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Emotionen: Neuropsychologische und funktionell bildgebende Korrelate

  • F. Schneider
  • U. Habel
Conference paper

Zusammenfassung

Emotionen, ein lange vernachlässigtes Forschungsfeld, rücken immer mehr in den Mittelpunkt des Interesses verschiedener Forschungsgruppen und werden zunehmend zum Ziel systematischer Untersuchungen mit funktionellen Bildge- bungsmethoden. Inzwischen sind eine Reihe von Untersuchungen zum emotionalen Erleben durchgeführt worden und zeigen ein breit gespanntes Netzwerk kortikaler und subkortikaler Korrelate auf [18, 42, 54, 63, 69].

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Literatur

  1. 1.
    Amunts K, Jäncke L, Mohlberg H, Steinmetz H, Zilles K (2000) Interhemispheric asymmetry of the human motor cortex related to handedness and gender. Neuropsychologia 38: 304–312PubMedCrossRefGoogle Scholar
  2. 2.
    Andia AM, Zisook S, Heaton RK, Jernigan T, Hesselink J (1995) Gender differences in schizophrenia. Journal Nerv Ment Dis 183: 522–528CrossRefGoogle Scholar
  3. 3.
    Baare WFC, Hulshoff HE, Hijman R, Mali WPTh, Viergever MA, Kahn R (1999) Volumetric analysis of frontal lobe regions in schizophrenia: Relation to cognitive function and symptomatology. Biol Psychiatry 45: 1597–1605PubMedCrossRefGoogle Scholar
  4. 4.
    Bogerts B (1997) The temporolimbic system theory of positive schizophrenic symptoms. Schizophr Bull 23: 423–435PubMedCrossRefGoogle Scholar
  5. 5.
    Breiter HC, Etcoff NL, Whalen PJ, Kennedy WA, Rauch SL, Buckner RL, Strauss MM, Hyman SE, Rosen BR (1996) Response and habituation of the human amygdala during visual processing of facial expression. Neuron 17: 875–887PubMedCrossRefGoogle Scholar
  6. 6.
    Bryant NL, Buchanan RW, Vladar K, Breier A, Rothman M (1999) Gender differences in temporal lobe structures of patients with schizophrenia: A volumetric MRI study. Am J Psychiatry 156: 603–609PubMedGoogle Scholar
  7. 7.
    Büchel C, Morris J, Dolan RJ, Friston KJ (1998) Brain systems mediating aversive conditioning: An event-related fMRI study. Neuron 20: 947–957PubMedCrossRefGoogle Scholar
  8. 8.
    Cannon TD, van Erp TG, Huttunen M, Lonnqvist J, Salonen O, Valanne L, Poutanen VP, Standertskjold-Nordenstam CG, Gur RE, Yan M (1998) Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls. Arch Gen Psychiatry 55: 1084–1091PubMedCrossRefGoogle Scholar
  9. 9.
    Coffey CE, Lücke JF, Saxton JA, Ratcliff G, Unitas LJ, Billig B, Bryan RN (1998) Sex differences in brain aging: A quantitative magnetic resonance imaging study. Arch Neurol 55: 169–179PubMedCrossRefGoogle Scholar
  10. 10.
    Cowell PE, Kostianovsky DJ, Gur RC, Turetsky BI, Gur RE (1996) Sex differences in neu-roanatomical and clinical correlations in schizophrenia. Am J Psychiatry 153: 799–805PubMedGoogle Scholar
  11. 11.
    Erwin RJ, Gur RC, Gur RE, Skolnick B, Mawhinney-Hee M, Smailis J (1992) Facial emotion discrimination: I. Task construktion and behavioral findings in normal subjects. Psychiatry Res 42: 231–240PubMedCrossRefGoogle Scholar
  12. 12.
    Falkai P, Bogerts B, Schneider T, Greve B, Pfeiffer U, Pilz K, Gonsiorzcyk C, Majtenyi C, Ovary I (1995) Disturbed planum temporale asymmetry in schizophrenia. A quantitative post-mortem study. Schizophr Res 14: 161–176PubMedCrossRefGoogle Scholar
  13. 13.
    Frederikse M, Lu A, Aylward E, Barta P, Sharma T, Pearlson G (2000) Sex differences in inferior parietal lobule volume in schizophrenia. Am J Psychiatry 157: 422–427PubMedCrossRefGoogle Scholar
  14. 14.
