Zusammenfassung
Ziele der Diabetestherapie sind Symptomfreiheit, Vermeidung von Spätkomplikationen und Verminderung der Letalität. Dieses wird in der Regel durch eine möglichst optimale Blutzuckereinstellung erreicht. Die kürzlich veröffentlichten Ergebnisse der UKPDS-Studie haben gezeigt, daß eine intensivierte Diabetestherapie mit einem HbA1c-Wert unter 7% über die ersten 10 Jahre nach der Diagnose die mikrovaskulären Komplikationen senkt (UK Prospective Diabetes Study Group 1998a).
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Literatur
Bailey C.J., Path M.R.C., Turner R.C. (1996): Metformin. New Engl. J. Med. 334: 574–579.
Berger M., Köbberling J., Windeier J. (1996): Wirksamkeit und Wertigkeit der Acarbose. Dtsch. Ärztebl. 93: B-443–444.
Chiasson J.L., Josse R.G., Hunt J.A., Palmason C., Rodger N.W. et al. (1994): The efficacy of acarbose in the treatment of patients with non-insulin-dependent diabetes mellitus. Ann. Intern. Med. 121: 928–935.
De Fronzo R.A., Goodman M. (1995): Efficacy of metformin in patients with noninsulin-dependent diabetes mellitus. New Engl. J. Med. 333: 541–549.
Dills D.G., Schneider J. (1996): Clinical evaluation of glimepiride versus glyburide in NIDDM in a double-blind comparative study. Glimepiride/Glyburide Research Group. Horm. Metab. Res. 28: 426–429.
Draeger K.E., Wernicke-Panten K., Lomp H.-J., Schüler E., Roßkamp R. (1996): Long-term treatment of type 2 diabetic patients with the new oral antidiabetic agent glimepiride (Amaryl®): a double-blind comparison with glibendamide. Horm. Metab. Res. 28: 419–425.
Dunn C.J., Peters D.H. (1995): Metformin-A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus. Drugs 49: 721–749.
Everett J., Kerr D. (1994): Changing from porcine to human insulin. Drugs 47: 286–296.
Holman R.R., Mayon White V., Orde-Peckar C., Steemson J., Smith B. et al. (1983): Prevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients: a two-year randomised prospective study. Lancet: 204–208.
Karam J.H., Etzwiler D.D. (eds.) (1983): International symposium on human insulin. Diabetes Care 6: 1–68.
Koivisto V.A. (1998): The human insulin analogue insulin lispro. Ann. Med. 30: 260–266.
Langtry H.D., Balfour J.A. (1998): Glimepiride. A review of its use in the management of Type 2 diabetes mellitus. Drugs 55: 563–584.
Nathan D.M. (1998): Some answers, more controversy, from UKPDS. (Commentary). Lancet 352: 832–833.
Rosenstock J., Samols E., Muchmore D.B., Schneider J. (1996): Glimepiride, a new once-daily sulfonylurea. A double-blind placebo-controlled study of NIDDM patients. Glimepiride Study Group. Diabetes Care 19: 1194–1199.
Sachse G. (1994): Acarbose-Behandlung als neues Therapieprinzip. Dtsch. Ärztebl. 91, Suppl. 15–17.
Stumvoll M., Nurjhan N., Perriello G., Dailey G., Gerich J.E. (1995): Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. New Engl. J. Med. 333: 550–554.
UK Prospective Diabetes Study (UKPDS) Group (1998a): Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352: 837–853.
UK Prospective Diabetes Study (UKPDS) Group (1998b): Effect of intensive bloodglucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352: 854–865.
Veneman T.P., Tack C.J., van Haeften T.W. (1998): The newly developed sulfonylurea glimepiride: a new ingredient, an old recipe. Neth. J. Med. 52: 179–186.
Wilde M.I., McTavish D. (1997): Insulin Lispro. A review of its pharmacological properties and therapeutic use in the management of diabetes mellitus. Drugs 54: 597–614.
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Mengel, K. (2000). Antidiabetika. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 1999. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57215-9_9
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