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Modelle zum Wirkmechanismus der transkraniellen Magnetstimulation

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Elektromagnetische Therapien in der Psychiatrie

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Zusammenfassung

Analog zu den Ausführungen zum Wirkmechanismus der Elektroschockstimulation und der Elektrokrampftherapie bedarf es auch für den Wirkmechanismus der TMS und rTMS weiterer Forschung. Der bisherige therapeutische Einsatz am Menschen gründet sich also überwiegend auf den fehlenden Nachweis schwerwiegender Nebenwirkungen oder das Fehlen wirksamer Behandlungsverfahren. Bisher wurden verschiedene physiologische und biochemische Aspekte der TMS an Patienten (George u. Belmaker 2000), an gesunden Probanden (Nahas et al. 2001) und im Tiermodell untersucht (Lisanby u. Belmaker 2000). Beim Menschen sind TMS-induzierte Veränderungen der kortikalen Durchblutung mit der PET (Strafella u. Paus 2001), der SPECT (Conca et al. 2000) und der fMRI (Nahas et al. 2001) beschrieben worden sowie EEG-Veränderungen (Paus et al. 2001b) und insbesondere Änderungen der motorisch evozierten Potenziale (MEP) im motorischen System (Maeda et al. 2000). Untersuchungen zu TMS-induzierten Veränderungen im Liquor wurden bisher nur zu Patienten mit Morbus Parkinson publiziert (Shimamoto et al. 2001).

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  1. Universitätsklinik für Psychiatrie und Psychotherapie, Osianderstraße 24, 72076, Tübingen, Germany

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    Gerhard W. Eschweiler , Barbara Wild  & Mathias Bartels ,  & 

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Eschweiler, G.W. (2003). Modelle zum Wirkmechanismus der transkraniellen Magnetstimulation. In: Eschweiler, G.W., Wild, B., Bartels, M. (eds) Elektromagnetische Therapien in der Psychiatrie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57370-5_23

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