    Gaebel W, Wölwer W (1996) Affektstörungen schizophrener Kranker. Stuttgart: KohlhammerGoogle Scholar
  15. 15.
    Garavan H, Pendergrass JC, Ross TJ, Stein EA, Risinger RC (2001) Amygdala response to both positively and negatively valenced stimuli. Neuroreport 12: 2779–2783PubMedCrossRefGoogle Scholar
  16. 16.
    George MS, Ketter TA, Gill DS, Haxby JV, Ungerleider LG, Herscovitch P, Post RM (1993) Brain regions involved in recognizing facial emotion or identity: An oxygen-15 PET study. J Neuropsychiatry Clin Neurosci 5: 384–394PubMedGoogle Scholar
  17. 17.
    George MS, Ketter TA, Parekh PI, Herscovitch P, Post RM (1996) Gender differences in regional cerebral blood flow during transient self-induced sadness or happiness. Biol Psychiatry 40: 859–871PubMedCrossRefGoogle Scholar
  18. 18.
    George MS, Ketter TA, Parekh PI, Horwitz B, Herscovitch P, Post RM (1995) Brain activity during transient sadness and happiness in healthy women. Am J Psychiatry 152: 341–351PubMedGoogle Scholar
  19. 19.
    Good CD, Johnsrude I, Ashburner J, Henson RN, Friston KJ, Frackowiak RS (2001) Cerebral asymmetry and the effects of sex and handedness on brain structure: A voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 14: 685–700PubMedCrossRefGoogle Scholar
  20. 20.
    Gorno-Tempini ML, Pradelli S, Serafini M, Pagnoni G, Baraldi P, Porro C, Nicoletti R, Umita C, Nichelli P (2001) Explicit and incidental facial expression processing: An fMRI study. Neuroimage 14: 465–473PubMedCrossRefGoogle Scholar
  21. 21.
    Gur RC, Alsop DC, Glahn DC, Petty R, Swanson CL, Maldjian JA, Turetsky BI, Detre JA, Gee J, Gur RE (2000) An fMRI study of sex differences in regional activation to a verbal and a spatial task. Brain Lang 74: 157–170PubMedCrossRefGoogle Scholar
  22. 22.
    Gur RC, Mozley LH, Mozley PD, Resnick SM, Karp JS, Alavi A, Arnold SE, Gur RE (1995) Sex differences in regional cerebral glucose metabolism during a resting state. Science 267: 528–531PubMedCrossRefGoogle Scholar
  23. 23.
    Gur RC, Mozley PD, Resnick SM, Gottlieb GL, Kohn M, Zimmerman R, Herman G, Atlas S, Grossman R, Berretta D et al (1991) Gender differences in age effect on brain atrophy measured by magnetic resonance imaging. Proc Natl Acad Sci U S A 88: 2845–2849PubMedCrossRefGoogle Scholar
  24. 24.
    Gur RE, Turetsky BI, Cowell PE, Finkelman C, Maany V, Grossman RI, Arnold SE, Bilker WB, Gur RC (2000) Temporolimbic volume reductions in schizophrenia. Arch Gen Psychiatry 57: 769–775PubMedCrossRefGoogle Scholar
  25. 25.
    Habel U, Gur RC, Mandai MK, Salloum JB, Gur RE, Schneider F (2000) Emotional processing in schizophrenia across cultures: Standardized measures of discrimination and experience. Schizophr Res 42: 57–66PubMedCrossRefGoogle Scholar
  26. 26.
    Habel U, Schneider F (2001) Emotionale Dysfunktionen schizophrener Patienten: Ergebnisse der funktionellen Kernspintomographie. Psycho 26: 92–96Google Scholar
  27. 27.
    Hager F, Volz HP, Gaser C, Mentzel HJ, Kaiser WA, Sauer H (1998) Challenging the anterior attentional system with a continuous performance task: A functional magnetic resonance imaging approach. Eur Arch Psychiatry Clin Neurosci 248: 161–170PubMedCrossRefGoogle Scholar
  28. 28.
    Hariri AR, Bookheimer SY, Mazziotta JC (2000) Modulating emotional responses: effects of a neocortical network on the limbic system. Neuroreport 11: 43–48PubMedCrossRefGoogle Scholar
  29. 29.
    Haxby JV, Ungerleider LG, Horwitz B, Maisog JM, Rapoport SI, Grady CL (1996) Face encoding and recognition in the human brain. Proc Natl Acad Sci USA 93: 922–927PubMedCrossRefGoogle Scholar
  30. 30.
