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Myocardial Ischemic Preconditioning

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Coronary Circulation and Myocardial Ischemia

Part of the book series: Update in Intensive Care Medicine ((UICMSOFT,volume 32))

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Abstract

Protection of ischemic myocardium through transient antecedent sublethal ischemia (myocardial ischemic preconditioning, IP) is a well established laboratory phenomenon which has caught the attention and imagination of clinicians and researchers throughout the world. The magnitude of protection against ischemic injury conferred by IP is tremendous, far surpassing that offered by past pharmacological therapies. Indirect evidence suggests that IP occurs in human hearts as well. But whether IP is a naturally occurring phenomenon in humans, or is relevant to the practice of clinical medicine, remains unclear.

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Authors and Affiliations

  1. Department of Anesthesiology, Veterans Affairs Medical Center and Oregon Health Sciences University, Portland, Oregon, USA

    D. M. Van Winkle

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Editors and Affiliations

  1. University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Michael R. Pinsky MD, CM, FCCP, FCCM (Director of Research Division of Critical Care Medicine Professor of Anesthesiology and Critical Care Medicine) (Director of Research Division of Critical Care Medicine Professor of Anesthesiology and Critical Care Medicine)

  2. Department of Cell Biology and Physiology, Autonomous University, Barcelona, Spain

    Antonio Artigas MD, PhD (Director of Critical Care Center Sabadell Hospital Associate Professor) (Director of Critical Care Center Sabadell Hospital Associate Professor)

  3. Paris, France

    Jean-Francois Dhainaut MD, PhD (Director of Medical Intensive Care Unit Dean of Cochin Port-Royal Medical School Vice-President of Paris University) (Director of Medical Intensive Care Unit Dean of Cochin Port-Royal Medical School Vice-President of Paris University)

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Van Winkle, D.M. (2002). Myocardial Ischemic Preconditioning. In: Pinsky, M.R., Artigas, A., Dhainaut, JF. (eds) Coronary Circulation and Myocardial Ischemia. Update in Intensive Care Medicine, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57212-8_3

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  • DOI: https://doi.org/10.1007/978-3-642-57212-8_3

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