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Drug-Nutrient Interactions in the Critically III

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From Nutrition Support to Pharmacologic Nutrition in the ICU

Part of the book series: Update in Intensive Care Medicine ((UICMSOFT,volume 34))

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Abstract

Drug-nutrient interactions in the critically ill patient have the potential to lead to decreased drug efficacy and/or increased drug toxicity. With the increased use of specialized nutritional support in patients requiring multiple medications, there is genuine concern about the possibility for pharmacologic-nutritional interactions, and the consequences of therapeutic outcomes [1, 2]. The frequency of drug interactions can be high in the critically ill patient because of the large number of drugs that they receive [3]. According to Sierra, et al. [3] most of these interactions are designated as being of moderate clinical importance with digoxin being the most frequently implicated drug.

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Author information

Authors and Affiliations

  1. University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

    J. A. Thomas

  2. Worldwide Regulatory Affairs, Monsanto Company, Skokie, Illinois, USA

    W. W. Stargel

  3. Nutritional Sciences Worldwide, Whitehall-Robins, Madison, New Jersey, USA

    R. Cotter

Authors
  1. J. A. Thomas
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  2. W. W. Stargel
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  3. R. Cotter
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Editor information

Editors and Affiliations

  1. University Hospital, 1211, Geneva 14, Switzerland

    Claude Pichard MD, PhD (Head of Clinical Nutrition) (Head of Clinical Nutrition)

  2. Department of Surgery, University of Wisconsin-Madison, Madison, WI 53706, USA

    Kenneth A. Kudsk MD (Professor of Surgery) (Professor of Surgery)

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© 2002 Springer-Verlag Berlin Heidelberg

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Thomas, J.A., Stargel, W.W., Cotter, R. (2002). Drug-Nutrient Interactions in the Critically III. In: Pichard, C., Kudsk, K.A. (eds) From Nutrition Support to Pharmacologic Nutrition in the ICU. Update in Intensive Care Medicine, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57119-0_13

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  • DOI: https://doi.org/10.1007/978-3-642-57119-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42604-2

  • Online ISBN: 978-3-642-57119-0

  • eBook Packages: Springer Book Archive

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