Skip to main content

RCT-Pestwurzextrakt Ze 339 vs. Cetirizin bei allergischer Rhinitis

  • Conference paper
  • 86 Accesses

Zusammenfassung

Allergische Rhinitis ist eine hypersensitive Reaktion der nasalen Mukosa auf Allergene; die Konjunktiven und der Rachenbereich reagieren häufig ebenfalls. Im Vordergrund stehen entzündliche Reaktionen mit den typischen Symptomen wie verstopfte und laufende Nase, Niesen, Jucken in Nase und Rachen, Rötung und Jucken der Augen sowie Tränenfluss. Die Patienten sind in ihren Tagesaktivitäten und dem Konzentrationsvermögen alteriert, der Schlaf ist gestört, d.h. die Lebensqualität ist teilweise beträchtlich eingeschränkt [2, 4, 6].

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bickel D, Röder T, Beestmann HJ, Brune K (1994) Identification and characterization of inhibitors of peptido-leukotriene-synthesis from petasites hybridus. Planta Med 60:318–322

    Article  PubMed  CAS  Google Scholar 

  2. Bousquet J, Duchateau J, Pignat JC, Fayol C, Marquis P, Mariz S, Ware JE, Valentin B, Burtin B (1996) Improvement of quality of life by treatment with cetirizine in patients with perennial allergic rhinitis as determined by a French version of the SF-36 questionnaire. J Allergy Clin Immunol 98:309–316

    Article  PubMed  CAS  Google Scholar 

  3. Brune K, Bickel D, Peskar BA (1993) Gastro-protective effects by extracts of petasites hybridus: The role of inhibition of peptido-leukotriene synthesis. Planta Med 59:494–496

    Article  PubMed  CAS  Google Scholar 

  4. Craig TJ, Teets S, Lehmann EB, Chinchili VM, Zwillich C (1998) Decreasing nasal congestion may improve quality of life for patients with rhinitis. J Allergy Clin Immunol 101:633–637

    Article  PubMed  CAS  Google Scholar 

  5. Day JH, Briscoe MP, Clark RH, Ellis AK, Gerwais P (1997) Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis. Ann Allergy Asthma Immunol 79:163–172

    Article  PubMed  CAS  Google Scholar 

  6. Internat. Rhinitis Management Group (1994) Definition and classification of rhinitis (Consensus). Allergy (suppl 19):5–34

    Google Scholar 

  7. Kay GC, Berman B, Mockoviak SH, Morris CE, Reeves D, Starbuck V, Sukenik E, Harris AG (1997) Initial and steady-state effects of dephenhydramine and loratadine on sedation, cognition, mood, and psychomotor performance. Arch Int Med 157: 2350–2356

    Article  CAS  Google Scholar 

  8. Käufeier R, Thomet OAR, Simon HU, Meier B, Brattström A (2000) Der Pestwurzextrakt Ze 339-Wirkprinzipien und klinische Pharmakologie. In: Rietbrock N (Hrsg) Phytopharmaka VI-Forschung und klinische Anwendung. Steinkopff, Darmstadt, S 237–246

    Google Scholar 

  9. Scheidegger C, Dahinden C, Wiesmann U (1998) Effcts of extract and of individual components from petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. Pharmaceut Acta Helvetiae 72:376–378

    CAS  Google Scholar 

  10. Simons FER, McMillan JL, Simons KJ (1990) A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: Suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects. J Allergy Clin Immunolo 86:540–547

    Article  CAS  Google Scholar 

  11. Thomet OAR, Wiesmann UW, Schapowal A, Bizer C, Simon HU (2001) Role of peta-sin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. Biochem Pharmacol 61:1041–1047

    Article  PubMed  CAS  Google Scholar 

  12. Thomet OAR, Wiesmann UN, Blaser K, Simon UW (2001) Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils. Clin Experiment Allergy 31:1310–1320

    Article  CAS  Google Scholar 

  13. Thomet OAR, Schapowal A, Isabelle Heinisch VWM, Wiesmann UN, Simon HU (submitted) An extract of Petasites hybridus as treatment for allergic rhinitis: An open clinical trial

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Brattström, A., Schapowal, A. (2002). RCT-Pestwurzextrakt Ze 339 vs. Cetirizin bei allergischer Rhinitis. In: Schulz, V., Rietbrock, N., Roots, I., Loew, D. (eds) Phytopharmaka VII. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57528-0_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57528-0_19

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63286-0

  • Online ISBN: 978-3-642-57528-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics