Zusammenfassung
Die Krankheitsbilder der Pemphigusgruppe, Pemphigus vulgaris (PV), Pemphigus foliaceus (PF) und paraneoplastischer Pemphigus (PNP), sind durch Autoantikörper charakterisiert, die gegen Oberflächenantigene der Epidermalzellen gerichtet sind. Nach Identifizierung krankheitsspezifischer Zielstrukturen der Pemphigus-Antikörper gelang es kürzlich, ELISAs zur Diagnostik von PV (Desmoglein 3, Dsg3) und PF (Dsgi) zu entwickeln.
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Literatur
Amagai M, Karpati S, Prussick R, Klaus-Kovtun V, Stanley JR (1992) Autoantibodies against the amino-terminal cadherinlike binding domain of pemphigus vulgaris antigen are pathogenic. J Clin Invest 90:919–926
Amagai M, Hashimoto T, Shimizu N, Nishikawa T (1994) Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. J Clin Invest 94:59–67
Amagai M, Klaus-Kovtun V, Stanley JR (1997) Autoantibodies against a novel epithelial Cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 67:869–877
Amagai M, Nishikawa T, Nousari HC, Anhalt GJ, Hashimoto T (1998) Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in neonatal mice. J Clin Invest 102:775–782
Anhalt GJ, Emery DJ, Diaz LA, Fairley JA, Lopez A, Taylor AF, Giudice GJ (1995) Pemphigus foliaceus and pemphigus vulgaris autoantibodies react with the extracellular domain of desmoglein-1. J Invest Dermatol 104:323–328
Ishii K, Amagai M, Hall RP, Hashimoto T, Takayanagi A, Gamou S, Shimizu N, Nishikawa T (1997) Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. J Immunol 159:2010–2017
Lenz P, Amagai M, Volc-Platzer B, Stingl G, Kirnbauer R (1999) Desmoglein 3-ELISA: A Pemphigus vulgaris-specific diagnostic tool. Arch Dermatol 135:143–148
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Lenz, P., Volc-Platzer, B., Stingl, G., Kirnbauer, R. (2000). Desmoglein-ELISAs für die Routinediagnostik und Verlaufskontrolle von Pemphigus-Patienten. In: Plettenberg, A., Meigel, W.N., Moll, I. (eds) Dermatologie an der Schwelle zum neuen Jahrtausend. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57191-6_22
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DOI: https://doi.org/10.1007/978-3-642-57191-6_22
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