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Proteases as Targets for Therapy pp 95–115Cite as

The Human Herpes-Virus Proteases

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 140))

Abstract

Viruses within the herpes-virus family are identified based primarily on morphology, as all herpes viruses contain a linear double-stranded DNA genome within an icosadeltahedral capsid, surrounded by a tegument and enclosed within a viral envelope. The tegument is a region between the capsid and envelope that has no distinct features in electron micrographs (ROIZMAN and FURLONG 1974). These viruses have both a lytic phase of their life cycle, resulting in the generation of infectious virus that may cause disease in the susceptible host, and a latent phase characterized by limited gene expression, during which no infectious virus can be isolated. Latent virus can be reactivated in response to a variety of stimuli, which may again result in disease manifestations (ROIZMAN 1993).

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Authors and Affiliations

  1. Departments of Molecular Virology and Host Defense, Smith Kline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA, Mail Code UE0447,19406, USA

    C. E. Dabrowski

  2. Department of Structural Biology, Smith Kline Beecham Pharmaceuticals, 709 Swedeland Road, Mail Code UE0447,19406, King of Prussia, PA, USA

    X. Qiu & S. S. Abdel-Meguid

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  1. C. E. Dabrowski
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  2. X. Qiu
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  3. S. S. Abdel-Meguid
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Editors and Affiliations

  1. Max-von-Pettenkofer Institut für medizinische Mikrobiologie, LM Universität, LS Virologie Pettenkoferstr. 9a, D-80336, München, Germany

    Klaus von der Helm Ph.D., M.D.

  2. DuPont Pharmaceutical Co Research and Development, Edperimental Station, E336/31B, Wilmington, DE, 19880-0336, USA

    Bruce D. Korant Ph.D.

  3. Drug Discovery and Development, Source Precision Medicine, 2425 N. 55th Street, Suite 111, Boulder, CO, 80301, USA

    John C. Cheronis M.D., Ph.D. (Vice President) (Vice President)

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© 2000 Springer-Verlag Berlin Heidelberg

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Dabrowski, C.E., Qiu, X., Abdel-Meguid, S.S. (2000). The Human Herpes-Virus Proteases. In: von der Helm, K., Korant, B.D., Cheronis, J.C. (eds) Proteases as Targets for Therapy. Handbook of Experimental Pharmacology, vol 140. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57092-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-57092-6_6

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