan C, Beach KW, Smith LH, Jr., Hatsukami TS (1998) Measurement of atherosclerotic carotid plaque size in vivo using high resolution magnetic resonance imaging. Circulation 98: 2666–2671

    Article  PubMed  CAS  Google Scholar 

  32. Zimmermann-Paul GG, Quick HH, Vogt P, von Schulthess GK, Kling D, Debatin JF (1999) High-resolution intravascular magnetic resonance imaging: monitoring of plaque formation in heritable hyperlipidemic rabbits. Circulation 99:1054–1061

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. René Botnar
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Deutsches Herzzentrum Berlin, Kardiologie — CMR, Augustenburger Platz 1, 13353, Berlin, Germany

    Eike Nagel

  2. Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, Niederlande

    Albert C. van Rossum

  3. Deutsches Herzzentrum Berlin, Kardiologie/Innere Medizin, Augustenburger Platz 1, 13353, Berlin, Germany

    Eckart Fleck

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Botnar, R. (2002). Plaquedarstellung und -charakterisierung. In: Nagel, E., van Rossum, A.C., Fleck, E. (eds) Kardiovaskuläre Magnetresonanztomographie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57535-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57535-8_21

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63291-4

  • Online ISBN: 978-3-642-57535-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation