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Neutrophils and Acute Lung Injury

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Immune Response in the Critically Ill

Part of the book series: Update in Intensive Care Medicine ((UICMSOFT,volume 31))

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Abstract

The first detailed clinical-pathological description of “acute respiratory distress in adults’ [1] was provided by Asbaugh and colleagues, who, in 1967, identified a group of patients that could be differentiated from the majority of patients requiring intensive care management for severe respiratory failure on the following features:

  • Tachypnea and cyanosis refractory to oxygen treatment

  • Markedly reduced lung compliance upon mechanical ventilation

  • Diffuse alveolar shadowing on the chest radiograph

  • Pulmonary edema, congestion and hyaline membranes on histological examination of necropsy specimens

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Author information

Authors and Affiliations

  1. Department of Respiratory Medicine, University of Edinburgh Medical School, Edinburgh, UK

    C. Haslett

  2. Department of Medicine & Therapeutics, University College Dublin, St. Vincent’s Hospital, Dublin, Ireland

    S. Donnelly

  3. Rayne Laboratories, University of Edinburgh Medical School, Edinburgh, UK

    N. Hirani

Authors
  1. C. Haslett
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  2. S. Donnelly
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  3. N. Hirani
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Editor information

Editors and Affiliations

  1. Department of Surgery Interdepartmental Division of Critical Care Medicine, Toronto General Hospital University of Toronto, Toronto, Ontario, Canada

    John C. Marshall MD (Professor of Surgery) (Professor of Surgery)

  2. Department of Infectious Diseases & Microbiology Division of Investigative Science, Imperial College School of Medicine Hammersmith Hospital, London, UK

    Jonathan Cohen FRCP, FRCPath, FRCPE, FMedSci (Chairman) (Chairman)

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© 2002 Springer-Verlag Berlin Heidelberg

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Haslett, C., Donnelly, S., Hirani, N. (2002). Neutrophils and Acute Lung Injury. In: Marshall, J.C., Cohen, J. (eds) Immune Response in the Critically Ill. Update in Intensive Care Medicine, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57210-4_15

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  • DOI: https://doi.org/10.1007/978-3-642-57210-4_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42589-2

  • Online ISBN: 978-3-642-57210-4

  • eBook Packages: Springer Book Archive

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