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Das Immunsystem im Gastrointestinaltrakt — Mechanismen der Entzündung

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Klinische Gastroenterologie und Stoffwechsel

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Zusammenfassung

Der Gastrointestinaltrakt stellt mit 100–400 m2 die weitaus größte Oberfläche dar, mit der der Körper mit der Außenwelt in Kontakt steht. Im Darmlumen befinden sich zahlreiche Mikroorganismen und Substanzen, die für den Körper Fremdstoffe (Antigene) darstellen. Die Aufnahme dieser Antigene kann für den Menschen deletäre Folgen haben. Die Mukosa im Gastrointestinaltrakt muß deshalb über sehr effektive Mechanismen verfügen, um den Organismus vor dem Eindringen dieser Fremdstoffe zu schützen.

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Literatur

  • Allan CH, Mendrich DL, Trier JS (1993) Rat intestinal M cells contain acidic endosomal-lysosomal compartments and express class II major histocompatibility complex determinants. Gastroenterology 104: 698–708

    PubMed  CAS  Google Scholar 

  • Bland PW, Warren LG (1986) Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells. Immunology 58: 9–14

    PubMed  CAS  Google Scholar 

  • Blumberg RS, Terhorst C, Bleicher P et al. (1991) Expression of a nonpolymorphic MHC class I-like molekule, CD1d, by human intestinal epithelial cells. J Immunol 147: 2518–2524

    PubMed  CAS  Google Scholar 

  • Boughton-Smith NK (1995) Nitrix oxide in ulcerative colitis and Crohn’s disease. In: Tytgat GNJ, Bartelsman JFWM, van Deventer SJH (eds) Inflammatory bowel disease. Kluwer Academic Publishers, Dordrecht Boston London, pp 90–100

    Google Scholar 

  • Boussiotis VA, Freeman GJ, Gribben JG, Nadler LM (1996) The role of B7-l/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down regulation of the immune response. Immunol Rev 153: 5–26

    Article  PubMed  CAS  Google Scholar 

  • Carlos TM, Harlan JM (1994) Leukocyte-endothelial adhesion molecules. Blood 84: 2068–2101

    PubMed  CAS  Google Scholar 

  • Casini RV, Kam L, Chong YJ, Fiocchi C, Pizarro TT, Cominelli F (1995) Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation. J Immunol 154: 2434–2440

    Google Scholar 

  • Conley ME, Delacroix DL (1987) Intravascular and mucosal immunoglobulin A: two separate but related systems of immune defense? Ann Intern Med 106: 892–899

    PubMed  CAS  Google Scholar 

  • Duchmann R, Kaiser I, Hermann E, Mayet W, Ewe K, Meyer zum Büschenfelde K-H (1995) Tolerance exists towards intestinal flora but is broken in active inflammatory bowel diesease (IBD). Clin Exp Immunol 102: 448–455

    Article  PubMed  CAS  Google Scholar 

  • Fuss IJ, Neurath M, Boirivant M (1996) Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn’s disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157: 1261–1270

    PubMed  CAS  Google Scholar 

  • Gemsa D, Resch K (1997) Entzündung. In: Gemsa D, Kalden JR, Resch K (Hrsg) Immunologie, 4. Aufl. Thieme, Stuttgart New York, S 135–158

    Google Scholar 

  • Gross V, Arndt H, Andus T, Palitzsch KD, Schölmerich J (1994) Free radicals in inflammatory bowel diseases patho-physiology and therapeutic implications. Hepatogastroenterology 41: 320–327

    PubMed  CAS  Google Scholar 

  • Hermiston ML, Gordon JI (1995) Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270: 1203–1207

    Article  PubMed  CAS  Google Scholar 

  • Janeway CA, Travers P (1995) Immunologie. Spektrum Akademischer Verlag, Heidelberg Berlin Oxford

    Google Scholar 

  • Kaetzel CS, Robinson JK, Chintalacharuvu KR, Vaerman JP, Lamm ME (1991) The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA. Proc Natl Acad Sci USA 88: 8796–8800

    Article  PubMed  CAS  Google Scholar 

  • Kerneis S, Bogdanova A, Colucci GE, Kraehenbuhl JP, Pringault E (1996) Cytosolic distribution of villin in M cells from mouse Peyer’s patches correlates with the absence of a brush border. Gastroenterology 110: 515–521

    Article  PubMed  CAS  Google Scholar 

  • Kerneis S, Bogdanova A, Kraehenbuhl J-P, Pringault E (1997) Conversion by Peyer’s Patch Lymphocytes of Human Enterocytes into M cells that transport bacteria. Science 277: 949–952

