Abstract
When naive T cells home to lymph nodes, they first roll along high endothelial venules using CD62L, allowing the chemokine receptor CCR7 to engage its ligand, SLC, displayed by endothelial cells. The CCR7-SLC interaction activates integrins that promote firm adhesion and transmigration of the T cells into the lymph node (Butcher and Picker, 1996; Cyster, 1999).
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Sallusto, F., Langenkamp, A., Geginat, J., Lanzavecchia, A. (2000). Functional Subsets of Memory T Cells Identified by CCR7 Expression. In: Melchers, F. (eds) Lymphoid Organogenesis. Current Topics in Microbiology and Immunology, vol 251. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57276-0_21
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DOI: https://doi.org/10.1007/978-3-642-57276-0_21
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