    Häfner H, Vander HW, Behrens S, Gattaz WF, Hambrecht M, Loffler W, Maurer K, Munk-Jorgensen P, Nowotny B, Riecher-Rossler A, Stein A (1998) Causes and consequences of the gender difference in age at onset of schizophrenia. Schizophr Bull 24: 99–113PubMedCrossRefGoogle Scholar
  31. 31.
    Hirayasu Y, Tanaka S, Shenton ME, Salisbury DF, DeSantis MA, Levitt J J, Wible C, Yurgelun-Todd D, Kikinis R, Jolesz FA, McCarley RW (2001) Prefrontal gray matter volume reduction in first episode schizophrenia. Cereb Cortex 11: 374–381PubMedCrossRefGoogle Scholar
  32. 32.
    Hulshoff Pol HE, Schnack HG, Mandl RC, van Haren NE, Koning H, Collins DL, Evans AC, Kahn RS (2001) Focal gray matter density changes in schizophrenia. Arch Gen Psychiatry 58: 1118–1125PubMedCrossRefGoogle Scholar
  33. 33.
    Iidaka T, Omori M, Murata T, Kosaka H, Yonekura Y, Okada T, Sadato N (2001) Neural interaction of the amygdala with the prefrontal and temporal cortices in the processing of facial expressions as revealed by fMRI. J Cogn Neurosci 13: 1035–1047PubMedCrossRefGoogle Scholar
  34. 34.
    Irwin W, Davidson RJ, Lowe MJ, Mock BJ, Sorenson JA, Turski PA (1996) Human amygdala activation detected with echo-planar functional magnetic resonance imaging. Neuroreport 7: 1765–1769PubMedCrossRefGoogle Scholar
  35. 35.
    Jäncke L, Specht K, Mirzazade S, Loose R, Himmelbach M, Lutz K, Shah NJ (1998) A parametric analysis of the ‘rate effect’ in the sensorimotor cortex: A functional magnetic reso-nance imaging analysis in human subjects. Neurosci Lett 252: 37–40PubMedCrossRefGoogle Scholar
  36. 36.
    Kaplan RD, Szechtman H, Franco S, Szechtman B, Nahmias C, Garnett ES, List S, Cleghorn JM (1993) Three clinical syndromes of schizophrenia in untreated subjects: Relation to brain glucose activity measured by positron emission tomography (PET). Schizophr Res 11: 47–54PubMedCrossRefGoogle Scholar
  37. 37.
    Keshavan MS, Montrose DM, Pierri JN, Dick EL, Rosenberg D, Talagala L, Sweeney JA (1997) Magnetic resonance imaging and spectroscopy in offspring at risk for schizophrenia: Preliminary studies. Prog Neuropsychopharmacol Biol Psychiatry 21: 1285–1295PubMedCrossRefGoogle Scholar
  38. 38.
    Kesler-West ML, Andersen AH, Smith CD, Avison MJ, Davis CE, Kryscio RJ, Blonder LX (2001) Neural substrates of facial emotion processing using fMRI. Brain Res Cogn Brain Res 11: 213–226PubMedCrossRefGoogle Scholar
  39. 39.
    Killgore WD, Yurgelun-Todd DA (2001) Sex differences in amygdala activation during the perception of facial affect. Neuroreport 12: 2543–2547PubMedCrossRefGoogle Scholar
  40. 40.
    Kulynych JJ, Vladar K, Jones DW, Weinberger DR (1994) Gender differences in the normal lateralization of the supratemporal cortex: MRI surface-rendering morphometry of Heschl’s gyrus and the planum temporale. Cereb Cortex 4: 107–118PubMedCrossRefGoogle Scholar
  41. 41.
    LaBar KS, Gatenby JC, Gore JC, LeDoux JE, Phelps EA (1998) Human amygdala activation during conditioned fear acquisition and extinction: A mixed-trial fMRI study. Neuron 20: 937–945PubMedCrossRefGoogle Scholar
  42. 42.
    Lane RD, Reiman RM, Ahern Gl, Schwartz GE, Davidson RJ (1997) Neuroanatomical cor-relatres of happiness, sadness and disgust. Am J Psychiatry 154: 926–933PubMedGoogle Scholar
  43. 43.
