Skip to main content

Die Haut als Abwehrorgan: physikalisch-mechanische Permeabilitätsbarriere

  • Conference paper
Dermatologie an der Schwelle zum neuen Jahrtausend

Zusammenfassung

Zusammenfassend zeigen die Untersuchungen, daß bei Verletzung der mechanisch-physikalischen Barriere durch Noxen aus der Umwelt eine Reihe von biochemischen Vorgängen zur Abwehr induziert werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Ekanayake-Mudiyanselage S, Aschauer H, Schmook FP, Jensen JM, Meingassner J, Proksch E (1998) Expression of epidermal keratins and the cornified envelope protein involucrin is influenced by permeability barrier disruption. J Invest Dermatol 111:517–523

    Article  PubMed  CAS  Google Scholar 

  • Elias PM (1996) The stratum corneum revisited. J Dermatol 23: 756–758

    PubMed  CAS  Google Scholar 

  • Elias PM (1996) Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers. Exp Dermatol 5: 191–201

    Article  PubMed  CAS  Google Scholar 

  • Feingold KR (1991) The regulation and role of epidermal lipid synthesis. Adv Lipid Res 24: 57–82

    PubMed  CAS  Google Scholar 

  • Hofmeister R, Wiegmann K, Korherr C, Bernardo K, Krönke M, Falk W (1997) Activation of acid sphingomyelinase by inter-leukin-1 (I1-1) requires the I1-1 receptor accessory protein. J Biol Chem 31: 27730–27736

    Article  Google Scholar 

  • Jensen JM, Kupper TS, Proksch E (1998) Il-l(overexpression and knockout constructs in permeability barrier repair of transgenic mice. J Invest Dermatol 110: 499A

    Google Scholar 

  • Proksch E, Feingold KR, Elias PM (1991) Barrier function regulates epidermal DNA synthesis. J Clin Invest 87:1668–1673

    Article  PubMed  CAS  Google Scholar 

  • Proksch E, Holleran WM, Menon GK, Elias PM, Feingold KR (1993) Barrier function regulates epidermal lipid and DNA synthesis. Br J Dermatol 128:473–482

    Article  PubMed  CAS  Google Scholar 

  • Proksch E, Jensen JM, Krönke M, Schütze S (1998) TNF receptor p55 signaling and ceramides generated by sphingomyelinases in cutaneous barrier repair. J Invest Dermatol 110: 506A

    Google Scholar 

  • Schürer NY, Elias PM (1991) The biochemistry and function of stratum corneum lipids. Adv Lipid Res 24: 27–56

    PubMed  Google Scholar 

  • Wiegmann K, Schütze S, Machleidt T, Witte D, Krönke M (1994) Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78:1005–1015

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Proksch, E. (2000). Die Haut als Abwehrorgan: physikalisch-mechanische Permeabilitätsbarriere. In: Plettenberg, A., Meigel, W.N., Moll, I. (eds) Dermatologie an der Schwelle zum neuen Jahrtausend. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57191-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57191-6_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63042-2

  • Online ISBN: 978-3-642-57191-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics