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Immunologische Aspekte von Schwangerschaft und Geburt

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Frühgeburt und Frühgeborenes

Zusammenfassung

Die menschliche Schwangerschaft wird von 2 grundlegenden Phänomenen gekennzeichnet. Sie ist ein natürliches Beispiel für eine erfolgreiche, wenn auch zeitlich begrenzte Transplantation und für einen invasiv wachsenden Tumor, der bis auf die klinisch relevanten Beispiele der Placenta percreta, der Blasenmole und des Chorionkarzinoms in seinem Wachstumspotential begrenzt bleibt. Der Erfolg dieses biologischen Projektes, das mit dem Einsetzen von Wehen und der Fruchtaustreibung endet, setzt eine phasenabhängige und vielschichtig abgestufte Interaktion und gegenseitige Regulation von mütterlichen und kindlichen Zellen voraus. Störungen wie Fehlanlagen, Fruchttot oder Infektionen führen fast immer zu uterinen Kontraktionen und zur Fruchtausstoßung.

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Literatur

  • Aarli A, Skeie-Jensen T, Ulvestad E, Matre R (1993) Suppression of mitogen-induced lymphoproliferation by soluble IgG Fc receptors in retroplacental serum in normal human pregnancy. Scand J Immunol 37: 237–243

    Article  PubMed  CAS  Google Scholar 

  • Adams DH, Wang L, Hubscher SG, Elias E, Neuberger JM (1989) Soluble interleukin-2 receptor in serum and bile of liver transplant recipients. Lancet 1(8636): 469–471

    Article  PubMed  CAS  Google Scholar 

  • Bazer FW, Hansen PJ (1991) Interferons secreted by sheep conceptuses are involved in maternal recognition of pregnancy. In: Wegmann TG, Gill TJ, Nisbet-Browon E (eds) Molecular and cellular immunobiology of the maternal fetal interface. Oxford University Press, Oxford, pp 232–242

    Google Scholar 

  • Biggar RJ, Pahwa S, Minkoff H, Mendes H, Willouhby A, Landesman S, Goedert JJ (1989) Immunosuppression in pregnant women infected with human immunodeficiency virus. Am J Obstet Gynecol 161: 1239–1244

    PubMed  CAS  Google Scholar 

  • Bizarro A, DeBellis A, Daponte A, Gallo R, Peimonte F, Russo N (1987) Decrease of TAC + lymphocytes in the periphal blood of pregnant patients with Grave’s disease. Rass Med Sper 34: 13–20

    Google Scholar 

  • Casey ML, Cox SM, Beutler B, Milewich L, MacDonald PC (1989) Cachectin/tumor necrosis factor-a formation in human decidua. J Clin Invest 83: 430–436

    Article  PubMed  CAS  Google Scholar 

  • Chaouat G, Menu E, Dijan V et al. (1993) Immune control of pregnancy. In: Chwalisz K, Garfield RE (eds) Ernst Schering Research Foundation Workshop 7-Basic mechanisms controlling term and preterm birth. Springer, Berlin Heidelberg New York Tokyo, pp 241–268

    Google Scholar 

  • Dudley DJ, Mitchell MD, Creighton K, Branch DW (1990) Lymphokine production during term human pregnancy: Differences between peripheral leukocytes and decidual cells. Am J Obstet Gynecol 163: 1890–1893

    PubMed  CAS  Google Scholar 

  • Farmer JL, Gottlieb AA, Nishihara T (1986) Inhibition of interleukin-2 production and expression of the interleukin-2 receptor by plasma from acquired immune deficiency syndrome patients. Clin Immunol Immunopathol 38: 235–243

    Article  PubMed  CAS  Google Scholar 

  • Hawes CS, Kemp AS, Jones WR, Need JA (1981) A longitudinal study of cell-mediated immunity in human pregnancy. J Reprod Immunol 3: 165–173

    Article  PubMed  CAS  Google Scholar 

  • Hill JA (1990) Immunological mechanisms of pregnancy maintenance and failure: A critique of theories and therapy. Am J Reprod Immunol 22: 33–42

    PubMed  CAS  Google Scholar 

  • Kanayama N, Fukamizu H (1989) Mechanical stretching increases prostaglandin E2 cultured human amnion cells. Gynecol Obstet Invest 28: 123–126

    Article  PubMed  CAS  Google Scholar 

  • Kauma S, Matt D, Strom S, Eierman D, Turner T (1990) Interleukin-1β human leukocyte antigen HLA-Dra, and transforming growth factor-β expression in endometrium, placenta and placental membranes. Am J Obstet Gynecol 163: 1430–1437

    PubMed  CAS  Google Scholar 

  • Lala PK (1989) Similarities between immunoregulation in pregnancy and malignancy: the role of prostaglandin E2. Am J Reprod Immunol 20: 147–152