    Lauriello J, Bustillo J, Keith SJ (1999) A critical review of research on psychosocial treatment of schizophrenia. Biol Psychiatry 46: 1409–1417PubMedCrossRefGoogle Scholar
  44. 44.
    Lawrie SM, Whalley H, Kestelman JN, Abukmeil SS, Byrne M, Hodges A, Rimmington JE, Best JJK, Owens DGC, Johnstone EC (1999) Magnetic resonsance imaging of brain in people at high risk of developing schizophrenia. The Lancet 353: 30–33CrossRefGoogle Scholar
  45. 45.
    LeDoux JE (1994) Emotion, memory and the brain. Sci Am 270: 50–57PubMedCrossRefGoogle Scholar
  46. 46.
    Leung A, Chue P (2000) Sex differences in schizophrenia, a review of the literature. Acta Psychiatr Scand 401: 3–38CrossRefGoogle Scholar
  47. 47.
    Levin JM, Frederick BB, Ross MH, Fox JF, von Rosenberg HL, Kaufman MJ, Lange N, Mendelson JH, Cohen BM, Renshaw PF (2001) Influence of baseline hematocrit and hemo-dilution on BOLD fMRI activation. Magn Reson Imaging 19: 1055–1062PubMedCrossRefGoogle Scholar
  48. 48.
    Levin JM, Ross MH, Mendelson JH, Mello NK, Cohen BM, Renshaw PF (1998) Sex differences in blood-oxygenation-level-dependent functional MRI with primary visual stimulation. Am J Psychiatry 155: 434–436PubMedGoogle Scholar
  49. 49.
    Liberzon I, Taylor SF, Fig LM, Decker LR, Koeppe RA, Minoshima S (2000) Limbic activation and psychophysiologic responses to aversive visual stimuli. Interaction with cognitive task. Neuropsychopharmacol 23: 508–516CrossRefGoogle Scholar
  50. 50.
    Liddle PF (1987) Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychol Med 17: 49–57PubMedCrossRefGoogle Scholar
  51. 51.
    Liddle PF, Friston KJ, Frith CD, Hirsch SR, Jones T, Frackowiak RS (1992) Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry 160: 179–186PubMedCrossRefGoogle Scholar
  52. 52.
    Maccby E, Jacklin C (1974) The psychology of sex differences. Stanford: Stanford University PressGoogle Scholar
  53. 53.
    Matsumoto H, Simmons A, Williams S, Hadjulis M, Pipe R, Murray R, Frangou S (2001) Superior temporal gyrus abnormalities in early-onset schizophrenia: similarities and differences with adult-onset schizophrenia. Am J Psychiatry 158: 1299–1304PubMedCrossRefGoogle Scholar
  54. 54.
    Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, Silva JA, Tekell JL, Martin CC, Lancaster JL, Fox PT (1999) Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness. Am J Psychiatry 156: 675–682PubMedGoogle Scholar
  55. 55.
    Moriarty PJ, Lieber D, Bennett A, White L, Parrella M, Harvey PD, Davis KL (2001) Gender differences in poor outcome patients with lifelong schizophrenia. Schizophr Bull 27: 103–113PubMedCrossRefGoogle Scholar
  56. 56.
    Morris JS, Büchel C, Dolan RJ (2001) Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning. Neuroimage 13: 1044–1052PubMedCrossRefGoogle Scholar
  57. 57.
    Morris JS, Friston KJ, Büchel C, Frith CD, Young AW, Calder AJ, Dolan RJ (1998) A neuro-modulatory role for the human amygdala in processing emotional facial expressions. Brain 121: 47–57PubMedCrossRefGoogle Scholar
  58. 58.
    Mueser KT, Doonan R, Penn DL, Blanchard JJ, Bellack AS, Nishith P, DeLeon J (1996) Emotion recognition and social competence in chronic schizophrenia. J Abnorm Psychol 105: 271–275PubMedCrossRefGoogle Scholar
  59. 59.
    Narr KL, Thompson PM, Sharma T, Moussai J, Blanton R, Anvar B, Edris A, Krupp R, Rayman J, Khaledy M, Toga AW (2001) Three-dimensional mapping of temporo-limbic regions and the lateral ventricles in schizophrenia: Gender effects. Biol Psychiatry 50: 84–97PubMedCrossRefGoogle Scholar
  60. 60.
    Nopoulos P, Flaum M, O’Leary D, Andreasen NC (2000) Sexual dimorphism in the human brain: Evaluation of tissue volume, tissue composition and surface anatomy using magnetic resonance imaging. Psychiatry Res 98: 1–13PubMedCrossRefGoogle Scholar
  61. 61.
