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Immune Response in the Critically Ill pp 97–115Cite as

Bacterial Toxins Induce Selective Cytokine Patterns In Vivo and In Vitro

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Part of the book series: Update in Intensive Care Medicine ((UICMSOFT,volume 31))

Abstract

Sepsis due to Gram-negative, Gram-positive or fungal organisms is among the most common causes of death in intensive care units (ICUs) in Western society [1]. Currently, 28-day mortality in sepsis is estimated to be 20–40% depending on the etiological agent and presence of complicating medical disorders [2–6]. An even higher mortality has been associated with septic shock, affecting approximately half of the patients with sepsis. Investigations performed in patients included in recent immunomodulatory trials have estimated that 35–60% of patients with septic shock died within 28 days following onset of disease [7, 8].

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Author information

Authors and Affiliations

  1. Division of Infectious Diseases, Huddinge University Hospital, Huddinge, Sweden

    J. Andersson

  2. Department of Pediatrics, Huddinge University Hospital, Huddinge, Sweden

    U. Andersson

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  1. J. Andersson
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Editor information

Editors and Affiliations

  1. Department of Surgery Interdepartmental Division of Critical Care Medicine, Toronto General Hospital University of Toronto, Toronto, Ontario, Canada

    John C. Marshall MD (Professor of Surgery) (Professor of Surgery)

  2. Department of Infectious Diseases & Microbiology Division of Investigative Science, Imperial College School of Medicine Hammersmith Hospital, London, UK

    Jonathan Cohen FRCP, FRCPath, FRCPE, FMedSci (Chairman) (Chairman)

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© 2002 Springer-Verlag Berlin Heidelberg

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Andersson, J., Andersson, U. (2002). Bacterial Toxins Induce Selective Cytokine Patterns In Vivo and In Vitro . In: Marshall, J.C., Cohen, J. (eds) Immune Response in the Critically Ill. Update in Intensive Care Medicine, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57210-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-57210-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42589-2

  • Online ISBN: 978-3-642-57210-4

  • eBook Packages: Springer Book Archive

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