    PubMed  CAS  Google Scholar 

  • Mardny EE, Kanayama N, Halin A, Machara K, Terao T (1996) Stretching of fetal membranes increases the concentration of interleukin-8 and collagenase activity. Am J Obstet Gynecol 174: 843–849

    Article  Google Scholar 

  • Mitchell MD, Ebenhack K, Kraemer DL et al. (1992) A sensitive radioimmunoassay for 11-deoxy-13, 14-dihydro-15-keto-11, 16-cyclo-prostaglandin E2: Application as an index of prostaglandin E2 biosynthesis during human pregnancy and parturition. Prostaglandins Leukot Med 9: 549–557

    Article  Google Scholar 

  • Newman GE, Phizackerley PJ, Lopez-Bernal A, Noble GR, Willis AC (1991) Absorption of fetal surfactant protein SP-B on the human amnion at term and on amniocytes incubated with fetal surfactant in vitro. Reprod Fertil Dev 4: 421–430

    Article  Google Scholar 

  • Pockley AG, Bolton AE (1989) Placental protein 14 (PP 14) inhibits the synthesis of interleukin-2 and the release of soluble interleukin-2 receptors from phytohaemagglutinin-stimulated lymphocytes. Clin Exp Immunol 77: 252–256

    PubMed  CAS  Google Scholar 

  • Rubin LA, Jay G, David LN (1986) The released interleukin-2 receptor binds interleukin-2 efficiently. J Immunol 137: 3841–3844

    PubMed  CAS  Google Scholar 

  • Saito S, Mashimoto H, Yonemasu K, Ichijo M (1990) Pregnancy zone protein inhibits production of interleukin-2 but does not affect interleukin-2 receptor expression of T cell activation. J Reprod Immunol 17: 115–126

    Article  PubMed  CAS  Google Scholar 

  • Sangha RK, Wolton JC, Ensor CM, Tai HH, Challis JR (1994) Immunohistochemical localisation, messenger ribonucleic acid abundance, and activity of 15-hydroxyprostaglandin dehydrogenase in placenta and fetal membranes during term and preterm labor. J Clin Endocrinol Metab 78: 982–989

    Article  PubMed  CAS  Google Scholar 

  • Satph T, Nakamura S, Taga T et al. (1988) Induction of neural differentiation in PC 12 cells by B cell stimulatory factor 2/interleukin 6. Mol Cell Biol 8: 3546

    Google Scholar 

  • Scandi C, Cambronero JC, Borrel J, Guaza C (1992) Mutually antagonistic effects of corticosterone and prolactin on rat lymphocyte proliferation. Neuroendocrinology 56: 574–581

    Article  Google Scholar 

  • Schäfer APA, Pauli G, Friedmann W, Dudenhausen JW (1992) Human choriogonadotropin (hCG) and placental lactogen (hPL) inhibit interleukin-2 (IL-2) and increase interleukin-1 (IL-1),-6 (IL-6), and tumor necrosis factor (TNF-a) expression in monocyte cell cultures. J Perinat Med 20: 252–257

    Article  Google Scholar 

  • Suzuki T, Hiromatsu K, Ando Y et al. (1995) Regulatory role of Xδ-T-cells in uterine intraepithelial lymphocytes in maternal antifetal immune response. J Immunol 154: 4476–4484

    PubMed  CAS  Google Scholar 

  • Uchiyama T, Ito A, Ikesue A, Nakagawa H, Mori Y (1992) Chemotactic factor in the pregnant rabbit uterine cervix. Am J Obstet Gynecol 167: 1417–1422

    PubMed  CAS  Google Scholar 

  • Wegmann TG (1988) Maternal T cells promote placental growth and prevent spontaneous abortion. Immunol Lett 17: 297

    Article  PubMed  CAS  Google Scholar 

  • Wilson T, Liggins GC, Whittacker DJ (1988) Oxytocin stimulates the release of arachidonic acid and prostaglandin F2a from human decidua cells. Prostaglandins 35: 771–780

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. A. Schäfer
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Editors and Affiliations

  1. Frauenklinik, Universität Rostock, Doberaner Straße 142, 18057, Rostock, Germany

    Klaus Friese  & Volker Briese  & 

  2. Kinder- und Jugendklinik, Universität Rostock, Rembrandtstraße 16/17, 18057, Rostock, Germany

    Christian Plath

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© 2000 Springer-Verlag Berlin Heidelberg

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Schäfer, A. (2000). Immunologische Aspekte von Schwangerschaft und Geburt. In: Friese, K., Plath, C., Briese, V. (eds) Frühgeburt und Frühgeborenes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57222-7_4

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  • DOI: https://doi.org/10.1007/978-3-642-57222-7_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63046-0

  • Online ISBN: 978-3-642-57222-7

  • eBook Packages: Springer Book Archive

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