    Nordahl TE, Kusubov N, Carter C, Salamat S, Cummings AM, O’Shora-Celaya L, Eberling J, Robertson L, Huesman RH, Jagust W, Budinger TF (1996) Temporal lobe metabolic differences in medication-free outpatients with schizophrenia via the PET-600. Neuropsychopharmacology 15: 541–554PubMedCrossRefGoogle Scholar
  62. 62.
    Ojemann GA, Ojemann JG, Haglund M, Holmes M, Lettich E (1993) Visually related activity in human temporal cortical neurons. In: Gulyaas B, Ottoson D, Roland PE (Hrsg) Functional Organisation of the Human Cortex Oxford: Pergamon; 279–289Google Scholar
  63. 63.
    Pardo JV, Pardo PJ, Raichle ME (1993) Neural correlates of self-induced dysphoria. Am J Psychiatry 150: 713–719PubMedGoogle Scholar
  64. 64.
    Phillips ML, Bullmore ET, Howard R, Woodruff PW, Wright IC, Williams SC, Simmons A, Andrew C, Brammer M, David AS (1998) Investigation of facial recognition memory and happy and sad facial expression perception: An fMRI study. Psychiatry Res 83: 127–138PubMedCrossRefGoogle Scholar
  65. 65.
    Phillips ML, Williams L, Senior C, Bullmore ET, Brammer MJ, Andrew C, Williams SC, David AS (1999) A differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics. Psychiatry Res 92: 11–31PubMedCrossRefGoogle Scholar
  66. 66.
    Posse S, Fitzgerald D, Habel U, Rosenberg D, Moore GJ, Schneider F. Activation of amygdala during sad mood induction oberserved in single trials with real-time fMRI. Hum Brain Mapp (eingereicht)Google Scholar
  67. 67.
    Raz N, Gunning-Dixon F, Head D, Williamson A, Acker JD (2001) Age and sex differences in the cerebellum and the ventral pons: A prospective MR study of healthy adults. Am J Neu-roradiol22: 1161–1167Google Scholar
  68. 68.
    Raz N, Gunning FM, Head D, Dupuis JH, McQuain J, Briggs SD, Loken WJ, Thornton AE, Acker JD (1997) Selective aging of the human cerebral cortex observed in vivo: Differential vulnerability of the prefrontal gray matter. Cereb Cortex 7: 268–282PubMedCrossRefGoogle Scholar
  69. 69.
    Reiman EM, Lane RD, Ahern Gl, Schwartz GE, Davidson RJ, Friston KJ, Yun LS, Chen K (1997) Neuroanatomical correlates of externally and internally generated human emotion. Am J Psychiatry 154: 918–925PubMedGoogle Scholar
  70. 70.
    Reite M, Sheeder J, Teale P, Adams P, Richardson D, Simon J, Jones RH, Rojas DC (1997) Magnetic source imaging evidence of sex differences in cerebral lateralization in schizophrenia. Arch Gen Psychiatry 54: 433–440PubMedCrossRefGoogle Scholar
  71. 71.
    Reite M, Sheeder J, Teale P, Richardson D, Adams M, Simon J (1995) MEG based brain laterality: Sex differences in normal adults. Neuropsychologia 33: 1607–1616PubMedCrossRefGoogle Scholar
  72. 72.
    Reske M, Habel U, Falkai P, Shah NJ, Zilles K, Gaebel W, Schneider F (2001) Neurobiological correlates of olfactory processing in schizophrenic patients and their first degree relatives. World J Biol Psychiatry 2: 89CrossRefGoogle Scholar
  73. 73.
    Reynolds GP (1983) Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature 305: 527–529PubMedCrossRefGoogle Scholar
  74. 74.
    Reynolds GP, Czudek C, Andrews HB (1990) Deficit and hemispheric asymmetry of G AB A uptake sites in the hippocampus in schizophrenia. Biol Psychiatry 27: 1038–1044PubMedCrossRefGoogle Scholar
  75. 75.
    Riehemann S, Volz HP, Stutzer P, Smesny S, Gaser C, Sauer H (2001) Hypofrontality in neu-roleptic-naive schizophrenic patients during the Wisconsin Card Sorting Test-a fMRI study. Eur Arch Psychiatry Clin Neurosci 251: 66–71PubMedCrossRefGoogle Scholar
  76. 76.