    Article  PubMed  CAS  Google Scholar 

  • Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263–274

    Article  PubMed  CAS  Google Scholar 

  • Mahida YR, Wu KC, Jewell DP (1989) Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease. Gut 30: 1362–1370

    Article  PubMed  CAS  Google Scholar 

  • Marth T, Strober W, Kelsall BL (1996) High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis. J Immunol 157: 2348–2357

    PubMed  CAS  Google Scholar 

  • Mayer L, Eisenhardt D (1990) Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease. J Clin Invest 86: 1255–1260

    Article  PubMed  CAS  Google Scholar 

  • Mayer L, Shlien R (1987) Evidence for function of Ia molecules on gut epithelial cells in man. J Exp Med 166: 1471–1483

    Article  PubMed  CAS  Google Scholar 

  • Mochizuki K, Hayashi N, Katayama K et al. (1997) B7/BB-1 expression and hepatitis activity in liver tissues of patients with chronic hepatitis C. Hepatology 25: 713–718

    Article  PubMed  CAS  Google Scholar 

  • Mosmann TR, Coffman RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7: 145–173

    Article  PubMed  CAS  Google Scholar 

  • Owen RL, Pierce NF, Apple RT, Croy WCJ (1986) M cell transport of Vibrio cholerae from the intestinal lumen into Peyer’s patches: a mechanism for antigen sampling and for microbial transepithelial migration. J Infect Dis 153: 1108–1118

    Article  PubMed  CAS  Google Scholar 

  • Pirzer U, Schonhaar A, Fleischer B, Hermann E, Meyer zum Buschenfelde, K.-H. (1991) Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn’s disease. Lancet 338: 1238–1239

    Article  PubMed  CAS  Google Scholar 

  • Qiao L, Schurmann G, Betzler M, Meuer SC (1991) Activation and signaling status of human lamina propria T lymphocytes. Gastroenterology 101: 1529–1536

    PubMed  CAS  Google Scholar 

  • Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253–261

    Article  PubMed  CAS  Google Scholar 

  • Schreiber S, Heinig T, Panzer U, Reinking R, Bouchard A, Stahl PD, Raedler A (1995) Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease. Gastroenterology 108: 21–33

    Article  PubMed  CAS  Google Scholar 

  • Strobel S, Mowat AM, Ferguson A (1985) Prevention of oral tolerance induction to ovalbumin and enhanced antigen presentation during a graft-versus-host reaction in mice. Immunology 56: 57–64

    PubMed  CAS  Google Scholar 

  • Strober W, Kelsall B, Fuss I, Marth T, Ludviksson B, Ehrhardt R, Neurath M (1997) Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunol Today 18: 61–64

    Article  PubMed  CAS  Google Scholar 

  • Weiner HL, Friedman A, Miller A et al. (1994) Oral tolerance: Immunologic mechanisms and treatment of autoantigens. Annu Rev Immunol 12: 809–837

    Article  PubMed  CAS  Google Scholar 

  • Wyatt J, Vogelsang H, Hubl W, Waldhoer T, Lochs H (1993) Intestinal permeability and the prediction of relapse in Crohn’s disease. Lancet 341: 1437–1439

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. A. Stallmach
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  2. M. Zeitz
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Editor information

Editors and Affiliations

  1. Abt. Innere Medizin I, Universitätsklinik Ulm, 89070, Ulm, Germany

    G. Adler

  2. Departement Innere Medizin Abt. Gastroenterologie Kantonsspital Basel, Universitätskliniken, Petersgraben 4, 4031, Basel, Schweiz

    C. Beglinger

  3. Abt. Gastroenterologie und Hepatologie Zentrum Innere Medizin und Dermatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Germany

    M. P. Manns

  4. Abt. für Innere Medizin, Park-Klinik Weißensee, Schönstraße 80, 13086, Berlin, Germany

    S. Müller-Lissner

  5. Medizinische Universitätsklinik Knappschaftskrankenhaus, In der Schornau 23-25, 44892, Bochum, Germany

    W. Schmiegel

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© 2000 Springer-Verlag Berlin Heidelberg

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Stallmach, A., Zeitz, M. (2000). Das Immunsystem im Gastrointestinaltrakt — Mechanismen der Entzündung. In: Adler, G., Beglinger, C., Manns, M.P., Müller-Lissner, S., Schmiegel, W. (eds) Klinische Gastroenterologie und Stoffwechsel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57194-7_23

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  • DOI: https://doi.org/10.1007/978-3-642-57194-7_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65059-1

  • Online ISBN: 978-3-642-57194-7

  • eBook Packages: Springer Book Archive

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