Zusammenfassung
Halluzinogen wirkende Substanzen können in vier Gruppen eingeteilt werden: in die Indolalkylamine mit dem Grundgerüst der Aminosäure Tryptophan (Vorstufe von Tryptamin und Serotonin), die Phenylalkylamine mit dem Grundgerüst der Aminosäure Tyrosin (Vorstufe von Dopamin, Noradrenalin und Adrenalin) sowie bei einer umfassenderen Definition auch Anticholinergika und NMDA-Glutamatrezeptor-Antagonisten [15]. Zu den halluzinogen wirkenden Tryptamin-Abkömmlingen sind N,N-Dimethyltryptamin (DMT), (+)Lyserg-säurediethylamid ((+)LSD) und die β-Carboline Harmalin und Harmin zu rechnen. Zu den Phenylalkylaminen gehören Meskalin, Amphetamin und seine Derivate wie z.B. Ecstasy. Beispiele für Anticholinergika sind Atropin und Scopolamin und solche für nicht-kompetitiv wirkende NMDA-Rezeptor-Antagonisten Phencyclidin (PCP), Ketamin, Dextromethorphan und Dizocilpin (MK 801).
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Refernces
Bear D (1991) Neurological perspectives on aggressive behavior. J Neuropsychiatry Clin Neurosci 3: S3–S8
Carlsson A (2000) Network interactions in schizophrenia-therapeutic implications. Brain Res Rev 31: 342–349
Dierks T, Linden DEJ, Jandl M, Formisano E, Goebel R, Laufermann H, Singer W (1999) Activation of Heschl’s gyrus during auditory halluzinations. Neuron 22: 615–621
Sharp FR, Tomitaka M, Bernaudin M, Tomitaka S (2001) Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia? Trends in Neurosciences 24: 330–334
Ergene E, Schoener E (1993) Effects of harmane (1-methyl-β-carboline) on neurons in the nucleus accumbens of the rat. Pharmacol Biochem Behav 44: 951–957
Fekkes D, Bode WT (1993) Occurrence and partition of the β-carboline norharman in rat organs. Life Sci 52: 2045–2054
Lichtenberg-Kraag B, Klinker JF, Mühlbauer E, Rommelspacher H (1997) The natural β-car-bolines facilitate inositol phosphate accumulation by activating small G-proteins in human neuroblastoma cells (SH-SY5Y). Neuropharmacology 36: 1771–1778
Lin GC, Glennon, RA (eds) (1994) Halluzinogene: an update. NIDA Res Monographs 146, U.S. Department of health and human services, Rockville, MD
Matsubara K, Collins MA, Akane A, Ikebuchi J, Neafsey EJ, Kagawa M, Shiono H (1993) Potential bioactivated neurotoxicants, N-methylated β-carbolinium ions are present in human brain. Brain Res 610: 90–96
McGuire PK, Silbersweig DA, Murray RM, David AS, Frackowiak RSJ, Frith CD (1996) Functional anatomy of unner speech and auditory verbal imagery. Psychol Med 26: 29–38
Morris JS, Ohman A, Dolan RJ (1998) Conscious and unconscious emotional learning in the human amygdala. Nature 393: 467–470
Naranjo C (1979) Psychotropic properties of the harmala alkaloids. In: Efron DH, Holmstedt B, Kline NS (eds) Ethnopharmacologic search for psychoactive drugs. Raven Press, New York, pp 385–391
Olney JW, Newcomer JW, Faber NB (1999) NMDA receptor hypofunction model of schizophrenia. J Psychiat Res 33: 523–533
Pawlik M, Kaulen P, Baumgarten HG, Rommelspacher H (1990) Quantitative autoradiography of [3H] norharman ([3H] β-carboline) binding sites in the rat brain. J Chem Neuroanatomy 3: 9–24
Rommelspacher H (1999) Halluzinogene. In: Gastpar K, Mann H, Rommelspacher H (Hrsg) Lehrbuch der Suchterkrankungen. Thieme, Stuttgart, New York, S 221–227
Rommelspacher H, Schmidt LG, May T (1991) Plasma norharman (beta-carboline) levels are elevated in chronic alcoholics. Alcoholism — Clin Exp Res 15: 553–559
Sällström Baum S, Hill R, Rommelspacher H (1995) Norharman-induced changes of extracellular concentrations of dopamine in the nucleus accumbens of rats. Life Sci 56: 1715–1720
Sällström Baum S, Hill R, Rommelspacher H (1996) Harman-induced changes of extracellular concentrations of neurotransmitters in the nucleus accumbens of rats. Eur J Pharmacol 314: 75–82
Spies CD, Rommelspacher H, Winkler T, Müller C, Brummer G, Funk T, Berger G, Fell M, Blum S, Specht M, Hannemann L, Schaffartzik W (1996) b-carbolines in chronic alcoholics following trauma. Addiction Biol 1: 93–103
Spies CD, Morciniec P, Lenzenhuber E, Müller C, Marks C, Helling K, Runkel N, Berger G, Blum S, Rommelspacher H (1998) β-carbolines in alcohol-dependent intensive care patients during prophylactics and therapy of alcohol withdrawal syndrome. Addiction Biol 3: 281–294
Stell JM, Ryan, JM (1996) Ecstasy and neurodegeneration. Gamma-hydroxybutyrate is a new recreational drug that may lead to loss of consciousness. BMJ 313: 424
Tamminga C (1999) Glutamatergic aspects of schizophrenia. Br J Psychiat (suppl): 12–15
Thomas G, Bonner S, Gascoigne A (1997) Coma induced by abuse of gamma-hydroxybutyrate (GHB or liquid ecstasy): a case report. BMJ 314: 25–26
Wodarz N, Wiesbeck GA, Rommelspacher H, Riederer P, Böning J (1996) Excretion of beta-carbolines harman and norharman in 24-hour urine of chronic alcoholics during withdrawal and controlled abstinence. Alcohol Clin Exp Res 20: 706–710
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Rommelspacher, H., Schmidt, L.G., Spies, C. (2003). Psychiatrische Forschung an der Freien Universität Berlin ß-Carboline als körpereigene Halluzinogene. In: Hippius, H. (eds) Universitätskolloquien zur Schizophrenie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57417-7_11
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