    Schneider F, Ellgring H, Friedrich J, Fus I, Beyer T, Heimann H, Himer W (1992) The effects of neuroleptics on facial action in schizophrenic patients. Pharmacopsychiatry 25: 233–239PubMedCrossRefGoogle Scholar
  77. 77.
    Schneider F, Grodd W, Weiss U, Klose U, Mayer KR, Nagele T, Gur RC (1997) Functional MRI reveals left amygdala activation during emotion. Psychiatry Res 16: 75–82Google Scholar
  78. 78.
    Schneider F, Gur RC, Gur RE, Muenz LR (1994) Standardized mood induction with happy and sad facial expressions. Psychiatry Res 51: 19–31PubMedCrossRefGoogle Scholar
  79. 79.
    Schneider F, Gur RC, Gur RE, Shtasel DL (1995) Emotional processing in schizophrenia: neurobehavioral probes in relation to psychopathology. Schizophr Res 17: 67–75PubMedCrossRefGoogle Scholar
  80. 80.
    Schneider F, Gur RC, Gur RE, Shtasel DL (1995) Emotional processing in schizophrenia: Neurobehavioral probes in relation to psychopathology. Schizophr Res 17: 67–75PubMedCrossRefGoogle Scholar
  81. 81.
    Schneider F, Gur RC, Jaggi JL, Gur RE (1994) Differential effects of mood on cortical cerebral blood flow: A 133xenon clearance study. Psychiatry Res 52: 215–236PubMedCrossRefGoogle Scholar
  82. 82.
    Schneider F, Gur RE, Mozley LH, Smith RJ, Mozley PD, Censits DM, Alavi A, Gur RC (1995) Mood effects on limbic blood flow correlate with emotional self-rating: A PET study with oxygen-15 labeled water. Psychiatry Res 61: 265–283PubMedCrossRefGoogle Scholar
  83. 83.
    Schneider F, Habel U, Kessler C, Posse S, Grodd W, Müller-Gärtner HW (2000) Functional imaging of conditioned aversive emotional responses in antisocial personality disorder. Neuropsychobiol 42: 192–201CrossRefGoogle Scholar
  84. 84.
    Schneider F, Habel U, Kessler C, Salloum JB, Posse S (2000) Gender differences in regional cerebral activity during sadness. Hum Brain Mapp 9: 226–238PubMedCrossRefGoogle Scholar
  85. 85.
    Schneider F, Koch JD, Mattes R, Heimann H (1992) Das Erkennen von Emotionen aus dem Gesichtsausdruck bei visuellen Halbfelddarbietungen durch schizophrene und depressive Patienten. Nervenarzt 63: 545–550PubMedGoogle Scholar
  86. 86.
    Schneider F, Weiss U (1998) Neurobehavioral substrates of mood induction In: Ebert D, Ebmeier KP (Hrsg) New Models for Depression. Basel: Karger; S 34–48CrossRefGoogle Scholar
  87. 87.
    Schneider F, Weiss U, Kessler C, Salloum JB, Posse S, Grodd W, Müller-Gärtner H-W (1998) Differential amygdala activation in schizophrenia during sadness. Schizophr Res 34: 133–142PubMedCrossRefGoogle Scholar
  88. 88.
    Schneider F, Weiss U, Salloum JB, Posse S (1999) Real time analysis of amygdala activation. Neuroimage 9:912Google Scholar
  89. 89.
    Schröder J, Bubeck B, Silvestri S, Demisch S, Sauer H (1997) Gender differences in D2 dopamine receptor binding in drug-naive patients with schizophrenia: An [123I]iodoben-zamide single photon emission computed tomography study. Psychiatry Res 75: 115–123PubMedCrossRefGoogle Scholar
  90. 90.
    Sedvall G (1992) The current status of PET scanning with respect to schizophrenia. Neuropsychopharmacol 7: 41–54Google Scholar
  91. 91.
    Seidman LJ, Faraone SV, Goldstein JM, Goodman JM, Kremen WS, Toomey R, Tourville J, Kennedy D, Makris N, Caviness VS, Tsuang MT (1999) Thalamic and amygdala-hippocam-pal volume reductions in first-degree relatives of patients with schizophrenia: An MRI-based morphometric analysis. Biol Psychiatry 46: 941–954PubMedCrossRefGoogle Scholar
  92. 92.
