Zusammenfassung
Patienten mit schweren linksventrikulären Funktionsstörungen haben trotz einer verbesserten Arzneimitteltherapie eine schlechte Prognose und sind häufing auf eine Herztransplantation angewiesen. Angesichts rückläufiger Organspenden und einem gleichzeitig steigenden Organbedarf besteht eine dringende Notwendigkeit, neue Behandlungsstrategien zu entwickeln. Künstliches, in vitro hergestelltes Herzgewebe (Tissue Engineering) könnte als Gewebeersatz eine neue Option zur Behandlung darstellen, wenn bestimmte Voraussetzungen erfüllt sind. Dies sind v. a. Methoden zur Herstellung von ausreichend dicken Gewebekonstrukten mit optimierter kontraktiler Funktion, ihre Integration ins Empfängermyokard sowie die Verfügbarkeit von geeignetem und ausreichendem Zellmaterial.
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Literatur
Agrawal CM, Athanasiou KA (1997) Technique to control pH in vicinity of biodegrading PLA-PGA implants. J Biomed Mater Res 38: 105–114
Akins RE et al. (1999) Cardiac organogenesis in vitro: reestablishment of three-dimensional tissue architecture by dissociated neonatal rat ventricular cells. Tissue Eng 5: 103–118
Bursac N et al. (1999) Cardiac muscle tissue engineering: toward an in vitro model for electrophysiological studies. Am J Physiol 277: H433–H444
Cebotari S et al. (2002) Construction of autologous human heart valves based on an acellular allograft matrix. Circulation 106: I63–I68
Eschenhagen T et al. (1997) Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system. Faseb J 11: 683–694
Fink C et al. (2000) Chronic stretch of engineered heart tissue induces hypertrophy and functional improvement. Faseb J 14: 669–679
Godbey WT, Atala A (2002) In vitro systems for tissue engineering. Ann N Y Acad Sci 961: 10–26
Hoerstrup SP et al. (2001) Tissue engineering of small caliber vascular grafts. Eur J Cardiothorac Surg 20: 164–169
Hoerstrup SP et al. (2002) Tissue engineering of functional trileaflet heart valves from human marrow stromal cells. Circulation 106: I143–1150
Kehat I et al. (2001) Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 108: 407–414
Langer R, Vacanti JP (1993) Tissue engineering. Science 260: 920–926
Leor J et al. (2000) Bioengineered cardiac grafts: A new approach to repair the infarcted myocardium? Circulation 102: 156–161
Li RK et al. (2000) Construction of a bioengineered cardiac graft. J Thorac Cardiovasc Surg 119: 368–375
Mann BK, West JL (2001) Tissue engineering in the cardiovascular system: progress toward a tissue engineered heart. Anat Rec 263: 367–371
Mikos AG et al. (1998) Host response to tissue engineered devices. Adv Drug Deliv Rev 33: 111–139
Shimizu T et al. (2002) Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces. Circ Res 90: e40
Shinoka T et al. (1996) Tissue-engineered heart valves. Autologous valve leaflet replacement study in a lamb model. Circulation 94: 164–168
Sodian R et al. (2002) Application of stereolithography for scaffold fabrication for tissue engineered heart valves. Asaio J 48: 12–16
Steinhoff G et al. (2000) Tissue engineering of pulmonary heart valves on allogenic acellular matrix conduits: in vivo restoration of valve tissue. Circulation 102: 50–55
Zimmermann WH et al. (2000) Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes. Biotechnol Bioeng 68: 106–114
Zimmermann WH et al. (2002) Tissue engineering of a differentiated cardiac muscle construct. Circ Res 90: 223–230
Zimmermann WH et al. (2002) Cardiac grafting of engineered heart tissue in syngenic rats. Circulation 106:151–157
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Zimmermann, WH., Weyand, M., Eschenhagen, T. (2003). Kardiales Tissue Engineering. In: Feindt, P., Vetter, H.O., Weyand, M. (eds) Synopsis der biologischen und mechanischen Kreislaufunterstützung. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57385-9_26
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DOI: https://doi.org/10.1007/978-3-642-57385-9_26
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