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Voltage-Gated Calcium-Modulated Potassium Channels of Large Unitary Conductance: Structure, Diversity, and Pharmacology

  • Chapter
Pharmacology of Ionic Channel Function: Activators and Inhibitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 147))

Abstract

Calcium-sensitive and voltage-dependent channels of large unitary conductance (BKca) are found ubiquitously distributed in different cells and tissues where they participate in regulating many cellular processes (Latorre et al. 1989). Because cytosolic Ca2+activates BKcachannels they play an important role in coupling chemical to electrical signaling. In neurons they contribute to action potential repolarization (e.g., Sah 1996) and in presynaptic terminals they appear to modulate transmitter release (Robitaille et al. 1993; Knaus et al. 1996; Yazejian et al. 1997; but see Warbington et al. 1996). BKcachannels are present abundantly in virtually all types of smooth muscle cells and they are crucial in controlling smooth muscle tone (Anwer et al. 1993; Brayden and Nelson 1992; Nelson et al. 1995; for reviews see Nelson and Quayle 1995; Sanders 1992). These channels also control fluid secretion (Peterson 1986) and fluid reabsorption (Guggino et al. 1987). In chick cochleae different variants of the BKcachannel may help to determine the characteristic frequency of each hair cell helping to establish the tonotopic map (Dhasakumar et al. 1997; Rosenblatt et al. 1997; Ramanathan et al. 1999). BKcachannels were cloned fromDrosophilataking advantage of the existence of the mutant slowpoke (Slo)in which this potassium current is absent (Elkins et al. 1986; Gho and Mallard 1986). The primary sequence of theSlo protein showed that that BKcachannels

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Authors
  1. R. Latorre
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  2. C. Vergara
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  3. O. Alvarez
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  4. E. Stefani
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  5. L. Toro
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Editors and Affiliations

  1. Saitama Medical School, 38 Morohongo, Moroyama Iruma-Gun, Saitama, 350-0495, Japan

    Makato Endo M.D., Ph.D.

  2. Department of Pharmacology II Graduate School of Medicine and Faculty of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yoshihisa Kurachi

  3. Department of Molecular Neurobiology and Pharmacology School of Medicine, University of Tokyo, Hongo 7-3-1, Bukyo-ku, Tokyo, 113-0033, Japan

    Masayoshi Mishina

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Latorre, R., Vergara, C., Alvarez, O., Stefani, E., Toro, L. (2000). Voltage-Gated Calcium-Modulated Potassium Channels of Large Unitary Conductance: Structure, Diversity, and Pharmacology. In: Endo, M., Kurachi, Y., Mishina, M. (eds) Pharmacology of Ionic Channel Function: Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 147. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57083-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-57083-4_8

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