Zusammenfassung
Grundprinzip der konventionellen Therapie ist es, Stoffe, die therapeutisch eingesetzt werden sollen, in einer Produktionsstätte herzustellen und dann von extern, mehr oder weniger weit vom Zielort entfernt, einzusetzen. Dies geschieht in der Hoffnung, dass das Therapeutikum bis zur entscheidenden Stelle vordringen und dort so lange verweilen wird, bis es den gewünschten Effekt zeigt. Zentrale Vision der Gentherapie und wichtiges Ziel der molekularen Medizin ist eine fortschreitende Verbesserung der Zielgebundenheit des therapeutischen Agens.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Altman DA, Titus L, Hair GA, Boden SD (1999) Molecular biology and spinal disorders. Spine 24(7):723–730
Arend WP, Dayer JM (1995) Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arthritis and Rheumatology 38:151–160
Boden SD, Titus L, Hair GH, Liu Y, Viggeswarapu M, Nanes MS, Baranowski C (1998) Lumbar soine fusion by local gene therapy with cDNA encoding a novel osteoinductive protein (LMP-1). Spine 23(23):2486–2492
Evans CH, Robbins PD (2000a) Gene therapy in orthopaedics. Orthopaedic Nursing 19:16–22
Evans CH, Ghivizzani SC, Herndon JH, Wasko MC, Reinecke J, Wehlin P, Robbins PD (2000 b) Clinical trials in the gene therapy of arthritis. Clinical Orthopaedics and Related Research 379S:S300–S307
Frisbie DD, Ghivizzani SC, Robbins PD, Evans CH, Mcllwraith CW (2002) Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Therapy 9:12–20
Nishida K, Gilbertson LG, Evans CH, Kang JD (2000) Potential applications of gene therapy to the treatment of spinal disorders. Spine 25(10):1308–1314
Nishida K, Kang JD, Gilbertson LG, Moon S-H, Suh J-K, Vogt MT, Robbins PD, Evans CH (1999) Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: An in vivo study of adenovirus-mediated transfer of the human transforming growth factor β1 encoding gene. Spine 24(23):2419–2425
Nishida K, Kang JD, Suh JK, Robbins PD, Evans CH, Gilbertson LG (1998) Adenovirus-mediated gene transfer to nucleus pulposus cells: Implications for the treatment of intervertebral disc degeneration. Spine 23:2437–2442
Pearce RH, Grimmer BJ, Adams ME (1987) Degeneration and chemical composition of the human lumbar intervertebral disc. J Orthop Res 5(5):198–205
Reinecke J, Koch H, Meijer H, Granrath M, Sager M, Wehling P (1998) Transfer of therapeutic genes to cells of the disc, spinal nerve root, and vertebral bone of the lumbar spine. Neuro-Orthopedics 24:79–90
Thompson JP, Oegema TR Jr, Bradford DS (1991) Stimulation of mature canine intervertebral disc by growth factors. Spine 16(3):253–260
Wehling P, Schulitz KP, Robbins PD, Evans CH, Reinecke J (1997) Transfer of genes to chondrocytic cells of the lumbar spine. Spine 22(10):1092–1097
Wooley PH, Whalen JD, Chapman DL, Berger AE, Richard KA, Aspar DG, Staite ND (1993) The effect of interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice. Arthritis and Rheumatology 36:1305–1312
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Becker, C., Ortiga, A.M.R., Wehling, P. (2003). Behandlung lumbaler Erkrankungen mittels Gentherapie. In: Breitenfelder, J., Haaker, R. (eds) Der lumbale Bandscheibenvorfall. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57361-3_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-57361-3_17
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-7985-1421-8
Online ISBN: 978-3-642-57361-3
eBook Packages: Springer Book Archive