    Szeszko PR, Bilder RM, Lencz T, Ashtari M, Goldman RS, Reiter G, Wu H, Lieberman JA (2000) Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophrenia. Schizophr Res 43: 97–108PubMedCrossRefGoogle Scholar
  93. 93.
    Tamminga CA, Thaker GK, Buchanan R, Kirkpatrick B, Alphs LD, Chase TN, Carpenter WT (1992) Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch Gen Psychiatry 49: 522–530PubMedCrossRefGoogle Scholar
  94. 94.
    Teasdale JD, Howard RJ, Cox SG, Ha Y, Brammer MJ, Williams SC, Checkley SA (1999) Functional MRI study of the cognitive generation of affect. Am J Psychiatry 156: 209–215PubMedGoogle Scholar
  95. 95.
    Turetsky B, Cowell PE, Gur RC, Grossman RI, Shtasel DL, Gur RE (1995) Frontal and temporal lobe brain volumes in schizophrenia. Relationship to symptoms and clinical subtype. Arch Gen Psychiatry 52: 1061–1070PubMedCrossRefGoogle Scholar
  96. 96.
    Usall J, Araya S, Ochoa S, Busquets E, Gost A, Marquez M (2001) Gender differences in a sample of schizophrenic outpatients. Compr Psychiatry 42: 301–305PubMedCrossRefGoogle Scholar
  97. 97.
    Volz H, Gaser C, Hager F, Rzanny R, Ponisch J, Mentzel H, Kaiser WA, Sauer H (1999) Decreased frontal activation in schizophrenics during stimulation with the continuous performance test-a functional magnetic resonance imaging study. Eur Psychiatry 14: 17–24PubMedCrossRefGoogle Scholar
  98. 98.
    Watson D, Clark LA, Tellegen A (1988) Development and validation of brief measures of positive and negative affect: The PANAS scales. J Pers Soc Psychol 54: 1063–1070PubMedCrossRefGoogle Scholar
  99. 99.
    Weinberger DR, Berman KF, Suddath R, Torrey EF (1992) Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: A magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. Am J Psychiatry 149: 890–897PubMedGoogle Scholar
  100. 100.
    Weiss U (1998) Funktionelle Kernspintomographie von Emotionen schizophrener Patienten. Dissertation an der Fakultät für Sozial-und Verhaltenswissenschaften der Eberhard-Karls-Universität Tübingen. Berichte des Forschungszentrums Jülich. Institut für MedizinGoogle Scholar
  101. 101.
    Weiss U, Salloum JB, Schneider F (1999) Correspondence of emotional self-rating with facial expression. Psychiatry Res 86: 175–184PubMedCrossRefGoogle Scholar
  102. 102.
    Whitworth AB, Honender M, Kremser C, Kemmler G, Felber S, Hausmann A, Wanko C, Wechdorn H, Aichner F, Stuppaeck CH, Fleischhacker WW (1998) Hippocampal volume reduction in male schizophrenic patients. Schizophr Res 31: 73–81PubMedCrossRefGoogle Scholar
  103. 103.
    Wilke M, Kaufmann C, Grabner A, Putz B, Wetter TC, Auer DP (2001) Gray matter-changes and correlates of disease severity in schizophrenia: a statistical parametric mapping study. Neuroimage 13: 814–824PubMedCrossRefGoogle Scholar
  104. 104.
    Witelson SF, Kigar DL (1992) Sylvian fissure morphology and asymmetry in men and women: Bilateral differences in relation to handedness in men. J Comp Neurol 323: 326–340PubMedCrossRefGoogle Scholar
  105. 105.
    Woods BT (1998) Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am J Psychiatry 155: 1661–1670PubMedGoogle Scholar
  106. 106.
    Wölwer W, Streit M, Polzer U, Gaebel W (1996) Facial affect recognition in the course of schizophrenia. Eur Arch Psychiatry Clin Neurosci 246: 165–170PubMedCrossRefGoogle Scholar
  107. 107.
    Zilles K, Schleicher A, Langemann C, Amunts K, Morosan P, Palomero-Gallagher N, Schormann T, Mohlberg H, Biirgel U, Steinmetz H, Schlaug G, Roland PE (1997) A quantitative analysis of sulci in the human cerebral cortex: Development, regional heterogeneity, gender difference, asymmetry, inter subject variability and cortical architecture. Hum Brain Mapp 5: 218–221PubMedCrossRefGoogle Scholar

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  • F. Schneider
  • U. Habel

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