Skip to main content

Psychiatrische Forschung an der Freien Universität Berlin ß-Carboline als körpereigene Halluzinogene

  • Chapter
Universitätskolloquien zur Schizophrenie

Zusammenfassung

Halluzinogen wirkende Substanzen können in vier Gruppen eingeteilt werden: in die Indolalkylamine mit dem Grundgerüst der Aminosäure Tryptophan (Vorstufe von Tryptamin und Serotonin), die Phenylalkylamine mit dem Grundgerüst der Aminosäure Tyrosin (Vorstufe von Dopamin, Noradrenalin und Adrenalin) sowie bei einer umfassenderen Definition auch Anticholinergika und NMDA-Glutamatrezeptor-Antagonisten [15]. Zu den halluzinogen wirkenden Tryptamin-Abkömmlingen sind N,N-Dimethyltryptamin (DMT), (+)Lyserg-säurediethylamid ((+)LSD) und die β-Carboline Harmalin und Harmin zu rechnen. Zu den Phenylalkylaminen gehören Meskalin, Amphetamin und seine Derivate wie z.B. Ecstasy. Beispiele für Anticholinergika sind Atropin und Scopolamin und solche für nicht-kompetitiv wirkende NMDA-Rezeptor-Antagonisten Phencyclidin (PCP), Ketamin, Dextromethorphan und Dizocilpin (MK 801).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 79.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Refernces

  1. Bear D (1991) Neurological perspectives on aggressive behavior. J Neuropsychiatry Clin Neurosci 3: S3–S8

    PubMed  CAS  Google Scholar 

  2. Carlsson A (2000) Network interactions in schizophrenia-therapeutic implications. Brain Res Rev 31: 342–349

    Article  PubMed  CAS  Google Scholar 

  3. Dierks T, Linden DEJ, Jandl M, Formisano E, Goebel R, Laufermann H, Singer W (1999) Activation of Heschl’s gyrus during auditory halluzinations. Neuron 22: 615–621

    Article  PubMed  CAS  Google Scholar 

  4. Sharp FR, Tomitaka M, Bernaudin M, Tomitaka S (2001) Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia? Trends in Neurosciences 24: 330–334

    Article  PubMed  CAS  Google Scholar 

  5. Ergene E, Schoener E (1993) Effects of harmane (1-methyl-β-carboline) on neurons in the nucleus accumbens of the rat. Pharmacol Biochem Behav 44: 951–957

    Article  PubMed  CAS  Google Scholar 

  6. Fekkes D, Bode WT (1993) Occurrence and partition of the β-carboline norharman in rat organs. Life Sci 52: 2045–2054

    Article  PubMed  CAS  Google Scholar 

  7. Lichtenberg-Kraag B, Klinker JF, Mühlbauer E, Rommelspacher H (1997) The natural β-car-bolines facilitate inositol phosphate accumulation by activating small G-proteins in human neuroblastoma cells (SH-SY5Y). Neuropharmacology 36: 1771–1778

    Article  PubMed  CAS  Google Scholar 

  8. Lin GC, Glennon, RA (eds) (1994) Halluzinogene: an update. NIDA Res Monographs 146, U.S. Department of health and human services, Rockville, MD

    Google Scholar 

  9. Matsubara K, Collins MA, Akane A, Ikebuchi J, Neafsey EJ, Kagawa M, Shiono H (1993) Potential bioactivated neurotoxicants, N-methylated β-carbolinium ions are present in human brain. Brain Res 610: 90–96

    Article  PubMed  CAS  Google Scholar 

  10. McGuire PK, Silbersweig DA, Murray RM, David AS, Frackowiak RSJ, Frith CD (1996) Functional anatomy of unner speech and auditory verbal imagery. Psychol Med 26: 29–38

    Article  PubMed  CAS  Google Scholar 

  11. Morris JS, Ohman A, Dolan RJ (1998) Conscious and unconscious emotional learning in the human amygdala. Nature 393: 467–470

    Article  PubMed  CAS  Google Scholar 

  12. Naranjo C (1979) Psychotropic properties of the harmala alkaloids. In: Efron DH, Holmstedt B, Kline NS (eds) Ethnopharmacologic search for psychoactive drugs. Raven Press, New York, pp 385–391

    Google Scholar 

  13. Olney JW, Newcomer JW, Faber NB (1999) NMDA receptor hypofunction model of schizophrenia. J Psychiat Res 33: 523–533

    Article  PubMed  CAS  Google Scholar 

  14. Pawlik M, Kaulen P, Baumgarten HG, Rommelspacher H (1990) Quantitative autoradiography of [3H] norharman ([3H] β-carboline) binding sites in the rat brain. J Chem Neuroanatomy 3: 9–24

    Google Scholar 

  15. Rommelspacher H (1999) Halluzinogene. In: Gastpar K, Mann H, Rommelspacher H (Hrsg) Lehrbuch der Suchterkrankungen. Thieme, Stuttgart, New York, S 221–227

    Google Scholar 

  16. Rommelspacher H, Schmidt LG, May T (1991) Plasma norharman (beta-carboline) levels are elevated in chronic alcoholics. Alcoholism — Clin Exp Res 15: 553–559

    Article  CAS  Google Scholar 

  17. Sällström Baum S, Hill R, Rommelspacher H (1995) Norharman-induced changes of extracellular concentrations of dopamine in the nucleus accumbens of rats. Life Sci 56: 1715–1720

    Article  Google Scholar 

  18. Sällström Baum S, Hill R, Rommelspacher H (1996) Harman-induced changes of extracellular concentrations of neurotransmitters in the nucleus accumbens of rats. Eur J Pharmacol 314: 75–82

    Article  Google Scholar 

  19. Spies CD, Rommelspacher H, Winkler T, Müller C, Brummer G, Funk T, Berger G, Fell M, Blum S, Specht M, Hannemann L, Schaffartzik W (1996) b-carbolines in chronic alcoholics following trauma. Addiction Biol 1: 93–103

    Google Scholar 

  20. Spies CD, Morciniec P, Lenzenhuber E, Müller C, Marks C, Helling K, Runkel N, Berger G, Blum S, Rommelspacher H (1998) β-carbolines in alcohol-dependent intensive care patients during prophylactics and therapy of alcohol withdrawal syndrome. Addiction Biol 3: 281–294

    Google Scholar 

  21. Stell JM, Ryan, JM (1996) Ecstasy and neurodegeneration. Gamma-hydroxybutyrate is a new recreational drug that may lead to loss of consciousness. BMJ 313: 424

    Article  PubMed  CAS  Google Scholar 

  22. Tamminga C (1999) Glutamatergic aspects of schizophrenia. Br J Psychiat (suppl): 12–15

    Google Scholar 

  23. Thomas G, Bonner S, Gascoigne A (1997) Coma induced by abuse of gamma-hydroxybutyrate (GHB or liquid ecstasy): a case report. BMJ 314: 25–26

    Google Scholar 

  24. Wodarz N, Wiesbeck GA, Rommelspacher H, Riederer P, Böning J (1996) Excretion of beta-carbolines harman and norharman in 24-hour urine of chronic alcoholics during withdrawal and controlled abstinence. Alcohol Clin Exp Res 20: 706–710

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rommelspacher, H., Schmidt, L.G., Spies, C. (2003). Psychiatrische Forschung an der Freien Universität Berlin ß-Carboline als körpereigene Halluzinogene. In: Hippius, H. (eds) Universitätskolloquien zur Schizophrenie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57417-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57417-7_11

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63263-1

  • Online ISBN: 978-3-642-57417-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics